infected macrophages
TREM 1 Protects HIV 1 Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function
... ABSTRACT Macrophages are a reservoir for latent human immunodeficiency type 1 (HIV) infection and a barrier to HIV ...tion, macrophages increase the expression of BCL2, BCLXL, TREM1, mitofusin 1 (MFN1), and ...
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Autophagy favors Brucella melitensis survival in infected macrophages
... For some pathogens, such as Mycobacterium tuberculosis [21], and Shigella [22], autophagy is an important host defense mechanism in the elimination of intracellular bacteria and protozoans, indicating that this pathway ...
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Human immunodeficiency virus infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains
... HIV-infected macrophages (SI), uninfected macrophages (SU), infected T cells, or macrophage-conditioned media from four AIDS ...of macrophages found to be expressing HIV ...uninfected ...
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Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages
... As we had previously shown that EVs activate DCs (21), we next turned our attention to EVs and showed that they were responsible for the first phase of ISG induction. We showed that an HIV stock containing EVs induced ...
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Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages
... Total BMM RNA was obtained from Mtb-infected cells at 6 and 24 hpi using the Trizol method as mentioned previously [18]. Briefly, BMM were lysed with Trizol reagent (Invitrogen, Carlsbad, CA) and total RNA was ...
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Cytotoxic activity against maedi-visna virus-infected macrophages.
... When skin-cell-activated CTL were used, depletion of CD8+ effector cells reduced the lysis of MVV-infected skin cell targets to background levels; however, there was apparently still som[r] ...
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Identification of Human Herpesvirus 6 Latency-Associated Transcripts
... HHV-6-infected macrophages. RNA from serially diluted HHV-6 latently infected macrophages was amplified by double-nested RT-PCR with primers LEF2 and IE5RD and LEF1 and ...
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Coordinate Regulation of DNA Damage and Type I Interferon Responses Imposes an Antiviral State That Attenuates Mouse Gammaherpesvirus Type 68 Replication in Primary Macrophages
... mock-infected macrophages at 28 h postinfection was associated with accumulation of all three ISG mRNA at 8 h posttreatment ...in macrophages infected with wt MHV68 ...irradiated ...
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Deletion of a Single LeishIF4E-3 Allele by the CRISPR-Cas9 System Alters Cell Morphology and Infectivity of Leishmania
... 264.7 macrophages at a ratio of 10:1 for 1 h. The macrophages were washed three times with PBS and once in DMEM to remove extracellular ...The infected macrophages were incubated for 24 h at ...
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Dual Transcriptome Profiling of Leishmania Infected Human Macrophages Reveals Distinct Reprogramming Signatures
... for macrophages; similar samples clustered together by infection status per time ...control macrophages showed notable vari- ance, denoting a drift in the transcriptome as the cells were main- tained in ...
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Oxidative stress fuels Trypanosoma cruzi infection in mice
... Oxidative damage contributes to microbe elimination during macrophage respiratory burst. Nuclear factor, erythroid-derived 2, like 2 (NRF2) orchestrates antioxidant defenses, including the expression of heme-oxyge- ...
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Macrophage Apoptosis in Tuberculosis
... Before discussing apoptosis of Mtb-infected macrophages it may be helpful to briefly review the major pathways and modes of programmed cell death. Caspases belong to a family of cysteine proteases whose ...
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Transient Down-Regulation of Nucleoside Transporter 3 Gene Expression as a Drug Target in Leishmania major Using Antisense RNA Technology
... amastigotes infected macrophages with trans- genic ...than infected macrophages with wild-type ...mice infected with transgenic Leishmania promastigotes were less than the BALB/c mice ...
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Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes
... animals infected by Kim5 ...of infected cells allows for the unrestricted release of intracel- lular bacteria into the extracellular space, promoting expedient infection of neighboring cells (Supplemental ...
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Brain Macrophages in Simian Immunodeficiency Virus Infected, Antiretroviral Suppressed Macaques: a Functional Latent Reservoir
... whether macrophages also fit the definition of a latent ...latently infected macrophages or whether macrophages will require different strategies for ...latently infected rCD4 in ...
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Transcriptomic Signature of Leishmania Infected Mice Macrophages: A Metabolic Point of View
... We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at different times after infection with promastigotes of the protozoan parasite Leishmania major. Ingenuity Pathway Analysis ...
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EVALUATION OF THE IMMUNOMODULATORY EFFECT OF PIPLARTINE AND ITS DERIVATIVE ON PERITONEAL MACROPHAGES OF SWISS MICE INFECTED WITH LEISHMANIA AMAZONENSIS
... the infected macrophages, indicating that they acted as modulators of the immune response in ...the macrophages were infected and treated with different concentrations of piplartine (A), there ...
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Synthesis, Characterization and Analysis of Leishmanicide Ability of the Compound [Ru(Cl)3(H2O)2(gly)]
... of infected macrophages adhered to the glass coverslips treated with (50 µg /mL to 400 µg/mL) and stained with Giemsa, was obtained by counting by optical ...of infected macrophages in ...
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Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light
... the macrophages were incubated overnight in RPMI-1640 ...Adherent macrophages were infected with ...of infected macrophages and the average number of parasites per macrophage was ...
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Luteolin, an Abundant Dietary Component is a Potent Anti-leishmanial Agent that Acts by Inducing Topoisomerase II-mediated Kinetoplast DNA Cleavage Leading to Apoptosis
... In the present study, we tested anti- leishmanial activity of five naturally occurring flavonoids: luteolin, quercetin, rutin, 5-hydroxy 3,6,7,3’,4’ pentamethoxy flavone (flavone A), and isoorientin (Fig. 1). Of these ...
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