immune cell
Immune cell trafficking from the brain maintains CNS immune tolerance
... T cell receptor transgenic 2D2 C57BL/6 mice respond to MOG, they display a low rate of spontaneous CNS-wide ...Breaking immune tolerance in 2D2 mice (with pertus- sis toxin treatment alone) significantly ...
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Drosophila immune cell migration and adhesion during embryonic development and larval immune responses
... its immune system serves as an excellent system to study how cellular migration occurs within diverse in vivo ...Drosophila immune system likely repre- sent ancient programs upon which evolution has elabo- ...
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Immune cell therapy for hepatocellular carcinoma
... T cell therapy Many studies to date have described side effects associated with gene-modified T cell ...CAR-T cell therapy, cytokine release syndrome (CRS) involving IFN-γ and interleukin-6 (IL-6) ...
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Immune cell subset differentiation and tissue inflammation
... IFN-γ inhibits Th2 proliferation by interfering with Th2 costimulator, IL-1 [203]. IL-2 signaling via STAT5 con- strains Th17 cell generation [204], while IL-6 inhibits TGF-β-induced Treg differentiation [205]. ...
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Endothelial cells and immune cell migration
... 14. Borges E, Tietz W, Steegmaier M, Moll T, Hallmann R, Hamann A, Vestweber D: P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and sup- ports migration into ...
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Novel immune cell-based therapies for atherosclerosis
... 10 µm cryosections of the liver were stained with Oil-Red-O and hematoxylin to determine lipid content. To determine aortic root plaque size, 10 µm cryosections were stained with Oil-Red-O and haematoxylin (Sigma ...
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Innate Immune Cell Regulation of Metabolic Homeostasis
... Figure 4. Obese white adipose tissue (WAT) is characterized by type 1 cytokine- associated immune responses. In obese WAT, adipocyte hypertrophy is associated with hypoxia and adipocyte cell death. Dead and ...
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Immune cells: more than simple carriers for systemic delivery of oncolytic viruses
... modified immune cells could express oncolytic viral vectors which could then be activated when cells were activated at tumor ...infect immune cells with OVs and adoptively transfer them into tumor-bearing ...
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Deletion of the K1L Gene Results in a Vaccinia Virus That Is Less Pathogenic Due to Muted Innate Immune Responses, yet Still Elicits Protective Immunity
... ⫺ cell numbers were higher in vΔK1L- versus PBS-inoculated ears, suggest- ing that vΔK1L infection elicited moderate infiltration of ...reduced immune cell infiltrates, implying that infiltrating ...
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Dok-3 deficient mice display different immune clustering and Tim-3 expression
... T-cell immunoglobulin and mucin-domain-contain- ing molecule 3 (Tim-3) are a membrane protein initially identified as a negative regulator of Th1 immunity [9, 10]. A strong correlation between Tim-3 expression and ...
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Molecular profile of cochlear immunity in the resident cells of the organ of Corti
... of cell populations, sensory cells and supporting ...of immune genes in supporting cells ...sensory cell debris ...mediate immune signaling between sensory cells in the organ of Corti and the ...
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Immunoregulatory properties of clinical grade mesenchymal stromal cells: evidence, uncertainties, and clinical application
... on immune cell-related parameters, a precise description of the most important variables is also required, including strict qualification of effector immune cells, use of various MSC to immune ...
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Immune response to C. novyi-NT immunotherapy
... the immune response to CNV‑NT spores to better understand which immune pathways might play a role in the response to this bacteriolytic ...NK cell‑ like function after ...NK cell‑like function ...
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Pathobiology of the 129:Stat1 −/− mouse model of human age related ER positive breast cancer with an immune infiltrate excluded phenotype
... modified mouse (GMM) models of human breast cancer [1]. In contrast to most other mouse models of human breast cancer, the resulting tumors are ovary-dependent and have uniformly high levels of estrogen receptor (ER)-α ...
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Melanoma NOS1 expression promotes dysfunctional IFN signaling
... strongest immune sup- pressive activity also displayed a distinct phenotype both at the functional (decreased IFN-α-p-STAT1, Figure 1C) and transcrip- tional levels (Figure 2); (c) the idiosyncratic behavior could ...
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Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells
... that immune cells in co-cul- tures pretreated with ...PP immune cell subsets in the response to poly (I:C) stimulation in order to obtain a more complete panorama of the mucosal immune ...
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Immunohistochemical phenotyping of T cells, granulocytes, and phagocytes in the muscle of cancer patients: association with radiologically defined muscle mass and gene expression
... of immune cells participating in innate and adaptive responses has been observed in several tissues and organs ...the immune environment of the skeletal muscle influencing muscle mass ...blood immune ...
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Prognostic impact of immune gene expression signature and tumor infiltrating immune cells in localized clear cell renal cell carcinoma
... intra-tumoral immune cell infiltrates (lymphocytes, plasma cells, macro- phages, neutrophils) on recurrence in patients with local- ized renal cell carcinoma (RCC) have produced conflicting ...
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Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
... different immune cell infiltrations were additionally analyzed using univariate and multivari- ate cox regression including MSI status, hypermutation, methylation subtype, and tumor site (left and right ...
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Hypoxia inducible factors: a central link between inflammation and cancer
... infiltrating immune cells function in the hypoxic tumor environment. Immune cell expres- sion of HIF-1α and HIF-2α regulates effector function (Table 1) ...matory cell functions in addition to ...
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