Induced Pluripotent Stem Cells (iPSCs)
Generation of induced pluripotent stem cells from large domestic animals
... iPSCs: Induced pluripotent stem cells; OSKM: Oct4, Sox2, KFL4, and c-Myc; biPSCs: Bovine induced pluripotent stem cells; miPSCs: Mouse induced ...
12
Induced Pluripotent Stem Cells: History, Properties and Potential Applications
... of induced pluripotent stem cells (iPSCs) has been met with much enthusiasm and hailed as a breakthrough discovery by the scientific and research communities amidst the divisive and ongoing ...
6
Induced pluripotent stem cells in infections
... myeloid cells (eosinophils, important effector cells releasing cytotoxic mediators such as ECP, EDN, MBP, EPO), and role of iPSCs as cell-based therapy in various immune deficient ...of induced ...
5
Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells
... their pluripotent characteristics, human induced pluripotent stem cells (iPSCs) possess great potential for therapeutic application and for the study of degenerative ...These ...
9
Induced pluripotent stem cells in medicine and biology
... In 2007, the proof of concept of the therapeutic use of iPSCs was reported for the mouse model of sickle-cell anemia, a genetic blood disorder caused by a defect in the β-globin gene (Hanna et al., 2007). Gene correction ...
5
Biomedical Applications of Induced Pluripotent Stem Cells
... iPS cells from a child afflicted with a genetic spinal muscular ...These cells were able to maintain the disease genotype, and capable of differentiating into motor neurons that revealed specific defects in ...
12
Induced pluripotent stem cells: An update
... The efficiency of induction is increased by many additional genes which have been identified as members of the Klf family such as Klf1, Klf2, Klf4, and Klf5; the Myc family such as c-myc, L-myc, and N-myc; Nanog, and ...
8
Understanding Megakaryopoiesis And Thrombopoiesis Using Human Stem Cells Models
... Human stem cell models (CD34+ hematopoietic progenitors, embryonic stem cells and induced pluripotent stem cells (iPSCs)) are powerful tools for the study of ...
123
Modeling of Sic Power Semiconductor Devices For Switching Converter Applications
... human induced pluripotent stem cells were differentiated into endothelial cells and then injected into immunodeficient mice with ischemic ...positive cells and transplanted them ...
151
Mouse induced pluripotent stem cells
... iPS cells in human therapeutics is the risk posed by retroviral transduction of the three/four transcription ...modify cells is to introduce genes by retroviral integration thereby potentially causing ...
9
Induced pluripotent stem cells: advances to applications
... way, stem cell-based regenerative medicine is expected to drive the evolution of medical sciences from palliation, which mitigates symptoms, to curative therapy aimed at treating the root cause of degenerative and ...
9
Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury
... multipotent cells that are able to proliferate, self- renew, and differentiate into various somatic cells in vitro, and they have attracted much attention for re- storing tissue function in vivo with little ...
12
A SY Stematic approach towards understanding stem cell biology
... various stem cell research ...how stem cells make ‘ decisions ’ during early development and how stem cells function in the ...embryonic stem cells (ESCs), induced ...
6
Stem Cell Sources for Regenerative Medicine and Cartilage Tissue Engineering.
... Stem cells have been studied widely as a potential resource for regenerative medicine as they can proliferate for long-term while maintaining differentiation ...of cells and tissues within body. ...
85
DeepNEU: cellular reprogramming comes of age – a machine learning platform with application to rare diseases research
... expressed pluripotent transcription factors and the efficiency of inducting protocols for PSCs [18, ...somatic cells is very ...artificially-induced pluripotent stem cells ...
13
Directly induced human Schwann cell precursors as a valuable source of Schwann cells
... Human pluripotent [embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)] [4, 5] and multi- potent stem cells from adipose [6, 7], bone ...
12
Ex Vivo Gene Therapy for Lysosomal Storage Disease Using Ipsc-Derived Neural Stem Cells
... Induced pluripotent stem cells are promising candidates for treating many diseases in the ...patient cells because of the cross-correction ...deficient cells (Fratantoni et ...
101
Pluripotency of induced pluripotent stem cells
... fully pluripotent iPS cells, numerous iPS cell lines underwent tetraploid complementation assays, and live pups were finally generated in three inde- pendent laboratories including our own ...iPS ...
7
Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells
... beating cells in- creased in a histamine dose-dependent manner and reached a peak at the concentration of 10 μM ...differentiation induced by histamine was further confirmed by immunofluor- escence ...
20
Therapeutic use of stem cells for cardiovascular disease
... embryonic stem cells as well as a lim- ited supply of donor human ...of induced pluripotent stem cells ...embryonic cells [6, ...
8