Indoleamine 2,3-dioxygenase
Indoleamine 2,3 dioxygenase and tumor induced tolerance
... Tumors arise from normal cells of the body through genetic mutation. Although such genetic mutation often leads to the expression of abnormal antigens, the immune system fails to respond effectively to these antigens; ...
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Brain indoleamine 2,3 dioxygenase contributes to the comorbidity of pain and depression
... Pain and depression are frequently comorbid disorders, but the mechanism underlying this association is unknown. Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in ...
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B7 costimulation and intracellular indoleamine 2,3 dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non pregnant women
... Besides initiating signal transduction in T lymphocytes, B7-1 and B7-2 may back-signal into the APC and influ- ence the local immune environment through induced ex- pression of immunosuppressive factors ...
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Expression and regulation of immune modulatory enzyme Indoleamine 2,3 dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
... Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally ...
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Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
... Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally ...
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Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-α and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats
... Objectives: This study aimed to investigate the role of tumor necrosis factor (TNF)-α and the neuronal nitric oxide synthase enzyme in dysregulation of indoleamine 2,3-dioxygenase (ID[r] ...
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A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase
... enzyme indoleamine 2,3-dioxygenase is induced by proinflammatory cytokines and may form a link between immune functioning and altered neurotransmission, which results in ...Increased indoleamine ...
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H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma
... Indoleamine 2,3-dioxygenase 1 (IDO1), a ubiquitous mono- meric heme-containing enzyme, is the first rate-limiting en- zyme in the kynurenine pathway (KP) that catabolizes tryptophan (Trp) into kynurenine ...
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Lavender oil suppresses indoleamine 2,3 dioxygenase activity in human PBMC
... Importantly, immune activation and inflammation are strongly associated with an increase of mood disorders [11,12]. Several biochemical links between psychoneuro- immunology and neuropsychopharmacology have been ...
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Serum Indoleamine 2,3-Dioxygenase Activity Predicts Prognosis of Pulmonary Tuberculosis
... Indoleamine 2, 3-dioxygenase (IDO) is the rate-limiting en- zyme that catalyzes tryptophan (Trp) degradation along the kynurenine (Kyn) pathway (9, 11, 12, 19, ...
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Upregulation of Indoleamine 2,3-Dioxygenase in Hepatitis C Virus Infection
... Indoleamine 2,3-dioxygenase (IDO) mediates conversion of tryptophan to catabolites collectively known as kynurenines (22). This enzyme is expressed by both epithelial and dendritic cells induced by ...
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Epstein-Barr Virus Infection Induces Indoleamine 2,3-Dioxygenase Expression in Human Monocyte-Derived Macrophages through p38/Mitogen-Activated Protein Kinase and NF-κB Pathways: Impairment in T Cell Functions
... Epstein-Barr virus (EBV) infection has been observed in tumor-infiltrated macrophages, but its infection effects on macrophage immune functions are poorly understood. Here, we showed that some macrophages in the tumor ...
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The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection
... research. Indoleamine 2,3-dioxygenase (IDO) has been shown to act as a molecular switch regulating host responses, and IDO inhibitor drugs shown to possess potential in enhancing host immunity to ...
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Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors
... Abstract: Nanomedicine application in cancer immunotherapy is currently one of the most challenging areas in cancer therapeutic intervention. Innovative solutions have been provided by nanotechnology to deliver cytotoxic ...
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Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase
... RAW 264.7 cells (BALB/c mouse macrophage cell line) were a gift from Dr. David Greaves (Sir William Dunn School of Pathology, University of Oxford, United Kingdom). The cell culture media contained Iscove's Modified ...
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Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells
... Foxp3 gene expressions in T cells from different co-cul- tures were also assessed by quantitative real-time RT- PCR using b -actin mRNA as an internal control. Foxp3 primers, sense 5 ’ -CCCACTTACAGGCACTCCTC-3 ’ ; ...
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Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures
... Hippocampal slice cultures were prepared using the sta- tic interface culture method [39]. Briefly, 6- to 8-day-old C57BL/6J mice were euthanized by decapitation. The brains and meninges were removed, followed by separa- ...
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Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1 in juvenile diabetes
... Occurrence of abnormal expression of IL-6R and SOCS3 in PBMCs from T1D patients. In mouse DCs (18), proin- flammatory IL-6 drives regulatory proteolysis of IDO1 via upregulation of SOCS3, a small molecule capable of ...
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Cancer/stroma interplay via cyclooxygenase 2 and indoleamine 2,3 dioxygenase promotes breast cancer progression
... for 3 mi- nutes, and the conditions for PCR were 28 cycles of de- naturation (95°C/1 minute), annealing (60°C/1 minute) extension (72°C/1 minute), and 1 cycle of final extension (72°C/10 ...2,3- dioxygenase ...
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Different Partners, Opposite Outcomes: A New Perspective of the Immunobiology of Indoleamine 2,3-Dioxygenase
... phosphatidylinositol 3-kinase–dependent signaling, TGF- β ac- tivates Fyn (a tyrosine kinase belonging in the Src family) that phosphorylates the ITIM domains in ...
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