Infected Mice
Challenge of Chronically Infected Mice with Homologous Trypanosoma cruzi Parasites Enhances the Immune Response but Does Not Modify Cardiopathy: Implications for the Design of a Therapeutic Vaccine
... Chagas disease is a Trypanosoma cruzi-induced zoonosis that has no natural cure. Local damage induced by the parasite and the immune response causes chronic heart and digestive lesions. Efforts to develop a therapeutic ...
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Improved methods for haemozoin quantification in tissues yield organ and parasite specific information in malaria infected mice
... malaria-infected mice. Most Hz was detected in kidneys and hearts from PbNK65-infected mice ten days post-infection compared with PbANKA and PcAS-infected mice seven to eight and ...
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Successful integration of transplanted mesenchymal stem cells into the livers of Schistosoma mansoni infected mice
... One of the most serious consequences of Schistosoma (S.) mansoni infection is hepatic schistosomiasis or periportal fibrosis. Treatment with praziquantel (PZQ) remains the mainstay of schistosomiasis control. Stem cells ...
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Effect Of Curcumin On Hematological, Biochemical And Antioxidants Parameters In Schistosoma Mansoni Infected Mice
... 4). Infected non treated mice showed significant increases of AFP and TNF-a compared with control ...to infected mice improved the both AFP and TNF- α levels as compared to infected ...
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Comparison of PCR and culture to the indirect fluorescent antibody test for diagnosis of Potomac horse fever
... presently infected or has been exposed to ehrlichial antigens in the ...experimentally infected with ...from mice inocu- lated with ...subclinically infected mice by the nested ...
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Vesicular Stomatitis Viruses with Rearranged Genomes Have Altered Invasiveness and Neuropathogenesis in Mice
... Transcription of vesicular stomatitis virus is controlled by the position of a gene relative to the single 3 ⴕ genomic promoter: promoter-proximal genes are transcribed at higher levels than those in more 5 ⴕ distal ...
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Gradual Elimination of Retroviruses in YBR/Ei Mice
... Semiquantitative PCR and footpad injection. High-molecular-weight DNA was isolated from spleens of MMTV(C3H)-infected mice at 8 weeks of age and was resuspended at 0.1 mg/ml. Both endogenous and exogenous ...
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Prolonged Gray Matter Disease without Demyelination Caused by Theiler's Murine Encephalomyelitis Virus with a Mutation in VP2 Puff B
... of mice developed polioen- cephalomyelitis, and lesions were mainly found in the gray matter of the brain (Table ...virus-infected mice, we could see MNC infiltrates in perivascular spaces and in the ...
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Emergence of a Large Plaque Variant in Mice Infected with Coxsackievirus B3
... in mice infected with N63Y mutant CVB3 compared with uninfected ...the mice infected with WT CVB3 had higher ALT levels than un- infected mice, 66% of the mice ...
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Defective interfering influenza virus inhibits immunopathological effects of infectious virus in the mouse.
... Lungs taken from infected mice showed an increase in cellular infiltration of nearly threefold at 5 days p.i., but infected mice protected by DI virus contained about half the number of [r] ...
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Regulatory Role of CD1d in Neurotropic Virus Infection
... We infected wild-type and CD1 ⫺/⫺ mice with DA virus of the TO subgroup of TMEV and observed the mice for clinical ...and infected mice recovered during the following 1 ...⫺/⫺ ...
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Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice
... In contrast to the gene expression results, the level of mature PCSK9 protein in the liver was unchanged in the P. gingivalis-infected mice compared to the sham- infected mice, whereas the ...
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Inhibition of ER Stress by 2-Aminopurine Treatment Modulates Cardiomyopathy in a Murine Chronic Chagas Disease Model
... demonstrated a significant increase in the cardiac mRNA levels of collagen I and III in the infected mice 145... 7 compared to uninfected mice.[r] ...
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Failure To Open the Blood-Brain Barrier and Deliver Immune Effectors to Central Nervous System Tissues Leads to the Lethal Outcome of Silver-Haired Bat Rabies Virus Infection
... of infected CNS tissues by immune effector cells from the circulation is dependent upon a sequence of events that includes the production of proinflammatory cyto- kines and chemokines by CNS-resident ...paralyzed ...
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Lymphocyte and Antibody Responses Reduce Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads
... of infected mice by decreasing viral loads in ...C57BL/6 mice and their congenic mice deficient in B, CD4 T, or CD8 T cells after inoculation with ...EV71. Infected lympho- ...
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T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions.
... of mice with lymphocytic choriomeningitis virus (LCMV) causes a major expansion of CD8 1 T cells followed by a period of immune downregulation that coincides with the induction of lymphocyte apoptosis in the mouse ...
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Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion
... of infected DCs to stimulate the proliferation of T cells, we investigated whether splenocytes from virus-infected mice could induce the proliferation of T cells in a primary allogeneic ...from ...
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Lethal Monkeypox Virus Infection of CAST/EiJ Mice Is Associated with a Deficient Gamma Interferon Response
... of infected mice. We previously reported that CAST/EiJ mice can make ro- bust antibody and cytotoxic T cell responses upon nonlethal in- fection with vaccinia virus (VACV) and that this immune re- ...
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Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model
... in infected humanized ...of mice infected with SIVcpzPtt MB897 (n ⫽ 3), SIVcpzPtt EK505 (n ⫽ 2), and SIVcpzPtt MT145 (n ⫽ 2) at 15 wpi was ...of infected mice at 15 wpi, and cDNA was ...
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Enterovirus A71 Infection Activates Human Immune Responses and Induces Pathological Changes in Humanized Mice
... humanized mice did not succumb to EV-A71 infection, with 100% survival and no observable clinical ...humanized mice showed different suscep- tibilities to EV-A71 infection, with 3-week-old humanized ...
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