Immune surveillance
Sindbis Virus Can Exploit a Host Antiviral Protein To Evade Immune Surveillance
... evade immune detection (46). ZAP-mediated evasion of the immune surveillance by SVNI is conceptually similar to but mechanistically different from these reported ...
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Original Article Differential distribution of immune cells in breast invasive carcinoma vs. breast carcinoma in situ and its significance in interpretation of immune surveillance
... Abstract: Immune surveillance is a highly controversial subject in both the field of immunology and cancer ...exert immune response to tumors. On the other hand, it is believed that immune ...
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Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance
... Several retrospective and population-based studies and meta-analysis demonstrated that patients with MMR- deficient CRC have a more favourable stage-adjusted prognosis compared with patients whose tumours have intact MMR ...
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Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence.
... The recurrence competent phenotype is also associated with an acquisition of an insensitivity to innate immune effectors (44). Therefore, we next investigated whether NK cells, a major effector of innate ...
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Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle
... an immune response within the ...of immune- mediated CNS pathologies including chronic inflamma- tory diseases such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis ...
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The multifaceted role of autophagy in tumor evasion from immune surveillance
... evade immune system by disabling components of the immune system that have been dispatched to eliminate them and or by activating multiple overlapping mechanisms to escape fully functional immune ...
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Lung tumor NF κB signaling promotes T cell–mediated immune surveillance
... In addition to inflammation, NF-κB also exerts protumor effects through cancer cell–intrinsic regulation of cell survival and tumor growth (22, 23, 40). Mouse studies have shown that NF-κB is important for development ...
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M cell-dependent antigen uptake on follicle-associated epithelium for mucosal immune surveillance
... mucosal immune surveillance by actively transporting external antigens from the gut lumen to the lymphoid ...mucosal immune responses represented by the induction of secretory immunoglobulin A ...
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Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53
... In view of the important role of BAG6 together with CBP/p300/p53 in tumor immune surveillance, an impaired function of BAG6 and CBP/p300 might be expected, as generally observed for p53. However, mutations ...
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Genetic instability as a driver for immune surveillance
... capture immune editing, a phe- nomenom at the core of immunotherapy failure, in which the tumor might develope immune resistance by means of either buffering the growth of immunosilent cells or edit- ing ...
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CD80 and CD86 Control Antiviral CD8+ T-Cell Function and Immune Surveillance of Murine Gammaherpesvirus 68
... nological surveillance of MHV-68 in the CD28 ⫺/⫺ and CD80/ CD86 ⫺/⫺ ...of immune surveillance ob- served in CD80/86 ⫺/⫺ mice is independent of CD28, and we also showed it is independent of CTLA-4, ...
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Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice
... the immune surveillance of tumor antigens because they produce an extracellular matrix that cannot support interstitial DC migration or because their proliferation sufficiently deranges tissue architec- ...
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Enhanced tumor immune surveillance through neutrophil reprogramming due to Tollip deficiency
... innate immune checkpoint molecules such as PD-L1 in suppressing T cell function and promoting tumor immune evasion ...diverse immune environments (30, 31), which clearly can not be fully addressed ...
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Murine Cytomegalovirus m02 Gene Family Protects against Natural Killer Cell-Mediated Immune Surveillance
... eral of the cell types missing in this mouse strain normally controls the growth of SMsubm02–16. In other words, one or more members of the m02 gene family apparently antagonize host immune functions to facilitate ...
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Evasion of Immune Surveillance in Low Oxygen Environments Enhances Candida albicans Virulence
... IMPORTANCE Successful human colonizers have evolved mechanisms to bypass im- mune surveillance. Infiltration of PMNs to the site of infection led to the generation of a low oxygen niche. Exposure to low oxygen ...
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Immune surveillance of tumors
... the immune system to identify and destroy nascent tumors, and to thereby function as a primary defense against cancer, has been debated for many ...particular immune cell types, effector molecules, and ...
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Renal immune surveillance and dipeptidase 1 contribute to contrast induced acute kidney injury
... of immune surveil- lance whereby monocytes/macrophages recruited to the kidney ingest contrast transported from the urine through direct interac- tion with tubular ...
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Initiation and Regulation of CNS Autoimmunity: Balancing Immune Surveillance and Inflammation in the CNS
... other ideas of disease initiation. For example, primary autoimmunity is that it allows for the initial adaptive ral/bacterial infection) or self-antigens (e.g., from minor trauma), and therefore connects the standard ...
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NK cell heparanase controls tumor invasion and immune surveillance
... Even though we have shown that a function of heparanase in NK cells is to break down the ECM, the role of heparanase extends beyond tissue invasion in other immune cell subsets. For example, pro-heparanase can ...
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Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 Are Stimulated within the Eye during Experimental Murine Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression
... evade immune surveillance or protect host cells remains to be seen, but it is clear from the present investigation that intraocular MCMV infection of mice with MAIDS results in massive stimulation of ...
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