inhibitory antibodies
A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens
... human inhibitory antibodies we observed is consistent with the strain-specific efficacy reported in a phase II AMA1 vac- cine trial ...the inhibitory activity of antibodies to different ...of ...
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Generation of Plasmodium falciparum parasite inhibitory antibodies by immunization with recombinantly expressed CyRPA
... invasion-inhibitory antibodies that are effective across common PfRH5 genetic variants and PfRH5-based vac- cines can protect Aotus monkeys against virulent vac- cine-heterologous ...invasion ...
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Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies
... acquired antibodies for inhibition of parasite lines with defined invasion phenotypes and ligand expres- ...the inhibitory activity of acquired antibodies is influenced by variation in invasion ...
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Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high titer inhibitory antibodies
... While gene therapy for hemophilia A has been attempted in humans, therapeutic levels of FVIII have not yet been achieved (7, 17). This failure may be attributed in part to the fact that none of these approaches directed ...
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Development and Optimization of High Throughput Methods To Measure Plasmodium falciparum Specific Growth Inhibitory Antibodies
... measuring antibodies to re- combinant merozoite antigens by enzyme immunoassays has been widely applied in population studies, this approach has significant limitations and does not appear to be sufficiently ...
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HIV-1 Replication in Langerhans and Interstitial Dendritic Cells Is Inhibited by Neutralizing and Fc-Mediated Inhibitory Antibodies
... The inhibitory activity of HIV-1-specific IgAs and IgGs against HIV-1 replication in LCs and IDCs was ...neutralizing antibodies inhibit HIV-1 infection of both DC ...nonneutralizing inhibitory IgGs ...
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Identification of VAR2CSA Domain-Specific Inhibitory Antibodies of the Plasmodium falciparum Erythrocyte Membrane Protein 1 Using a Novel Flow Cytometry Assay
... rabbit antibodies or purified pooled multigravida IgG antibodies (10 women from Muheza, Tanzania) in blocking ...above, antibodies were visualized using the 5-bromo- ...
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Inhibitory Antibodies Targeting Emerging Viruses: Advancements and Mechanisms
... of antibodies is to neutralize virus entry, and analysis of that mech- anism traditionally serves as the criterion for antiviral antibody ...as antibodies targeting specific pathogenic functions, such as ...
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Role of Tumour Necrosis Factor (TNF) and Glycosylphosphatidylinositol (GPI) as Important Mediators in the Pathogenesis of Malaria Infection
... invasion-inhibitory antibodies specific for the 19KDa fragment of merozoite surface protein-1 (MSP-1 19 ) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a ...
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Hemophilia A gene therapy via intraosseous delivery of factor VIII-lentiviral vectors
... develop inhibitory antibodies to FVIII following re- peated infusions of ...without inhibitory anti- ...of antibodies against the products themselves still need to be evaluated over ...
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Activated Human CD4+CD45RO+ Memory T-Cells Indirectly Inhibit NLRP3 Inflammasome Activation through Downregulation of P2X7R Signalling
... blocking antibodies specific for the identified candidates or purified ...the inhibitory effect of IFNb-treated memory T-cells on IL-1b release, as addition of FasL blocking antibodies diminished the ...
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Cellular responses to modified Plasmodium falciparum MSP119 antigens in individuals previously exposed to natural malaria infection
... blocking antibodies, which have overlapping spe- cificities and compete with inhibitory antibodies for bind- ing to the antigen, thereby allowing processing and invasion to occur even in the presence ...
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Presence of antibodies against cyclic citrullinated peptides in patients with 'rhupus': a cross sectional study
... We included all patients fulfilling American College of Rheu- matology (ACR) classification criteria for both RA [9] and SLE [10] who belonged to our cohorts of patients with RA and with SLE. Comparisons were made with ...
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Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis
... with 1 ml of DMEM and used in the experiments. After incu- bation for various periods of time, the medium was collected and concentrated 20-fold using spin filters (Microcon YM-30; Merck Millipore), and 20 ml of 43 SDS ...
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Functional Analysis of Antibodies against Dengue Virus Type 4 Reveals Strain-Dependent Epitope Exposure That Impacts Neutralization and Protection
... Amino acid mapping of epitopes by shotgun mutagenesis and ex- pression in mammalian cells. A DENV-4 prM-E protein expression con- struct (strain TVP-376) was subjected to high-throughput alanine-scan- ning mutagenesis to ...
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GC MS ANALYSIS AND INVITRO ENZYME INHIBITORY EFFECT OF DIFFERENT SOLVENT EXTRACTS OF GARCINIA CAMBOGIA FRUIT
... 2005). The standard drug orlistat is the most active compound in inhibiting gastric, pancreatic and carboxyl ester lipase and has been proved to be effective for the human obesity treatment (Scarpace et al., 2002; ...
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Double seronegative myasthenia gravis with antiphospholipid syndrome: a case report
... We have reported a case of MG in which an APS was di- agnosed a few years before. The patient tested negative for both AChR-Ab and MuSK-Ab, which is a very rare situation. Recently published data have shown that ...
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IFN λ1 with Th17 axis cytokines and IFN α define different subsets in systemic lupus erythematosus (SLE)
... Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. One hallmark of SLE is the pres- ence of autoantibodies against nuclear constituents (antinuclear antibodies [ANA]), including anti-double- ...
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Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission
... neutralizing antibodies or inhib- itors have been few ...tralizing antibodies against cell-free HIV, SIV, and SHIV trans- mission ...neutralizing antibodies against HIV-1, TZM-bl cells are not ...
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Intravenous immunoglobulin contains specific antibodies inhibitory to activation of T cells by staphylococcal toxin superantigens [see comment]
... In the present study the ability of pooled IgG to inhibit Staph-toxin elicited T cell activation was not mediated nonspecifically through the Fc region of IgG, as shown by the lack of in[r] ...
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