in- vitro permeability studies
Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies
... In vitro and in vivo studies in Caco-2 cells and in rabbits showed that the microemulsion had significantly improved permeability across Caco-2 cells, a higher peak concentration and AUC, and shorter ...
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Permeability of Novel Chitosan-g-poly (Methyl Methacrylate) Amphiphilic Nanoparticles in a Model of Small Intestine in Vitro
... the permeability phenomenon, which can be divided into two ...the permeability of the nanoparticle across the mucin layer, while the second is the crossing of the epithelial barrier by paracellular (by ...
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Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro
... capillary permeability in several inflammatory conditions, such as brain and myocardium ischemia injury and diabetic retinopathy ...in vitro studies of endothelial cells, MMPs increase paracellular ...
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THE BIOPHARMACEUTICAL CLASSIFICATION SYSTEM (BCS): PRESENT STATUS AND FUTURE PROSPECTIVES
... bioequivalence studies but also for decision making in the discovery and early development of new drugs and formulations ...and permeability in the discovery/development can be utilized for the preliminary ...
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Original Article Permeability of rhynchophylline across human intestinal cell in vitro
... Permeability assay was performed in an air shaking bath (SW 23, Julabo, Seelbach, Germany) at 37°C and 50 rpm to simulate the small intestine motility. The transport experi- ments were carried out in HBSS with 25 ...
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Oxcarbazepine-loaded polymeric nanoparticles: development and permeability studies across in vitro models of the blood–brain barrier and human placental trophoblast
... Abstract: Encapsulation of antiepileptic drugs (AEDs) into nanoparticles may offer promise for treating pregnant women with epilepsy by improving brain delivery and limiting the trans- placental permeability of ...
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DESIGN, CHARECTERIZATION AND IN-VITRO, IN-VIVO CORRELATION STUDIES FOR ELETRIPTAN LOADED TRANSDERMAL PATCHES
... Oral drug delivery is the most desirable route for drug administration whenever systemic effects are intended. But low oral bioavailability of some compounds have prompted the search of more effective routes for their ...
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Acyl lipidation of a peptide: effects on activity and epidermal permeability in vitro
... C 7 -acyl lipid conjugation at either terminal increased the amount of peptide able to cross the skin epidermis compared to that of the parent L-AAPV (Figure 2). The amount of C 7 -acyl lipopeptides detected in the ...
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Effects of Methylglyoxal and Aspirin on In Vitro Coagulation and Clot Permeability
... Methylglyoxal (MGO) can be mentioned as a metabolite of glucose produced from dihydroxyacetone phosphate as a by-product during the formation of glyceraldehyde 3- phosphates in mammalian cells, including vascular smooth ...
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In vitro and in situ absorption studies of vasicine in rats
... and the mean percentage recovery of vasicine from both the extracts in saline was found to be 97±1.14. Luminal disappearance of the drug was determined from the standard curve. The pharmacokinetic graph was plotted by ...
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In Vitro, Ex Vivo Characterization of Furosemide Bounded Pharmacosomes for Improvement of Solubility and Permeability
... XRD studies showed that there was more or less interaction between furosemide and phospholipid and formed some sort of bond that may be covalent bond, hydrogen or van der Waals ...
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<p>In Vitro Intestinal Uptake And Permeability Of Fluorescently-Labelled Hyaluronic Acid Nanogels</p>
... and permeability of the nanogels were studied using in vitro intestinal models with veri fi ed production of mucus, expres- sion of the tight-junction protein occludin and barrier integ- rity – monitored by ...
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DESIGN AND IN VITRO EVALUATION OF TENOXICAM NANOGEL CONTAINING NOVEON POLYMER
... ABSTRACT: The aim of present work is to design a Tenoxicam loaded nanogel for the anti-inflammatory and analgesic effect of prepared nanogel. Tenoxicam is one of the NSAIDs of oxicam class; it is very potent and useful ...
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TRANSDERMAL PATCH OF RAMIPRIL LOADED CHITOSAN NANOPARTICLES DISPERSED IN CARBOPOL GEL
... uptake studies indicated that the increase in the concentration of hydrophilic polymer was directly proportional to the increase in moisture content and moisture uptake of the ...
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In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease
... There exists considerable in vitro and in vivo data supporting differences in the antioxidant, scavenging, and immunomodulatory properties between the different Hp types. Individuals with the Hp2-2 phenotype have ...
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CHLORIDE ION PERMEABILITY STUDIES OF METAKAOLIN BASED HIGH PERFORMANCE CONCRETE
... low permeability that dominates the deterioration process in concrete structures, the resistance to chloride penetration is one of the simplest measures to determine the durability of ...chloride ...
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Development and In-vitro characterization of floating drug delivery system of ketoconazole
... in vitro drug release profiles obtained for tablets (F10) made with combinations of HPC, xathan gum showed a prolonged floating duration (> 12hrs) which was a controlled release characteristic for 12 ...
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FORMULATION AND EVALUATION OF TASTE MASKED FAST DISSOLVING TABLET OF ZOLPIDEM TARTRATE BY DIRECT COMPRESSION METHOD
... In Vitro Dispersion Time: In vitro dispersion time gives direct information regarding the nature of super- disintegrating agent used in the ...In vitro dispersion time is measured by observing the ...
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Icmt inhibition exerts anti-angiogenic and anti-hyperpermeability activities impeding malignant pleural effusion
... We here demonstrate for the first time, that Icmt, besides inhibiting tumor cell growth, may impact certain host-related hallmarks of cancer, i.e. vascular changes and tumor-associated immune response. The ...
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THE IN VITRO PHARMACEUTICAL EQUIVALENCE STUDIES OF LOSARTAN TABLETS OF DIFFERENT MANUFACTURERS AVAILABLE IN BANGLADESH
... The study was aimed to assess the pharmaceutical equivalence of some losartan potassium tablets of different manufacturers marketed in Bangladesh using in vitro dissolution study. The dissolution was carried out ...
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