Induced pluripotent stem cell (iPSCs)
Susceptibility of murine induced pluripotent stem cell-derived cardiomyocytes to hypoxia and nutrient deprivation
... of induced pluripotent stem cells (iPSCs) and improvements in differ- entiation protocols, it is now possible to produce large quantities of patient-specific, autologous CMs (induced ...
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Insulin resistance in diabetes: the promise of using induced pluripotent stem cell technology
... IR. Induced pluripotent stem cell (iPSC) technology offers new tools to study the genetic factors involved in the development of human ...β- cell dysfunction ...
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GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes
... human induced pluripotent stem cell derived cardiomyocytes (iPSC-CM) was first published in 2007 [18] and could be of relevance to this ...
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Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury
... Induced pluripotent stem cells (iPSC) are pluripotent stem cells generated by reprogramming somatic cells ...(induced pluripotent stem cell-derived ...
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The lncRNAs involved in mouse airway allergic inflammation following induced pluripotent stem cell-mesenchymal stem cell treatment
... Fig. 1 Identification of lncRNAs that were differently expressed as expected based on the lncRNA and mRNA microarray results. a Ovalbumin (OVA)-induced allergy was established both in vivo and in vitro. b Long ...
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Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons
... somatic cell reprogramming technology, as well as the development of differentiation protocols for human pluripotent stem cells (PSCs), have jointly engendered new disease models based on ...
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Alzheimer’s in a dish – induced pluripotent stem cell based disease modeling
... Nevertheless, the iPSC approach has several advantages over transdifferentiated cells as it permits obtaining large numbers of cells which can be kept in culture theoretically indefinitely and allows gene-editing at this ...
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Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome
... of induced pluripotent stem cells (iPSCs). Single cell mRNA analyses and immunostaining demonstrated very efficient production of differentiated cells expressing markers of mature neurons of ...
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Lineage- and developmental stage-specific mechanomodulation of induced pluripotent stem cell differentiation
... We first examined how electrospun substrate stiffness af- fected the differentiation of iPSCs to motor neurons (Fig. 2). During the first stage of differentiation towards ectodermal lineage from the pluripotent ...
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Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes
... human induced pluripotent stem cells (iPSCs) and their comprehensive phenotyping is crucial for a better understanding of the subtype-related disease mechanisms and as tools for the development of ...
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Perspectives on the Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Biomedical Research
... generate induced pluripotent stem cells (iPSCs) by reprogramming somatic tissues is arguably the greatest breakthrough in biomedical science of the last ...embryonic stem cells ...generating ...
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Genetic background affects induced pluripotent stem cell generation
... The cell pellet was then washed, resuspended in unconjugated primary antibody for 1 hour at 4°C, washed, and resuspended in a secondary fluorescent-con- jugated antibody for an additional 1 hour at ...
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Baboon induced pluripotent stem cell generation by piggyBac transposition of reprogramming factors
... Figure 3. biPSC characterization by RT-PCR. (a) Expression anal- ysis of the five baboon iPSCs lines (DPZ_biPSC1-5). In the absence of a baboon ESC line, rhesus embryonic stem cells (rhESC) were used as a positive ...
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Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening
... Pluripotent stem cells have also been explored as a promising cell source for cardiac cell ...as cell immunogen- icity, survival, and electrophysiological integration, remain to be ...
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A safeguard system for induced pluripotent stem cell-derived rejuvenated T cell therapy
... Human induced pluripotent stem cells (iPSCs) can unlimit- edly self-renew and differentiate into various cell types (Ta- kahashi et ...undifferentiated pluripotent cells with chemical ...
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Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes
... The discovery of hPSC-CMs, including hPSC-CMs and hESC-CMs, has been an attractive in vitro model to study cardiotoxicity. Many researchers have used hiPSC- CMs and hESC-CMs as screening models for pro- arrhythmic ...
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Transplantation of induced pluripotent stem cell-derived renal stem cells improved acute kidney injury
... embryonic stem cells (ESCs) and adult stem cells, have the potential of self-renewal and differentiation into multiple cell types and therefore hold great promise in regenerative medicine ...that ...
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Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming
... (UCSF cell culture facility, catalog num- ber CCLZR211, log number MB3145, passages 9–20) was performed using the Neon Transfection system as de- scribed previously ...iPS cell media as described previously ...
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Induced pluripotent stem cell–derived cardiomyocytes in studies of inherited arrhythmias
... both cell types presented features of immature cells: large glycogen deposits, lipid droplets, large endoplasmic reticulum, rough endoplasmic reticulum, and an immature sar- coplasmic reticulum ...of cell ...
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The effect of magnetic nanoparticles on neuronal differentiation of induced pluripotent stem cell-derived neural precursors
... Suspensions of iPSC-NPs labeled with different concen- trations (5, 10 and 15 μ g Fe/mL of cultured media) with two types of nanoparticles (CZF and PLL-coated γ -Fe 2 O 3 ) for 72 hours were washed three times with PBS ...
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