Indoxyl sulfate
Indoxyl sulfate promotes apoptosis in cultured osteoblast cells
... Indoxyl sulfate (IS) is an organic anion uremic toxin be- longing to the family of protein-bound retention solutes [1]. IS is synthesized in the liver from indole, which is produced from the metabolism of ...
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Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB
... Results: Indoxyl sulfate downregulated Nrf2 expression in HK-2 ...The indoxyl sulfate-induced downregulation of Nrf2 expression was alleviated by an inhibitor of nuclear factor- κ B (NF- κ B) ...
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Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters
... Abstract: Indoxyl sulfate (IS), a putative low-molecular weight uremic toxin, is excreted in the urine under normal kidney function, but is retained in the circulation and tissues during renal dysfunction ...
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Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease
... of indoxyl sulfate, the vast majority of parameters affecting hemostasis, and markers of renal insufficiency conditions were ...of indoxyl sulfate were independently associated with markers of ...
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Changes in serum indoxyl sulfate levels after acute myocardial infarction and the correlation with kidney injury: an observational study
... IS: Indoxyl sulfate; KIM-1: Kidney injury molecule-1; L-FABP: Liver-type fatty acid-binding protein; LVEF: Left ventricular ejection fraction; MI: Myocardial infarction; NGAL: Neutrophil ...
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Limited Effect of Intravenously Administered Indoxyl Sulfate, a Uremic Toxin, on the Hepatic Transport of Pravastatin in Normal Rats
... [1] Vanholder, R., De Smet, R., Glorieux, G., Argilés, A., Baurmeister, U., Brunet, P., Clark, W., Cohen, G., De Deyn, P.P., Deppisch, R., Descamps-Latscha, B., Henle, T., Jörres, A., Lemke, H.D., Massy, Z.A., ...
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Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study
... IS: Indoxyl sulfate; KDIGO: Kidney Disease: Improving Global Outcomes; MDRD: Modification of diet in renal disease; OATs: Organic anion transporters; RBC: Red blood cell; RRT: Renal replacement therapy; ...
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Effect of astragaloside IV on indoxyl sulfate-induced kidney injury in mice via attenuation of oxidative stress
... IS: Indoxyl sulfate; NF- κ B: Nuclear factor- κ B; RIPA: Radio-Immunoprecipitation Assay; SDS-PAGE: dodecyl sulfate, sodium salt-Polyacrylamide gel ...
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Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease
... unclear. Indoxyl sulfate (IS) can reduce renal Klotho expression through CpG hypermethylation of the Klotho gene, suggesting that epigenetic modification of Klotho gene may be an important mechanism of ...
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Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate
... of indoxyl sulfate on phosphatidylserine exposure and ...of indoxyl sulfate (5 – 600 μ ...of indoxyl sulfate for the respective measurements ...
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Role of anuria in the relationship between indoxyl sulfate and anemia in peritoneal dialysis patients
... Background: Experimental evidence suggests that indoxyl sulfate (IS) is associated with chronic kidney disease-related anemia. However, clinical studies are limited, and few have explored the potential ...
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Indole 3-acetic acid, indoxyl sulfate and paracresyl-sulfate do not influence anemia parameters in hemodialysis patients
... The role of indolic toxins or paracresyl-sulfate (PCS) in anemia has recently been proposed. Indoxyl sulfate (IS) and indole-3-acetic acid (IAA) are protein bound in- dolic uremic toxins derived from ...
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Enzymatic degradation of urinary indoxyl sulfate by Providencia stuartii and Klebsiella pneumoniae causes the purple urine bag syndrome
... We conclude that PUBS results from the action by a bacterial enzyme a phosphatase with minor sulfatase activity, pI 6.4 on the IS in the urine of elderly catheterized patients with high [r] ...
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Uricosuric agents in uremic sera Identification of indoxyl sulfata and hippuric acid
... sera. Indoxyl sulfate, which accumulates to very high concentrations in uremic serum, could not be disclosed in the above-mentioned ...Potassium indoxyl sulfate, when tested in vitro at the ...
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Molecular diversity of heparan sulfate
... Heparan sulfate (HS) appeared early in metazoan evo- lution. As such, many of the structural motifs (variably sulfated disaccharide subunits) that characterize HS (and heparin) were established early on and have ...
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Reductive decomposition of calium sulfate
... In the gaseous reduction of calcium sulfate to pro 5 space surrounding said calcium sulfate, vide calcium oxide substantially free of calcium sul?de, with the sum of said carbon dioxide [r] ...
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A Comparative Investigation of Lead Sulfate and Lead Oxide Sulfate Study of Morphology and Thermal Decomposition
... The morphologic investigations of lead oxide sulfate and lead sulfate that is the goal of this work, were accom- plished by an electron microscope SEM(REM-JEOL- JSM-840). The preparation of the samples ...
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Clinical effectiveness of glucosamine sulfate, chondrotin sulfate, methylsulfonylmethane phonophoresis in knee osteoarthritis
... Glucosamine sulfate, Chondroitin sulfate and Methylsulfonylmethane phonophoresis is superior to topical application for the short term treatment of knee ...
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The Binding of Cations by Chondroitin Sulfate
... In fact, if the activity coeffinow possible to calculate the activity coefficients of the sodium inside the bag, y Na+i, in the presence cients are calculated using the free sodium ion i[r] ...
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FERROUS SULFATE POISONING
... should be aware of the potential danger from ingestion of medication containing irofl. Thompson5’6 found that emesis may rid the stomach of iron tablets even as late as one hour after in[r] ...
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