immunological synapse
The immunological synapse
... Upon immunological synapse formation, CD28–CD80 interactions are facilitated and focused in the central region of the immunological synapse, very close to the site of TCR ...
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Membrane domains and the immunological synapse: keeping T cells resting and ready
... The idea that receptor or raft rearrangement will be important for signaling suggests that regulating this process will ultimately affect the immune response, as has been suggested to explain suppression of immune ...
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Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems
... In both NK and iNKT cells, both the Golgi complex and the endocytic recycling compartment, defined as HRP-positive structures with tubular morphologies (see, for example, Figures 2e and 2f), also polarise with the ...
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Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
... defective immunological synapse formation with APCs. Although this synapse dysfunction was in part a result of the CLL cells having poor APC function, defective actin polymerization was also ...
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Role of cytoskeletal remodeling in T cell receptor signaling and integrin activation at the immunological synapse
... The efficiency of an immune response critically depends on the ability of T cells to respond to antigens. Upon encountering cognate antigenic peptides on the surface of antigen-presenting cells, T cells form a ...
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Imbalance of immunological synapse-kinapse states reflects tumor escape to immunity in glioblastoma
... Activation of T cells requires physical contact with antigen-presenting cells (APCs) through the formation of the immunological synapse (IS) (5). After antigen recognition by CD3/T cell receptor (TCR) ...
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HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation
... cell immunological synapse, HIV Env may act as a costimulator that heightens the TCR activation of CD4 T cells and imparts to the cells the capacity to support higher levels of virus ...
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Engagement of the CD4 Receptor Affects the Redistribution of Lck to the Immunological Synapse in Primary T Cells: Implications for T-Cell Activation during Human Immunodeficiency Virus Type 1 Infection
... Understanding the molecular mechanisms underlying dysregulated immune responses in human immuno- deficiency virus type 1 (HIV-1) infection is crucial for the control of HIV/AIDS. Despite the postulate that HIV envelope ...
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Differential segregation in a cell cell contact interface: the dynamics of the immunological synapse
... neurological synapse has been the paradigm for cell-cell signaling for many years; a static long-term synapse mediating translocation of chemical signals across the ...
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The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV 1 from most other primate lentiviruses
... Viruses that infect T cells, including those of the lentivirus genus, such as HIV-1, modulate the responsiveness of infected T cells to stimulation by interacting APCs in a manner that renders the T cells more permissive ...
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Opposing Actin Networks Modulate the Mechano-Activation of the Integrin LFA-1 During Immunological Synapse formation
... stable synapse are all likely to be using similar regulation of the F-actin ...symmetric synapse is very analogous to that of migrating cells, with robust F-actin polymerization at the leading edge and ...
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IRAK 4: a new drug target in inflammation, sepsis and autoimmunity
... proximal signals (15, 16). These studies have been confirmed and extended by the work of Egen and Allison who demonstrate that CTLA-4 is at first localized in the uropod of activated T cells, where the microtubule ...
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Inhibition of T-Cell Receptor-Induced Actin Remodeling and Relocalization of Lck Are Evolutionarily Conserved Activities of Lentiviral Nef Proteins
... the immunological synapse (IS) such as relocalization of the Lck kinase, as well as early inhibition of TCR/CD3 complex (TCR-CD3)-mediated actin rearrangements and tyrosine ...
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Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity
... Anti- gen specific T cells interact with dendritic cells (DC) within intact explanted lymph nodes (LN), and it has been observed that immunological synapse formation and prolonged intera[r] ...
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HIV-1 Nef: a multifaceted modulator of T cell receptor signaling
... as immunological synapse (IS) and trigger a broad range of downstream signaling events including sequential tyrosine phosphorylation cascades, rapid ele- vation of intracellular calcium flux and dynamic ...
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Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases
... an immunological synapse (IS), and specific identification of complex by T cells including two activating signals are necessary steps that lead to T cell ...
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A hybrid CMOS-memristor neuromorphic synapse
... memristive synapse, the triplet STDP behaviour of the suppressive STDP model can be ...developed synapse in reproducing other synaptic plasticity experimental data, such as quadruplet and pairing frequency ...
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Evolution of complexity in the zebrafish synapse proteome.
... known as the teleost-specific genome duplication (TSGD). Although the TSGD increased the number of protein-coding genes in zebrafish 14 and other fish compared to mammals, it is unknown whether this influenced synapse ...
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Evolution of complexity in the zebrafish synapse proteome
... whether synapse genes were more likely to be retained after the TSGD than genes expressed elsewhere in the brain or in other ...that synapse genes have been retained at higher frequencies after the TSGD ...
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Original Article Prevalence of programmed death-1 ligand-1 (PD-L1) and infiltrating lymphocytes in human gastric carcinogenesis
... activated immunological status was indicated to switch to an immunological suppressive status in intestinal metaplasia/atrophic gastritis tissue and gastric ...
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