Individual participant data meta-analyses
Individual participant data meta analyses should not ignore clustering
... survival data with cen- soring also produce downwardly biased treatment effect es- timates when important covariates are ...IPD meta-analysis community, many of whom currently ignore clustering ...IPD ...
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Aspirin has potential benefits for primary prevention of cardiovascular outcomes in diabetes: updated literature-based and individual participant data meta-analyses of randomized controlled trials
... of data from general and secondary prevention populations suggests that the main adverse effect associ- ated with aspirin use is GI bleeding ...current data suggests otherwise, real-world data in ...
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Diverse types of review studies based on their approach to retrieving and summarizing original findings
... In this new type of investigation, which is not a review study, high-quality original studies with similar design and reporting guidelines are carried out in different communities. The chief aim of such a design is to ...
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Text2PreventCVD: protocol for a systematic review and individual participant data meta-analysis of text message-based interventions for the prevention of cardiovascular diseases
... and analyses and will have opportunities to network and identify future Text2Prevent research questions suitable for ana- ...the data collection proforma; secure data handling; review the publication ...
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Is self-guided internet-based cognitive behavioural therapy (iCBT) harmful? : An individual participant data meta-analysis
... To identify eligible studies, we used an existing database of trials focusing on psychological therapies for adults with depression (Cuijpers et al. 2008). This database was developed in 2006 and is updated annually by a ...
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Simulation-based power calculations for planning a two-stage individual participant data meta-analysis
... IPD meta-analyses are both time-consuming and expensive to perform, requiring significant resources to obtain, clean and harmonise the IPD from relevant trials before then synthesising them; a process that ...
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Acceptance and commitment therapy for chronic pain: protocol of a systematic review and individual participant data meta-analysis
... A meta-analysis of individual participant data (IPD, here- inafter referred as IPD-MA) may therefore be a reliable method to overcome high heterogeneity across ...of analyses and ...
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Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol
... an individual participant data meta- analysis to explore the magnitude of survival benefit and address whether subgroups of patients are more likely to benefit from parenteral ...All ...
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Which patients benefit specifically from short-term psychodynamic psychotherapy (STPP) for depression? Study protocol of a systematic review and meta-analysis of individual participant data
... primary data, access to predictor or moder- ator variables that might not have been reported in the published articles is gained; increasing the chance that aggregation of these variables across studies is ...IPD ...
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Pregnancy as a risk factor for severe influenza infection: an individual participant data meta analysis
... our data did not provide consistent support for pregnancy being an independent risk factor for se- vere influenza disease across ...for individual-level characteristics in this ...sensitivity ...
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The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data
... two-stage individual participant data meta-analysis to allow for consistent definitions and analyses across the cohorts, increased analytical flexibility, and decreased complexity of ...
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The acute effects of physical activity on cigarette cravings: Systematic review and meta analysis with individual participant data
... for baseline values of SoD and DtS, included fewer studies in the meta-analyses (9 and 10 for SoD and DtS respectively) and also included a study with participants using NRT (40). Similarity of the results ...
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Exercise therapy for chronic low back pain: protocol for an individual participant data meta-analysis
... literature. Meta- analysis, which is the quantitative synthesis of data from primary studies, is valuable to increase the number of patients (statistical power/precision) available to esti- mate a treatment ...
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Individual participant data meta-analysis of prognostic factor studies: state of the art?
... IPD meta-analyses of prognostic factors were identified up to March ...IPD meta-analyses of prognostic factor studies are often needed; in particular, continuous variables are often ...
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The effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on longer-term maternal and early childhood outcomes: protocol for an individual participant data (IPD) meta-analysis
... meaningful meta-analysis to occur, the intensity of the intervention provided and so- cial demographics of included participants is diverse with the IPD proposed enabling identification of effect modifiers through ...
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Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta analysis of randomized trials
... an individual participant data meta-analysis of high quality randomized, double- blind, placebo-controlled trials of progestogen treatment in women with a twin ...Missing data will be ...
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Malaria, malnutrition, and birthweight: A meta analysis using individual participant data
... tion analyses, we chose to focus on malaria infection at enrollment instead of at delivery for 2 ...sensitivity analyses, we explored alternative defini- tions of malaria, including any PCR results and “any ...
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The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation
... Once maternal longer-term outcomes are included in the value of information analysis, there is a high value to further research at a cost-effectiveness threshold of £20,000 per QALY. The EVPI (accounting for the 700,000 ...
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Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta analysis of individual participant data
... IPD meta-analy- sis, since any negative signal from a modest number of additional participants would likely be diluted by the robust protective signal generated from analysis of data from nearly 11 000 ...
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