Immune complex mediated disease
Cancer as an immune-mediated disease
... the immune system affects cancer development and progression is one of the most challeng- ing questions in ...the immune system can recognize and respond to neoplastic cells was first proposed in the 19th ...
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Integrative statistical methods for the genomic analysis of immune-mediated disease
... 5.1.3 The importance of orthogonal functional evidence Undoubtedly, whilst the use of PCHi-C data in this thesis is novel there are multiple technical and biological reasons why it is no panacea for the elucidation of ...
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Genetic and Acquired Abnormalities in C3 Glomerulopathy and Primary Immune Complex-Mediated MPGN
... The disease is considered moderate when proteinuria is greater than 500mg/24h despite supportive therapy, or the biopsy has a moderate inflammation or there is a disease progression defined by recent serum ...
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Original Article Complement membrane attack complex is related with immune-mediated necrotizing myopathy
... C5b-9 has been associated with kidney dis- ease, nervous system disease, blood disease, atherosclerosis and pregnancy hypertension disease. C5b-9 is obviously expressed in glo- merular endothelial ...
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C4 nephritic factor in patients with immune-complex-mediated membranoproliferative glomerulonephritis and C3-glomerulopathy
... specific immune response may reflect ongoing epitope spreading driven by persisting complement coated ...are disease mod- ifiers or even epiphenomenon of the disease progress in C3G, the question ...
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Role of exosomes in the regulation of T-cell mediated immune responses and in autoimmune disease
... lipid composition as natural exosomes, to which recombinant TRAIL was fixed on their surface by using a Ni +2 -bound coordination complex, termed LUV-TRAIL. These TRAIL- coated liposomes were then successfully ...
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Host defense molecule polymorphisms influence the risk for immune mediated complications in chronic granulomatous disease
... These results suggest that genotype analysis of cohorts with a restriction or ablation of a central component in a host defense pathway makes possible the identification of gene/function rela- tionships in other ...
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Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus
... nef is one of six auxiliary genes found in simian immunode- ficiency virus (SIV) and human immunodeficiency virus (HIV). Unlike the gag, pol, and env genes, nef is not essential for the ability of virus to replicate. ...
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Urokinase type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement
... involving immune complex formation and deposition - namely, the CIA, CAIA and K/BxN serum transfer models - as opposed to the monoarticular mod- els - AIA and ...other immune ...
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Borna Disease Virus Nucleoprotein (p40) Is a Major Target for CD8+-T-Cell-Mediated Immune Response
... Borna disease virus (BDV) and natural BDV infection of horses and sheep leads to a virus-induced T-cell-mediated immunopathology in the central nervous ...histocompatibility complex class ...
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Repurposing Miltefosine for the Treatment of Immune-Mediated Disease?
... Introduction Miltefosine, or hexadecylphosphocholine, was developed in the early 1980s as a potential cytostatic drug. Miltefosine largely failed development for oncology and is now best known as an oral treatment of ...
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Immunosuppressive Therapy in the Treatment of Immune-mediated Disease
... Because the T-helper cell antigen plays an important role in the generation and amplification of the immune response, monoclonal antibodies directed against this antigen might [r] ...
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Immune complex–mediated antigen presentation induces tumor immunity
... containing immune complexes. Tumor protection was eliminated when immune complex–loaded DCs lacked β 2 microglobulin, TAP, or MHC class II, demonstrating that Fc receptor–targeted anti- genic uptake ...
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Immune Mediated Hemolytic Anemia: Can we beat this disease?
... Complications of IMHA IMHA patients are in a pro-inflammatory state, predisposing them to numerous complications, including thromboembolic disease and pancreatitis. Prolonged, severe anemia can lead to tissue ...
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Elaboration of toxic oxygen by products by neutrophils in a model of immune complex disease
... J Clin Invest. 1976;57(4):836-841. https://doi.org/10.1172/JCI108359. Contact between human neutrophils and aggregated immunoglobulin G bound to micropore filters has been studied as a model of the pathogenesis of tissue ...
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CD55 deposited on synovial collagen fibers protects from immune complex mediated arthritis
... The hybridization signal of CD55 in the synovial sublin- ing was weaker, yet detectable, which fits its wide cellu- lar distribution, including most immune cells [21]. FLS, obtained from synovial tissue by ...
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Antibody Mediated Immune Response and Cellular Mediated Immune Response Characterization in Brahman Cattle
... There is also evidence to support that allergy sensitivity and innate immunity can be developed and influenced during pregnancy, as children born to mothers that were very active in farming were less likely to develop ...
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Immune-Mediated Hemolytic Anemia
... quela is an increased risk of infection by encapsulated organisms, namely Haemophilus influenzae, Neisseria meningitides and N gonorrhoea. In the case of N men- ingitides, although the deficient individuals have an ...
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Immune mediated thrombocytopenia of malaria
... Immune-mediated thrombocytopenia of malaria. J G Kelton, … , J Gauldie, J Jensen J Clin Invest. 1983;71(4):832-836. https://doi.org/10.1172/JCI110836. Thrombocytopenia frequently complicates malarial ...
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Relationship of antibody affinity to onset of immune complex disease in New Zealand mice
... Studies of other strains have shown that 'high affinity strains' (A, C3H) make antibody of high affinity to all antigens tested (HST, DNA, human and bovine serum albumin, dinitrophenol- [r] ...