In Vivo
ANTIOXIDANT ACTIVITY EVALUATION METHODS:IN VITRO AND IN VIVO
... significantly high biological activities in vivo and in vitro. They can directly lead to DNA mutation, alteration of gene expression, modification of cell signal transduction, cell apoptosis, lipid peroxidation ...
7
<p>Formulation design, characterization, and in vitro and in vivo evaluation of nanostructured lipid carriers containing a bile salt for oral delivery of gypenosides</p>
... Results: The optimised formulation yielded nanoparticles with an approximate diameter of 146.7 nm, polydispersity of 0.137, zeta potential of −56.0 mV, entrapment efficiency of 74.22% and drug loading of 4.89%. An in ...
14
In vivo and in vitro evaluation of octyl methoxycinnamate liposomes
... larger amounts of OMC were found on pig ear epidermis following application of a liposomal formulation containing OMC. In their work, approximately 56% of the liposomal OMC applied remained in the epidermis and only 29% ...
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Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate
... in vivo tumor cell apoptosis was investigated by terminal deoxy- nucleotidyl transferase dUTP nick end labeling (TUNEL) assay using an apoptotic cell detection kit (KeyGen Bio- tech, Nanjing, People’s Republic of ...
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In vivo toxicologic study of larger silica nanoparticles in mice
... larger SiNPs are really safer when administered in vivo. Owing to the diverse results of various investigations, we carried out an in vivo study to evaluate the toxic events as well as the dose-related ...
12
Preparation, characterization, and in vitro and in vivo investigation of chitosan-coated poly (d,l-lactide-co-glycolide) nanoparticles for intestinal delivery of exendin-4
... Methods and results: Nanoparticles were prepared using a modified water–oil–water (w/o/w) emulsion solvent-evaporation method, followed by coating with chitosan. The physi- cal properties, particle size, and cell ...
14
<p>In vitro and in vivo mechanism of hepatocellular carcinoma inhibition by beta-TCP nanoparticles</p>
... in vivo, 40 mg/kg of nano- β -TCP was chosen to explore its inhibitory effect on hepatocellular carcinoma in nude mice bearing xeno- grafted HepG2 ...In vivo evaluation of antitumor activity of nano- β -TCP ...
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<p>In vitro and in vivo activity of ciprofloxacin/fosfomycin combination therapy against ciprofloxacin-resistant <em>Shigella flexneri</em> isolates</p>
... To the best of our knowledge, this study is the fi rst to con fi rm that the CIP/FOS combination enhanced in vitro and in vivo activity against CIP R S. fl exneri isolates. This may be due to enhancement of FOS ...
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PREPARATION, CHARACTERIZATION AND IN VITRO - IN VIVO EVALUATION OF GLICLAZIDE LOADED POLYMERIC MICROSPHERES
... Type 2 diabetes mellitus is a heterogeneous disease which involves both defective insulin secretion and peripheral insulin resistance. Despite the availability of other agents for treatment of type 2 diabetes mellitus ...
10
A comparison study of cognitive restructuring + in vivo exposure versus in vivo exposure in the group treatment of agoraphobia.
... In vivo could at least partly be explained In terms of cognitive ...In vivo clients notice, for example, that their anxiety diminishes after a time and that the events which they feared, such as fainting or ...
211
The Effects of MDMA on Brain: An in Vivo Study in Rats
... in vivo brain microdialysis research showed that serotonin concentrations in the extracellular fluid such as cerebrospinal fluid is a suitable indicator reflecting the neuronal activity of the serotonergic system ...
12
FORMULATION AND IN VITRO - IN VIVO EVALUATION OF BILAYER FLOATING-BIOADHESIVE FAMOTIDINE TABLETS
... In vivo antiulcer activity assessment ethanol induced ulcers: In vivo studies on animals were carried our as per the protocol approved by the Animal Ethical Committee of Bombay Veterinary College, Parel ...
8
In vitro and In vivo drug-drug interaction between Sitagliptin phosphate and Atenolol
... The present study was to find out the drug-drug interactions (DDIs) as well as to determine the stability of the complexes, which could be formed after interaction between Sitagliptin phosphate and Atenolol at various ...
9
Nanotherapeutics in angiogenesis: synthesis and in vivo assessment of drug efficacy and biocompatibility in zebrafish embryos
... α v β 3 -targeting ability of RGD serves as a valuable marker of angiogenesis after ischemic injury, myocardial infarction, and inflammation. In this study, RGD-SWCNT conjugates preserved the specific ...
15
<p>In vivo Hepatoprotective and in vitro Radical Scavenging Activities of Extracts of <em>Rumex abyssinicus</em> Jacq. Rhizome</p>
... Background: Liver diseases contribute a prominent global burden of mortality and mor- bidity. The current therapies of liver diseases have numerous limitations including severe adverse effects. This denotes that new more ...
11
Pitavastatin suppressed liver cancer cells in vitro and in vivo
... pitavastatin could be used for liver cancer therapy has never been reported earlier. In our study, we tested the antiliver cancer ability of pitavastatin using cell viability and colony formation assays. Pitavastatin ...
6
Bupivacaine in alginate and chitosan nanoparticles: an in vivo evaluation of efficacy, pharmacokinetics, and local toxicity
... in vivo after the sciatic nerve blockade model and the formulation promoted an increase in the intensity and in the duration of motor and sensory blockades; also, this formula- tion enhanced the differential nerve ...
9
<p>A Correlative Imaging Study of in vivo and ex vivo Biodistribution of Solid Lipid Nanoparticles</p>
... in vivo and ex vivo biodistribution of fl uores- cently labelled nanoparticles by enabling non-invasive detection and quanti fi cation of fl uorescence distributed throughout the whole body of living small ...
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Ex vivo and in vivo evaluation of an ultrasonic device for precise dissection, coagulation, and transection
... For burst pressure measurements, porcine carotid arter- ies of 3–5 mm diameter were selected. Arteries are chosen for burst pressure testing because they experience higher pressures than veins in vivo. During ...
7
Nanoparticles for multimodal in vivo imaging in nanomedicine
... In vivo imaging has made enormous strides in the past 40 ...in vivo optical imaging has been of limited use in humans, it can be combined with MRI or PET and can be used for fluorescence-guided ...
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