in vivo and models
In vivo models in cancer research
... GEM models has proved valuable for assessing the In vivo inhibitory activities and mechanisms of action of various cancer prevention agents at different stages of cancer ...mouse models (GEMMs) have ...
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Learning pharmacokinetic models for in vivo glucocorticoid activation
... inferential models, aiming at grouping individuals in the space of pharmacokinetic models based on observed ...“population” models, that are therefore not defined based on prior knowledge or ...
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EXPERIMENTAL MODELS TO STUDY TUMOUR ANGIOGENESIS – IN VITRO, EX VIVO AND IN VIVO APPROACH
... The impact of different culture conditions can be assessed by spotting the change in the size of the wound area. Cellular behavior is measured for further detailed examination. Spontaneous cell tracking in phase contrast ...
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In vivo Distribution of Inorganic Nanoparticles in Preclinical Models
... plications. In vitro studies have shown that Cadmium Selenium nanocrystals are highly toxic on cell cultures when UV-excited because under UV illumination the highly toxic cadmium ions are released. However, quan- tum ...
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<em>Daphnia magna</em> and<em> Xenopus laevis</em> as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625
... in vivo study exploiting Daphnia magna and Xenopus laevis to evaluate both toxicity and uptake of QDs coated with the membranotropic peptide gH625 derived from the glycoprotein H of herpes simplex virus and widely ...
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In Vivo Animal Models in Preclinical Evaluation of Anti-Inflammatory Activity- A Review
... Inflammation is defined as the local response of living mammalian tissues to injury due to any agent. It is a body defence reaction to prevent the spread of injurious agent and to remove the necrosed cells and tissues. ...
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Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models
... Gastric colonization with Helicobacter pylori induces diverse human pathological conditions, including superficial gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric ...
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Results from in vitro and ex vivo skin aging models assessing the antiglycation and anti-elastase MMP-12 potential of glycylglycine oleamide
... ex vivo studies focused on the architecture of the ECM fiber network and how the latter is protected from glycation when using different antigly- cation ...
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vivo models of dietary-induced atherosclerosis at
... Count data for each sample and species (Supplementary 229.. Principal Component Analysis of gene expression data. Principal components were calculated by singular-value decomposition. P[r] ...
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Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles
... compartment models can be used for pharmacokinetic analysis. The single compartment model depicts the body as a single, kinetically homogeneous unit. The two compartment model assumes that the whole body is ...
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ANTIOXIDANT ACTIVITY EVALUATION METHODS:IN VITRO AND IN VIVO
... significantly high biological activities in vivo and in vitro. They can directly lead to DNA mutation, alteration of gene expression, modification of cell signal transduction, cell apoptosis, lipid peroxidation ...
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An in Vivo Creep Test and Mechanical Modeling in Strabismus
... in vivo behavior studying and viscoelastic properties of horizontal eye muscles in strabismus ...These models can quantify and characterize the creep of medial rectus ...in vivo test method is the ...
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IN VITRO ANTIOXIDANT ACTIVITIES AND IN VIVO ANTI-NOCICEPTIVE AND NEUROPHARMACOLOGICAL ACTIVITIES OF MIMOSA PUDICA
... Neuropharmacological study (Forced swimming test): Forced Swimming test was performed to evaluate the effect of antidepressant effect of Mimosa pudica leaf extracts on mice. After investigation with leaf extracts of ...
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INTRANASAL DRUG DELIVERY – NEW CONCEPT OF THERAPEUTIC IMPLICATIONS FOR EFFECTIVE TREATMENT OF CNS DISORDERS
... ABSTRACT: Intra nasal drug delivery system (INDDS) has emerged as a non- invasive alternative for delivering peptides, proteins and other therapeutic agents, specifically to CNS (Central nervous system). This route is ...
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<p>In vitro and in vivo Biological Responses to Graphene and Graphene Oxide: A Murine Calvarial Animal Study</p>
... in vivo mice calvarial osteolysis model to test the effects of new biomaterial particles on the biological response to the bone ...in vivo effects of graphene and GO particles via our previously developed ...
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IN VITRO AND IN VIVO EFFICACY OF ROOT EXTRACT OF LAWSONIA INERMIS AGAINST INFLAMMATORY PARADIGM
... membrane stabilization activity, LILAC at the concentration of 100 µg/ml and 200µg/ml exhibited membrane stabilizing activity. Acute oral toxicity of extract was determined by OECD 423 guidelines wherein mortality was ...
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BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies
... same models of branching morphogenesis, BMP7 has been shown to have a stimulatory effect at low doses whereas high doses are inhibitory to growth and branching (Piscione et ...
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Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis
... KBP-7018 is a recently identified potent new compound for the treatment of IPF, which is currently under preclini- cal development. Compared with nintedanib, the approved kinase inhibitor in IPF, KBP-7018, showed better ...
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Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream
... Introduction: During recent years, there has been growing interest in use of topical vehicle systems to assist in drug permeation through the skin. Drugs of interest are usually those that are problematic when given ...
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<p>Preparation and in vitro and in vivo Study of Asiaticoside-Loaded Nanoemulsions and Nanoemulsions-Based Gels for Transdermal Delivery</p>
... In this study, SLD was successfully used to optimize the composition of the ASI-NEs formulation. According to the ex vivo permeation study, the ASI-NEs exhibited signi fi cantly higher transdermal permeation than ...
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