imatinib resistance
BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance
... for imatinib- resistance in these cell ...unlike imatinib, nilotinib is neither imported via hOCT-1, nor exported via ABCB1 ...that imatinib-resistance was caused by deregulated ...
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Two different point mutations in ABL gene ATP-binding domain conferring primary imatinib resistance in a chronic myeloid leukemia (CML) patient: A case report
... an imatinib-resistant CML ...partial imatinib resistance, ...primary imatinib resistance in same patient at the same ...primary imatinib resistance is one of the emerging ...
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Deciphering the mechanism of Indirubin and its derivatives in the inhibition of Imatinib resistance using a “drug target prediction gene microarray analysis protein network construction” strategy
... inhibit imatinib resistance, in- cluding indirubin, indirubin derivative E804, and indirubin-3-acetoxime ...inhibit imatinib resistance by 11 related ...
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RACK1 overexpression is linked to acquired imatinib resistance in gastrointestinal stromal tumor
... with imatinib, which inhibits KIT and PDGFR, controls advanced disease in about 80% of gastrointestinal stromal tumor (GIST) patients, resistance to imatinib often ...degradation. Imatinib ...
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Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies
... upon imatinib-resistance was evaluated treating R-KCL22 cells with imatinib or CX- 5011, ...of imatinib is required in imatinib-resistant CML cells to counteract the constitutive ...
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<p>Chloroquine Combined with Imatinib Overcomes Imatinib Resistance in Gastrointestinal Stromal Tumors by Inhibiting Autophagy via the MAPK/ERK Pathway</p>
... of Imatinib-Sensitive GIST882 and GIST882-ir (GIST 882 Imatinib-Resistant) Cells In this study, the drug concentration gradient method was used to establish the imatinib-resistant GIST (GIST882-ir ...
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Original Article Human umbilical cord mesenchymal stem cells restore imatinib and doxorubicin sensitivity in drug-resistant chronic myeloid leukemia cells
... that resistance of K562 cells is inde- pendent of BCR-ABL, but instead due to activa- tion of the FoxO3a-MDR1 ...in imatinib-resistant versus -sensitive K562 ...of imatinib-resistant K562 ...in ...
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PubMedCentral-PMC5433768.pdf
... drug resistance in several different human cancers, however mechanisms regulating BIRC6 have not been extensively ...an imatinib-resistant chronic myelogenous leukemia (CML) cell line (MYL-R) identified ...
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Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors
... with imatinib resistance. Imatinib did not inhibit this mutant at concentrations of up to 3000 nM, suggesting that there are marked differences in how the two inhibitors interact with ...with ...
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Targeted treatment of imatinib-resistant chronic myeloid leukemia: Focus on dasatinib
... of imatinib in chronic myeloid leukemia has been remarkable, but the development of resistance and the persistence of minimal residual disease have dampened the initial enthusiasm for this much heralded ...
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Inactivity of imatinib in gastrointestinal stromal tumors (GISTs) harboring a <em>KIT </em>activation-loop domain mutation (exon 17 mutation pN822K)
... genes. Imatinib mesylate is an oral small molecular tyrosine kinase inhibitor that mainly targets abl, c-KIT, and ...PDGFRα. Imatinib achieves disease control in approximately 70%–85% of patients with ...
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Proliferation inhibition and apoptosis induction of imatinib-resistant chronic myeloid leukemia cells via PPP2R5C down-regulation
... to imatinib in Bcr-Abl-overexpressing cells and cells expressing the imatinib-resistant Bcr-Abl kinase domain mutations H396P and Y253F ...in imatinib-sensitive and imatinib-resistant CML cell ...
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Original Article Inhibition effect of Peg-IFNα-2b and Imatinib alone or combination on imatinib-resistant gastrointestinal stromal tumors cell lines
... the Imatinib resistance that, if the disease progress, the patients of 400 mg/d dose group were distributed to the high dose group of 800 mg/d [5, ...mg/d Imatinib treatment group was rather ...drug ...
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<p>Durable Molecular Remission in a Lymphoid BP-CML Patient Harboring T315I Mutation Treated with Anti-CD19 CAR-T Therapy</p>
... T315I and P-loop mutations are associated with the high- est level of imatinib resistance and the worst clinical outcome. 21 – 26 Furthermore, recent studies have shown that about half of the non-responsive ...
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DNA Methylation and Its Role in the Development of Leukemia
... with Imatinib and this suggests relevance between epigenetic silencing and resistance ...for Imatinib resistance ...inducing Imatinib resistance in CML patients ...
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Massive Intra-Abdominal Imatinib-Resistant Gastrointestinal Stromal Tumor in a 21-Year-Old Male
... confer imatinib sensitivity ...with imatinib resistance, was also identified ...in imatinib- resistant GISTs ...with imatinib and sunitinib refractory GIST ...
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Dasatinib for the treatment of chronic myeloid leukemia: patient selection and special considerations
... in imatinib resistance and/or intolerance, as well as in the frontline setting in patients with chronic myeloid leukemia-chronic phase, and also in patients with advanced ...
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Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy
... to imatinib, dasatinib enables patients with chronic phase CML to achieve faster and deeper treatment responses ...the imatinib arm, and BCR-ABL transcript ...of imatinib is instead replaced by a ...
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The pharmacogenetics of imatinib
... BCRP, which, like P-gp, causes removal of IM, is encoded by the ABCG2 gene located on chromosome 4q22. BCRP is expressed not only in hematopoietic stem cells but also in hepatic and intestinal epithelial cells, and this ...
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Applying the discovery of the Philadelphia chromosome
... of imatinib mesylate, a clinically successful inhibitor of the BCR-ABL ...that imatinib-resistant kinase domain muta- tions are the major cause of relapse during imatinib therapy and the subsequent ...
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