INDOLINE-3
![Synthesis and crystal structures of 5'-phenylspiro[indoline-3, 2'-pyrrolidin]-2-one derivatives](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Synthesis and crystal structures of 5'-phenylspiro[indoline-3, 2'-pyrrolidin]-2-one derivatives
... stereoselective 3 ’ -Phenyl-4 ’ - nitro-5 ’ -phenylspiro[indoline-3,2 ’ -pyrrolidin]-2-one or 3 ’ - (4-Methoxyphenyl)-4 ’ -nitro-5 ’ -phenylspiro[indoline-3,2 ’ ...
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5 Chloro 5′′ (4 chlorobenzylidene) 4′ (4 chlorophenyl) 1′,1′′ dimethyldispiro[indoline 3,2′ pyrrolidine 3′,3′′ piperidine] 2,4′′ dione
... A mixture of equimolar amounts of 3E,5E-3,5-bis(4-chlorophenylmethylidene)-1-methyl-4-piperidone (5 mmol) [prepared by a literature procedure (Modzelewska et al., 2006)], 5-chloroisatin and sarcosine in absolute ethanol ...
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Methyl (3R*,3′S*) 1′,1′′ dimethyl 2,2′′ dioxodispiro[indoline 3,2′ pyrrolidine 3′,3′′ indoline] 4′ carboxylate
... ring adopts an envelope conformation with the N atom in the flap position. The indoline ring systems are almost perpendic- ular to the mean plane of the pyrrolidine ring, making dihedral angles of 86.4 (8) and ...
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Methyl 4′ (4 fluorophenyl) 1′ methyl 3′ nitromethyl 2 oxospiro[indoline 3,2′ pyrrolidine] 3′ carboxylate
... A mixture of (E)-methyl 3-(4-fluorophenyl)-2-(nitromethyl)acrylate (1 mmol, 0.24 g), isatin (1 mmol, 0.15 g) and sarcosine (1 mmol, 0.09 g) in acetonitrile (6 ml) was refluxed for 14 h. After completion of the ...
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Crystal structure of methyl 1 methyl 2 oxospiro[indoline 3,2′ oxirane] 3′ carboxylate
... O2 0.0454 (10) 0.0440 (9) 0.0450 (9) −0.0086 (7) 0.0076 (7) 0.0005 (7) O4 0.0565 (11) 0.0523 (11) 0.0456 (10) 0.0033 (8) 0.0026 (8) −0.0115 (8) O3 0.0524 (13) 0.0730 (13) 0.0597 (12) 0.0065 (9) 0.0068 (9) −0.0112 (9) O1 ...
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Methyl 3′ benzyl 4′ (2,4 dichlorophenyl) 1′ methyl 2 oxo 1 propylspiro[indoline 3,2′ pyrrolidine] 3′ carboxylate
... Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 ...
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Methyl 3′ benzyl 4′ (2 chlorophenyl) 1′ methyl 2 oxospiro[indoline 3,2′ pyrrolidine] 3′ carboxylate
... Cl1 0.0585 (3) 0.0513 (3) 0.0387 (2) −0.0011 (2) 0.00890 (18) −0.00687 (17) O1 0.0440 (6) 0.0340 (6) 0.0505 (6) −0.0111 (5) 0.0216 (5) −0.0061 (5) O2 0.0317 (5) 0.0397 (6) 0.0438 (6) −0.0094 (4) −0.0005 (4) ...
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Methyl 3′ benzyl 4′ (2,4 dichlorophenyl) 1′ methyl 2 oxospiro[indoline 3,2′ pyrrolidine] 3′ carboxylate
... C1 0.0388 (9) 0.0436 (9) 0.0367 (9) −0.0069 (7) 0.0025 (7) 0.0008 (7) C2 0.0367 (9) 0.0496 (11) 0.0534 (11) −0.0066 (7) 0.0082 (8) −0.0034 (8) C3 0.0468 (10) 0.0445 (10) 0.0570 (11) −0.0149 (8) 0.0214 (9) −0.0047 (8) C4 ...
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Methyl 3′ (2,5 dimethylbenzyl) 1′ methyl 2 oxo 4′ phenylspiro[indoline 3,2′ pyrrolidine] 3′ carboxylate chloroform monosolvate
... Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 ...
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Methyl 4 (4 bromoanilino) 2′,5 dioxo 5H spiro[furan 2,3′ indoline] 3 carboxylate
... Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 ...
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4′ (1H Imidazol 2 yl) 3′ [(1H indol 3 yl)carbonyl] 1′ methyl 2 oxospiro[indoline 3,2′ pyrrolidine] 3′ carbonitrile 0 15 hydrate
... A mixture of isatin (1 mmol), sarcosine (1.2 mmol) and 3-(1H-imidazol-2-yl)-2-(1H-indole-3-carbonyl)acrylonitrile (1 mmol) were refluxed in ethanol (30 ml). After completion of the reaction as evidenced by ...
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Crystal structure of 3′ (1H indole 3 carbonyl) 1′ methyl 2 oxo 4′ (4 oxo 4H chromen 3 yl)spiro[indoline 3,2′ pyrrolidine] 3′ carbonitrile
... A mixture of isatin2a-f (1.0 mmol), sarcosine3 (1.1 mmol) and (E)-2-(1H-indole -3-carbonyl)-3-(4-oxo-4H-chromen-3- yl)acrylonitrile 1 (1.2 mmol) in methanol was stirred at room temperature for 120 ...
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3′ [(1H Indol 3 yl)carbonyl] 1′ methyl 2 oxo 4′ (thiophen 2 yl)spiro[indoline 3,2′ pyrrolidine] 3′ carbonitrile
... In the title compound, fig. 1, the central pyrrolidine ring adopts a twisted conformation on bond C8-C9 with puckering parameters (Cremer and Pople, 1975) of q(2) = 0.407 (3)Å and φ(2) = 133.5 (4)°. Atoms C8 and ...
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5′′ Benzylidene 5 chloro 1′,1′′ dimethyl 4′ phenyldispiro[indoline 3,2′ pyrrolidine 3′,3′′ piperidine] 2,4′′ dione
... of the plane of the remaining five atoms (r.m.s. deviation = 0.086 Å). The C6 and C8 atoms occupy axial and equatorial positions with respect to the piperidine ring, the phenylmethylidene residue occupies an equatorial ...
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Methyl (3S,3′R) 1 methyl 2,2′′ dioxo 1′,2′,3′,5′,6′,7′,8′,8a′ octahydrodispiro[indoline 3,2′ indolizine 3′,3′′ indoline] 1′ carboxylate
... Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 ...
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Methyl 5′′ chloro 1′,1′′ dimethyl 2,2′′ dioxodispiro[indoline 3,2′ pyrrolidine 3′,3′′ indoline] 4′ carboxylate
... [N1/C1-C8 and N3/C12-C19] make dihedral angles of 77.7 (8) ° and 86.1(68° with respect to the mean plane of the central pyrrolidine ring system [N2/C7/C9/C10/C12]. This clearly shows that the indoline ring ...
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1 Ethyl 4′ (1H indol 3 ylcarbonyl) 1′ methyl 2,2′′ dioxodispiro[indoline 3,2′ pyrrolidine 3′,3′′ indoline] 4′ carbonitrile dimethyl sulfoxide monosolvate
... 0.402 (2)Å, φ(2) = 331.4 (3)°, and with atom C13 deviating by 0.256 (2)Å from the mean plane passing through the rest of the ring atoms (Cremer & Pople, 1975). The carbonitrile group is nearly perpendicular to ...
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A triclinic polymorph of methyl (3R,3′S) 1′,1′′ dimethyl 2,2′′ dioxodispiro[indoline 3,2′ pyrrolidine 3′,3′′ indoline] 4′ carboxylate
... C1 0.1180 (16) 0.0905 (13) 0.0559 (10) −0.0537 (12) 0.0155 (10) −0.0508 (10) C2 0.0382 (5) 0.0283 (5) 0.0297 (5) −0.0120 (4) 0.0025 (4) −0.0110 (4) C3 0.0304 (4) 0.0215 (4) 0.0268 (5) −0.0134 (3) 0.0023 (3) ...
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3′ [Hydroxy(4 oxo 4H chromen 3 yl)methyl] 2 oxospiro[indoline 3,2′ pyrrolidine] 3′ carbonitrile
... half-chair conformation, while the pyrrolidine (with a C atom as the flap atom) and the five-membered ring in the indoline (with a C atom as the flap atom) ring system adopt slight envelope conformations. The ...
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Application of Mn(III) Oxidative Cyclizations to Natural Product Synthesis
... substrate to our manganese cyclization conditions would allow us to access the advanced intermediate 3-40. Building of the second cyclohexane ring required to form 3-41 could be completed by addition of ...
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