Immunoglobulin A nephropathy
Paraneoplastic immunoglobulin A nephropathy and associated focal segmental glomerulosclerosis in asymptomatic low volume B-cell lymphoma – a case report
... Case presentation: A 53 year old gentleman presented with nephrotic range proteinuria (urine protein creatinine ratio of 662 mg/mmol) on a background of type 2 diabetes mellitus (glycosylated haemoglobin: < 6%), ...
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Original Article Identification of mannose-binding lectin as a mechanism in progressive immunoglobulin A nephropathy
... A nephropathy (IgAN), first described by Heberden in 1801 was the most common glomerulonephritis all over the world and characterized by IgA antibody that depos- ited in the glomerulus ...
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The association of tumor necrosis factor superfamily 13 with recurrence of immunoglobulin A nephropathy in living related kidney transplantation
... Background: An increasing amount of evidence has demonstrated an association between an increase in the level of tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) ...
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Long Term Outcome of Renal Allografts in Patients with Immunoglobulin A Nephropathy
... recipients. Immunoglobulin A nephropathy (IgAN) is a leading cause of end-stage renal disease (ESRD) worldwide and its recurrence has been reported in ...
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Spot urine protein/creatinine ratio as a reliable estimate of 24-hour proteinuria in patients with immunoglobulin A nephropathy, but not membranous nephropathy
... Background: Proteinuria is known to be associated with both kidney function deterioration and cardiovascular diseases. While proteinuria estimation from 24-h urine samples has traditionally been considered as the ...
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Gene alterations in monocytes are pathogenic factors for immunoglobulin a nephropathy by bioinformatics analysis of microarray data
... Galactose-deficient immunoglobulin A1; GEO: Gene Expression Omnibus; HBDs: Healthy blood donors; HDAC10 : Histone deacetylase 10; IDs: Identification numbers; IgAN: Immunoglobulin A nephropathy; ...
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Increased C4 and decreased C3 levels are associated with a poor prognosis in patients with immunoglobulin A nephropathy: a retrospective study
... IgAN: Immunoglobulin A nephropathy; IQR: Interquartile range; M: Mesangium hypercellularity; MAP: Mean arterial pressure; MBL: Mannose-binding lectin; S: Segmental glomerulosclerosis; SD: Standard ...
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Original Article Association of ACE, AGT, eNOS gene single nucleotide polymorphism with Immunoglobulin A nephropathy in Xinjiang Uygur
... Abstract: The aim of the present study was to explore the correlation between single nucleotide polymorphisms ACE I/D (angiotensin-converting enzyme), AGT M235T (angioten-sinogen), eNOS G894T (endothelial nitricoxide ...
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Humoral immune response to influenza vaccination in patients with primary immunoglobulin A nephropathy An analysis of isotype distribution and size of the influenza specific antibodies
... IgA nephropathy (IgAN) is characterized by mesangial deposits of IgA1, increased serum IgA1 levels, and circulating immune complexes containing predominantly ...
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Role of genetic polymorphisms in factor H and MBL genes in Tunisian patients with immunoglobulin A nephropathy
... Abstract: The molecular mechanisms of IgA nephropathy (IgAN) remain poorly understood. Several different polymorphic genes have been investigated in order to demonstrate their pos- sible association with this ...
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A novel differential diagnostic model based on multiple biological parameters for immunoglobulin A nephropathy
... When serum IgA was combined with the other 2 para- meters, particularly manifestation and fibrinogen, the diagnostic accuracy of serum IgA increased from 75.6 to 83.9%, as determined by ROC curve analysis, suggesting ...
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Efficacy of tonsillectomy for the treatment of immunoglobulin A nephropathy recurrence after kidney transplantation
... Immunosuppressive therapy might not successfully prevent from IgAN recurrence even in this era after kidney transplantation [23]; there- fore, we evaluated the efficacy of tonsillectomy [r] ...
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Diagnosis and activity assessment of immunoglobulin A nephropathy: current perspectives on noninvasive testing with aberrantly glycosylated immunoglobulin A-related biomarkers
... To determine whether GdIgA1 is the sole effector mol- ecule of IgAN, Gharavi et al noted increased serum helix aspersa agglutinin-reactive GdIgA1 levels in patients with IgAN compared with those in their relatives; ...
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Anti Proteinuric Effect of Sulodexide in Immunoglobulin A Nephropathy
... IgA nephropathy pa- ...diabetic nephropathy patients, we found that long-term treatment with a high dose of sulodexide might re- duce urinary protein excretion in IgA nephropathy ...
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Clinical validation of immunoglobulin A nephropathy diagnosis in Swedish biopsy registers
... based on school urinary dipstick screening programs show a less marked male predominance. Since IgAN is often asymp- tomatic and spontaneous recovery sometimes occurs, this might be an indication that female IgAN ...
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Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus
... IgA nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus, renal biopsies from patients with these disorders were stained by immunofluorescence with monoclonal anti- IgA subclass reagents, ...
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Mesangial cell autoantigens in immunoglobulin A nephropathy and Henoch Schönlein purpura
... IgA nephropathy and Henoch-Schönlein purpura ...IgA nephropathy and HSP, autoimmunity was intermittently present, with fluctuating levels of IgG-MESCA detectable in ...IgA nephropathy, but ...
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Immunoglobulin A nephropathy Quantitative immunohistomorphometry of the tonsillar plasma cells evidences an inversion of the immunoglobulin A versus immunoglobulin G secreting cell balance
... Primary IgA nephropathy (Berger's disease) is characterized by renal deposits of IgA, the origin of which is still unknown. However, several clinical and biological findings suggest that these immunoglobulins ...
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Renal outcomes of STOP-IgAN trial patients in relation to baseline histology (MEST-C scores)
... eGFR: Estimated glomerular filtration rate; ESRD: End-stage renal disease; IgAN: Immunoglobulin A nephropathy; IMM arm: Patients under additional immunosuppression on top of optimized su[r] ...
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In Situ Hybridization Detection of Human Herpesvirus 6 in Brain Tissue From Fatal Encephalitis
... HHV-6, human herpesvirus 6; ISH, in situ hybridization; CSF, cerebrospinal fluid; IgG, immunoglobulin G; IgA, immunoglobulin A; IgM, immunoglobulin M; PCR, polymer- ase chain reaction; H[r] ...
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