Improved bioavailability
Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D
... Extensive survey of literature and patent databases did not reveal any cyclovirobuxine-D-loaded SNEDDS designed for improvement of oral absorption. The current study discusses the optimization of SNEDDS for ...
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SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM OF CANDESARTAN CILEXETIL WITH IMPROVED BIOAVAILABILITY
... Droplet size determines the rate and extent of drug release as well as drug absorption. Smaller the particle size, larger the interfacial surface area which may lead to more rapid absorption and improved ...
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Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation
... Results: Niosomes showed entrapment efficiency .80%, particle size ,550 nm, and zeta potential ranging from -16.8±0.13 to -29.7±0.15. The produced vesicles showed significantly higher amounts of drug permeated across ...
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PHYTOSOME: A NOVEL DRUG DELIVERY SYSTEM IN THE MIDDLE OF IMPROVED BIOAVAILABILITY
... Most of the phytosomal studies are focused to Si- lybum marianum which contains premier liver- protectant flavonoids. The fruit of the milk thistle plant (S. marianum, Family Steraceae) contains fla- vonoids known for ...
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Original Article Danshen-phospholipid complex for improved bioavailability: preparation, in vitro and in vivo evaluations
... oral bioavailability was increased by 97% and the complex exhibited sustained release ...oral bioavailability was nearly 4 times higher than that of ...oral bioavailability of the main medicinal ...
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Improved Bioavailability of Rifampicin Nanoparticles from Fixed Dose Combination with Isoniazid, Pyrazinamide and Ethambutol.
... 5 resulted in a reduced dosing frequency in a murine TB model. The administration routes of PLGA nano / micro particle may vary from parenteral, oral, dermatological, pulmonary and nasal to ocular.Recently, diclofenac ...
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Optimization of caseinate-coated simvastatin-zein nanoparticles: improved bioavailability and modified release characteristics
... significantly improved the pharma- cokinetic profile and bioavailability of SMV by more than fourfold in comparison with SMV oral ...be improved for longer time and with lower dosing frequency, which ...
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Formulation development and optimization of fast dissolving film containing carvedilol nanocrystals for improved bioavailability
... In this work, fast dissolving films (FDF) were prepared using nanocrystal formulations in order to optimise dissolution properties of lipophilic, poorly soluble drug Cavedilol. Drug nanocrystals are crystals with a size ...
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Preparation, characterization and relative bioavailability of oral elemene o/w microemulsion
... and improved bioavailability can be prepared successfully using elemene as the oil phase and drug, polysorbate 80 as the surfactant along with ethanol, propylene glycol, glycerol as the cosurfactants, and ...
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Silica-coated flexible liposomes as a nanohybrid delivery system for enhanced oral bioavailability of curcumin
... and bioavailability of ...The bioavailability of CUR-SLs and CUR-FLs was ...markedly improved the stability of flexible liposomes, and CUR-SLs exhibited a ...in bioavailability compared with ...
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Hot melt extrusion technique and its pharmaceutical applications: A review
... Significance of hot-melt extrusion techniques for pharmaceutical applications is growing rapidly over the last three decades. Industrial malleability has allowed hot-melt extrusion (HME) to gain wide acceptance and has ...
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Polymorph And Salts Of Active Pharmaceutical Ingredients
... salt: improved bioavailability, reduced inter- patient variability, improved overall therapeutic efficacy, good mechanical, polymorphic and/or chemical stability, excellent flow properties, good ...
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Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends
... low bioavailability, gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux ...to improved bioavailability and ...oral bioavailability, prevent first- pass metabolism ...
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Investigation of Different Formulation Approaches to Enhance Oral Bioavailability of Paromomycin
... oral bioavailability through formulation development for increased patient compliance and ...oral bioavailability were carried ...demonstrated improved oral bioavailability of paromomycin in ...
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Microparticulate hot melt pallets technology: a review
... Recent advances in novel drug delivery (NDDS) aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. Depending ...
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Optimized zein nanospheres for improved oral bioavailability of atorvastatin
... X-ray diffraction analysis was also performed to inspect the physical state of ATR in the developed formula after the formulation process. The raw ATR showed intense crystal- line peaks between 5 ° and 45 ° C. Zein ...
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<p>Co-crystals as a new approach to multimodal analgesia and the treatment of pain</p>
... cantly improved dissolution rate compared with aprepitant, has also been ...to improved bioavailability – may permit administration of lower doses of the API therein, API – coformer co-crystals do ...
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DEVELOPMENT AND IN VIVO EVALUATION OF NELFINAVIR EXTENDED RELEASE TRILAYER MATRIX TABLETS IN THE MANAGEMENT OF AIDS
... vivo bioavailability studies the extended release of Nelfinavir from trilayer matrix tablets also provides for higher plasma drug content and improved ...
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Lyophilized Ethinylestradiol Nanosuspension: Fabrication, Characterization and Evaluation of in vitro Anticancer and Pharmacokinetic Study
... its bioavailability, in vitro apoptosis and cytotoxicity against breast cancer MCF-7 cells using a top-down technique of ...with improved dissolution rates, in vitro cytotoxicity, and ...relative ...
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Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation
... and drug loading seemed to have no effect on droplet size and self-microemulsifying behavior. Dissolution percent- ages of probucol in SMEDDS in 0.1 M HCl or in pH 7.0 PBS were significantly higher than that of crude ...
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