inactive X chromosome
Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells
... Mammalian X-chromosome inactivation (XCI) enables dosage compensation between XX females and XY ...to X-linked gene dosage in extra-embryonic tissues is difficult to reconcile with the reported ...
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Normal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteins
... the inactive X chromosome that are associated with genes [23] and LINE-1 elements ...the inactive X should not be modified to a silent form in ICF ...the inactive X ...the ...
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Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells
... regulation, X chromosome inactivation and parental ...the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES ...
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PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice
... mouse X-chromosome ...the inactive X ...the inactive X ...inactivated X-linked genes is derepressed in Eed –/– ...the inactive-X, including RNA PolII, ...
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Loss of SETDB1 decompacts the inactive X chromosome in part through reactivation of an enhancer in the IL1RAPL1 gene
... the X chromosome site-C; gRNA: guide RNA; H3K4me2: histone H3 dimethylated lysine 2; H3K9me3: histone H3 trimethyl- ated at lysine 9; H3K27Ac: histone H3 acetylated at lysine 27; H3K27me3: histone H3 ...
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The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation
... RNA-seq indexed libraries were prepared using Illumina TruSeq RNA sample preparation kit for two biological replicates from control or stable knockdown (si&shRNA) Patski cells, respectively. Libraries from two ...
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Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion
... because X-inactivation is intact along the entire chromosome in a majority of cells, and the small fraction of cells that express MeCP2-EGFP have lost silencing along the entire chromosome, or ...
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The Trithorax group protein Ash2l and Saf A are recruited to the inactive X chromosome at the onset of stable X inactivation
... for X chromosome-wide histone H4 hypoacetylation, we performed immunofluorescence staining on native chromosome spreads of SX ES cells that were differentiated for 1, 3 or 5 ...Hypoacetylated ...
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Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X inactivated state in mice
... inactivated X chromosome. Although the X chromosome undergoing inactivation initially shifts its replication timing from early to late S phase as usual even in the absence of SmcHD1, the ...
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Bipartite structure of the inactive mouse X chromosome
... The inactive X chromosome (Xi) becomes highly condensed compared with the active X (Xa) and forms the Barr body, often vis- ible as a dense region within the nucleus ...the X ...
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Nonrandom X Chromosome Inactivation Is Influenced by Multiple Regions on the Murine X Chromosome
... the inactive X ...future inactive X chromo- some, where Xist RNA coats the X chromosome and facilitates spreading of inactivation of genes in ...active X ...
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Skewed X-chromosome inactivation in scleroderma.
... the inactive X chromosome in those patients with extremely skewed ...skewed X-inactivation and both maternal and fetal microchimerism was examined in a well-characterized cohort of scleroderma ...
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Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing
... the inactive X, based on a series of immunofluorescence ...an X-linked reporter allele in murine cells, while immunofluorescence with a new antibody showed H3K9me2 enriched on the puta- tive Xi, as ...
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CHROMOSOME STRUCTURE X. AN X-RAY EXPERIMENT
... D, quartet stage (only one of the two chromo- somes which separate in the second division is shown). E, metaphase in first division of the pollen grain. Another multiplicat[r] ...
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Sex determination in polyploids of Caenorhabditis elegans.
... was not directly determined. Experiments involving X chromosome duplications in triploids: For testing the effect of an X chromosome dupli- cation, diploid males hete[r] ...
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Distal Xq duplication and functional Xq disomy
... tions. Giglio et al. described four der(X) chromosomes and proposed recombination between inverted repeat sequences during paternal meiosis as mechanism of ori- gin [45]. However, non-recurrent aberrations can ...
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Fluorescent molecular cytogenetics: Preimplantation diagnosis, colorectal cancer and mapping chromosome 9q.
... These probes have been applied to the study of preimplantation embryos. Jones et al (1987) used both radioactive and non-radioactive approaches, the non-isotopic technique employed enzymatic (i.e. alkaline phosphatase) ...
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THE MEIOTIC BEHAVIOR OF TANDEM ACROCENTRIC COMPOUND X CHROMOSOMES IN DROSOPHILA MELANOGASTER
... compound X chromosome consists of two X chromosomes joined to form a A single chromosome containing one centromere, two euchromatically complete (or almost complete) X chrom[r] ...
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REARRANGEMENT OF GENES LOCATED ON HOMOLOGOUS CHROMOSOMAL SEGMENTS IN MOUSE AND MAN: THE LOCATION OF GENES FOR ALPHA-AND BETA-INTERFERON, ALPHA-1 ACID GLYCOPROTEIN-1 AND -2, AND AMINOLEVULINATE DEHYDRATASE ON MOUSE CHROMOSOME 4
... For example, conserved synteny of genes located on the X chromosome among mammals provides strong evidence that chromosomal rearrangements between the X chromosome [r] ...
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Low RNA Binding Strength of Human X Chromosome May Explain X Chromosome Inactivation
... the X chromosome in eutherians and the copy number of L1 in X chromosome was higher than that in the autosomes ...one X chromosome, approximately 30% of genes located on the ...
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