Indian hedgehog
Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP
... In the developing growth plate, periarticular chondrocytes proliferate, differentiate into columnar chondrocytes, and then further differentiate into postmitotic hypertrophic chondrocytes. Parathyroid hor- mone–related ...
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Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate
... involving hedgehog proteins, wingless-related proteins and fibroblast growth factors remains ...diminished Indian hedgehog (Ihh) signaling and abnormal Ihh protein distribution in the extracellular ...
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Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1 CreERT2; Ihhfl/fl mice
... Indian hedgehog (Ihh), may be involved because bloc- king hedgehog (Hh) signaling with an inhibitor attenu- ated OA progression ...Sonic hedgehog and Desert hedgehog, which all share ...
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Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules
... therapy. Hedgehog (HH) signaling plays an important role during the development of ...of Indian hedgehog (IHH), Patched-1 (PTC1) and GLI family members GLI1, GLI2, GLI3 in ...
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Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
... Indian hedgehog (Ihh) is a member of the hedgehog (Hh) family that plays crucial roles in regulating many developmental processes. Ihh is one of the key signaling molecules controlling both ...
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Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway
... in Indian hedgehog (Ihh) protein expression in human osteoarthritic cartilage, which promotes chondrocyte hypertrophy and the upregulation of matrix metallopep- tidase 13 (MMP-13) ...of hedgehog (Hh) ...
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An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
... and TA cell populations. Although Shh has not yet been shown to directly influence the stem cell population of the skin, it is well characterised that mammalian Shh, normally expressed in the basal cells of the skin, ...
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Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells
... Remarkably, despite the fast-growing body of literature on this topic, no single most-appropriate factor and deliv- ery method has been identified for the purpose of hyaline cartilage regeneration that justified approval ...
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Using EC and ES cell culture to study early development: recent observations on Indian hedgehog and Bmps
... only hedgehog gene expressed in F9 embryoid bodies, indicating that the cross-reacting antibody is recognizing only IHH and not DHH or SHH peptide in these cultures (Becker et ...
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Synergistic effect of Indian hedgehog and bone morphogenetic protein-2 gene transfer to increase the osteogenic potential of human mesenchymal stem cells
... smoothened, hedgehog signal transduction occurs via members of the Gli family of zinc-finger transcrip- tion factors (Gli1, 2, and 3) ...The hedgehog pathway was previously reported to be involved in ...
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Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development
... endothelial cells still surrounded the mutant cartilage condensations, the lack of hedgehog signaling adversely affected their subsequent development. For example, while PECAM-positive endothelial cells normally ...
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Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development
... By comparing PTH/PTHrP receptor–/–/wild-type PPR–/–/wild-type chimeric mice with Ihh–/–;PPR–/–/wild-type chimeric and Ihh–/–/wild-type chimeric mice, we provide in vivo evidence that Ind[r] ...
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Adipocyte nuclei captured from VAT and SAT
... IHH, Indian Hedgehog Homolog), IKZF1 (IKAROS family zinc finger protein 1; ILF3, interleukin enhancing binding factor 3; KLF2, zinc finger transcription factor Kruppel-Like Factor 2; LEP, leptin, obesity ...
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Hedgehog Signalling in the Embryonic Mouse Thymus
... 1. Hedgehog (Hh) expression in different microenvironments as thymocytes migrate through the embryonic ...of Indian hedgehog (Ihh, expressed by double positive (DP) thymocytes) are shown in green, ...
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Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin 1β
... The hedgehog signalling pathway has also been impli- cated in the pathogenesis of OA ...cartilage, hedgehog pathway activation requires the binding of Indian hedgehog (Ihh) to its ...
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Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification
... and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) degeneration is ...and hedgehog ...
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An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression
... Sonic hedgehog (Shh) ...in Indian hedgehog ...of hedgehog target genes such as Gli1-3, patched, and Pthlh, as well as the downregulation of Ihh and ...
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Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling
... HH: Hedgehog; HHIP: Hedgehog-interacting protein; HSC: Hematopoietic stem cell; HSPCs: Hematopoietic stem and progenitor cells; IHH: Indian Hedgehog; ITD: Internal tandem duplications; MDS: ...
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A highlight on Sonic hedgehog pathway
... Hh: Hedgehog; IFT80: Intraflagellar transport protein 8; Ihh: Indian-Hedgehog; MB: Medulloblastoma; Mek1: Mitogen activated protein kinase kinase; MGMT: O-6-methylguanine-DNA methyltransferase; NSCs: ...
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Gastric cancer and Hedgehog signaling pathway: emerging new paradigms
... Drosophila, hedgehog signaling has been linked to foregut development, The mammalian genome expresses three Hedgehog paralogues, sonic hedgehog (Shh), Indian Hedgehog, and desert ...
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