Immediate Early 2 Gene
An inducible promoter mediates abundant expression from the immediate-early 2 gene region of human cytomegalovirus at late times after infection.
... 11 An Inducible Promoter Mediates Abundant Expression from the Immediate-Early 2 Gene Region of Human Cytomegalovirus at Late Times after Infection ELKE PUCHTLER AND THOMAS STAMMINGER* I[r] ...
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Human Cytomegalovirus Immediate-Early 2 Gene Expression Blocks Virus-Induced Beta Interferon Production
... A number of viral proteins have been shown to disrupt these activation pathways and block enhanceosome formation. The Ebola virus VP35 protein and the hepatitis C virus NS3/4A protease interfere with the phosphorylation ...
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Discordant expression of the immediate-early 1 and 2 gene regions of human cytomegalovirus at early times after infection involves posttranscriptional processing events.
... 2273 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Expression of the immediate-early 1 and 2 IE-1 and IE-2 gene region of human cytomegalovirus HCMV studied during in[r] ...
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Comparison of the Complete DNA Sequences of the Oka Varicella Vaccine and Its Parental Virus
... in gene 62, located within the IRS region (or in gene 71 located within the TRS region) and its flanking regions, although no mutations were found in genes encoding other transactivators, such as genes 4, ...
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Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins.
... The cellular protein-IE2 interactions, including two distinct protein complexes and several individual proteins, were mapped to specific functional domains of IE2 known to be required fo[r] ...
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The PK Domain of the Large Subunit of Herpes Simplex Virus Type 2 Ribonucleotide Reductase (ICP10) Is Required for Immediate-Early Gene Expression and Virus Growth
... genes, early genes involved in viral DNA syn- thesis must be turned on by the reactivating stimuli resulting in limited DNA ...IE gene expression, leading to the lytic cascade and the production of ...
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Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes.
... human T cells do not produce virus particles. We report the lack of virion production even after chemical treatment. In contrast, chemical reactivation occurs readily in Epstein-Barr virus-transformed human B cells (67). ...
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Genome-Wide Histone Acetylation Profiling of Herpesvirus saimiri in Human T Cells upon Induction with a Histone Deacetylase Inhibitor
... a gene with strong homology to the family of dihydrofolate re- ductases (orf2); however, its transcription seems unaffected by histone acetylation, since expression of this gene cannot be detected ...as ...
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Murine Cytomegalovirus m142 and m143 Are both Required To Block Protein Kinase R-Mediated Shutdown of Protein Synthesis
... viral immediate-early and early proteins were expressed, but viral DNA replication and synthesis of the late-gene product glycoprotein B were inhibited, even though mRNAs of late genes were ...
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Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter.
... Although there are protein products of various sizes associated with IE2 and these gene products are detected in infected cells at early times after infection, we were able to demonstrat[r] ...
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Structure and expression of murine cytomegalovirus immediate-early gene 2.
... Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region.. Promoter-specific trans activation and repression by human cytomegal[r] ...
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Cytomegalovirus immediate early genes prevent the inhibitory effect of cyclosporin A on interleukin 2 gene transcription
... transcription. This effect was noted regardless of the time of CsA addition relative to the time of stimulation and was independent of CsA concentration. CsA had no effect on the CMV or the IL-2 receptor ...
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The Human Cytomegalovirus Major Immediate-Early Distal Enhancer Region Is Required for Efficient Viral Replication and Immediate-Early Gene Expression
... LS gene expression during viral latency is unknown, although deletion of this region en bloc would likely disrupt the transcriptional initiation of LS ...MIE gene expression and viral replication, we con- ...
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SRF activation in immediate early gene transcription
... reporter gene has been used as a readout for SRF activation, since it comprises the c-fos transcription unit controlled by a chimaeric promoter containing cytoskeletal actin TATA region (minimal promoter) and ...
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trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus.
... To examine other promoter targets in transient CAT assays, plasmids containing HCMV HindIIIC pRL103 or SCMV HindIII-H pTJ148, which include the intact major IE gene coding regions IE1 pl[r] ...
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Novel regulatory properties of the IE1 and IE0 transactivators encoded by the baculovirus Autographa californica multicapsid nuclear polyhedrosis virus.
... The results of this study in conjunction with previous results suggest that the IEl gene encodes a multifunctional gene product that may be involved in i repression of immediate-early ge[r] ...
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Enhancerless Cytomegalovirus Is Capable of Establishing a Low-Level Maintenance Infection in Severely Immunodeficient Host Tissues but Fails in Exponential Growth
... tive immunity, are not completely devoid of innate immunity, which might have led to an early resolution of a low-level infection by the enhancerless virus. However, it still remains to be determined whether the ...
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Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities
... During embryonic development, CCN1 is widely expressed in the cardiovascular system [9]. Prominent cardiac expression of CCN1 was seen as early as E8.5 in mice expressing lacZ under the control of the endogen- ous ...
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Sequence and structural organization of murine cytomegalovirus immediate-early gene 1.
... In this paper we present the physical organization, as well as the deduced amino acid sequence and secondary structure, of pp89 and the complete nucleotide sequence of iel.. The relation[r] ...
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Cellular RNA Helicase DHX9 Interacts with the Essential Epstein-Barr Virus (EBV) Protein SM and Restricts EBV Lytic Replication
... DHX9, a DExH box helicase family member, participates in nearly every cellular pathway involving RNA, including transcription, processing, transport, and translation (18). The general functional domains of DExH box ...
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