indoleamine 2
Epstein-Barr Virus Infection Induces Indoleamine 2,3-Dioxygenase Expression in Human Monocyte-Derived Macrophages through p38/Mitogen-Activated Protein Kinase and NF-κB Pathways: Impairment in T Cell Functions
... CD8 ⴙ cytotoxic T lymphocytes (CTLs) play an important role in the control of viral infections and destroy tumor cells. Activa- tion of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in ...
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Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
... Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally referred ...
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Inhibition of experimental asthma by indoleamine 2,3 dioxygenase
... Epidemiological evidence points to the inverse relationship between microbial exposure and the prevalence of allergic asthma and autoimmune diseases in Westernized countries. The molecular basis for this obser- vation ...
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Upregulation of Indoleamine 2,3-Dioxygenase in Hepatitis C Virus Infection
... Indoleamine 2,3-dioxygenase (IDO) mediates conversion of tryptophan to catabolites collectively known as kynurenines (22). This enzyme is expressed by both epithelial and dendritic cells induced by proinflammatory ...
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Indoleamine 2,3 dioxygenase and tumor induced tolerance
... Tumors arise from normal cells of the body through genetic mutation. Although such genetic mutation often leads to the expression of abnormal antigens, the immune system fails to respond effectively to these antigens; ...
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B7 costimulation and intracellular indoleamine 2,3 dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non pregnant women
... Besides initiating signal transduction in T lymphocytes, B7-1 and B7-2 may back-signal into the APC and influ- ence the local immune environment through induced ex- pression of immunosuppressive factors ...
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Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors
... Abstract: Nanomedicine application in cancer immunotherapy is currently one of the most challenging areas in cancer therapeutic intervention. Innovative solutions have been provided by nanotechnology to deliver cytotoxic ...
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Brain indoleamine 2,3 dioxygenase contributes to the comorbidity of pain and depression
... Pain and depression are frequently comorbid disorders, but the mechanism underlying this association is unknown. Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryp- ...
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H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma
... Indoleamine 2,3-dioxygenase 1 (IDO1), a ubiquitous mono- meric heme-containing enzyme, is the first rate-limiting en- zyme in the kynurenine pathway (KP) that catabolizes tryptophan (Trp) into kynurenine [1]. ...
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Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth
... Indoleamine 2,3-dioxygenase 2 (IDO2) is a newly discovered enzyme that catalyzes the initial and rate-limiting step in the degradation of tryptophan. As a homologous protein of IDO1, IDO2 plays an ...
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Original Article Expression and function analysis of indoleamine 2 and 3-dioxygenase in bladder urothelial carcinoma
... Abstract: Indoleamine 2, 3-dioxygenase (IDO) is a rate-limiting enzyme for tryptophan metabolism inducing immune tolerance of tumors. The purpose of this study is to investigate IDO expression and its ...
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Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells
... identified. Indoleamine 2, 3-dioxygenase (IDO/INDO), an impor- tant enzyme in the metabolism of tryptophan, catalyzes the rate-limiting step of tryptophan degradation along the kynurenine ...
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Expression and regulation of immune modulatory enzyme Indoleamine 2,3 dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
... Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally referred ...
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Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-α and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats
... Objectives: This study aimed to investigate the role of tumor necrosis factor (TNF)-α and the neuronal nitric oxide synthase enzyme in dysregulation of indoleamine 2,3-dioxygenase (ID[r] ...
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A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase
... of indoleamine 2,3-dioxygenase by lipopoly- saccharide: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways, and synergistic effect of several proinflammatory ...
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Lavender oil suppresses indoleamine 2,3 dioxygenase activity in human PBMC
... Importantly, immune activation and inflammation are strongly associated with an increase of mood disorders [11,12]. Several biochemical links between psychoneuro- immunology and neuropsychopharmacology have been ...
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Serum Indoleamine 2,3-Dioxygenase Activity Predicts Prognosis of Pulmonary Tuberculosis
... Indoleamine 2, 3-dioxygenase (IDO) is the rate-limiting en- zyme that catalyzes tryptophan (Trp) degradation along the kynurenine (Kyn) pathway (9, 11, 12, 19, ...
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The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection
... research. Indoleamine 2,3-dioxygenase (IDO) has been shown to act as a molecular switch regulating host responses, and IDO inhibitor drugs shown to possess potential in enhancing host immunity to established ...
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Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures
... LPS was not motivated by consideration of the possible role of this brain area in major depressive disorders [27,47,48] but by the need to compare ex vivo data to in situ data collected in OHSCs. Compared to primary cul- ...
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Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1 in juvenile diabetes
... Kyn assay, real-time PCR, immunoblot analysis, and cytokine determination. IDO1 activity was measured in terms of the ability to metabolize Trp to Kyn, whose concentration was measured by HPLC in super- natants of PBMCs ...
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