innate immune-responses
Viral Induction of Central Nervous System Innate Immune Responses
... these immune mediators, as leukocyte infiltration did not reach a peak until days 5 and 8 after ...the innate immune response (presumably induced by resident brain cells) contributes to disease ...
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Regulation of autoreactive B cells during innate immune responses
... experienced B cells. We recently identified a tolerance mechanism that selectively represses Ig secretion by autoreactive B cells during innate immune responses. We find that chronically ...
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Innate Immune Responses of Bat and Human Cells to Filoviruses: Commonalities and Distinctions
... of innate immune responses to filoviruses and the role of filovirus IID in bat and human ...potent innate immune response in rousette cells, which was gen- erally stronger than that in ...
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Measuring some flounder (Platichthys flesus L.) innate immune responses to be incorporated in effect biomonitoring concepts
... In an attempt to incorporate measurements of innate immune responses in an integrated biological effect monitoring concept in flounder (Platichthys flesus L.), leucocytes were isolated from ...
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Innate immune responses in hepatitis B virus (HBV) infection
... of innate immunity in the early stages of viral infections in general has led to a re-evaluation of the innate immune system in HBV ...evade innate immune responses and induce ...
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HIV 1 Is a Poor Inducer of Innate Immune Responses
... of innate immune markers; they showed neither type I IFN production nor ISG mRNA induction nor STAT1 phosphorylation for up to 3 days after ...IFN responses in a mitochondrial antiviral signaling ...
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Junín Virus Infects Mouse Cells and Induces Innate Immune Responses
... Junín virus is the causative agent for Argentine hemorrhagic fever, and its natural host is the New World rodent Calomys musculinus. The virus is transmitted to humans by aerosolization, and it is believed that many of ...
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RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses
... It has been reported that autophagy plays a critical role in regulating cGAS activation [19]. Post-translational modifications have also been shown to be important for cGAS regulation. For instance, Akt (also known as ...
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Toll like receptors and innate immune responses in systemic lupus erythematosus
... High mobility group box protein release from necrotic cells and stimulation of Toll-like receptor 9 by DNA HMGB proteins provide a new paradigm for how cell death may be linked to innate immune ...
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Modulation of T cell and innate immune responses by retinoic Acid
... Th17 responses are constrained during vitamin A deficiency and in nuclear RA receptor a–defective ...cell responses during infection or autoimmune ...in immune homeostasis in the steady-state but ...
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CD8 T Cells in Innate Immune Responses: Using STAT4 Dependent but Antigen Independent Pathways to Gamma Interferon during Viral Infection
... between innate cytokine and antigen stimulation in acutely responding and resulting memory CD8 T ...in immune mice maintained elevated STAT4, responded to IFN- ␣ with pSTAT4 induction in vivo, and had ...
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HIF-mediated innate immune responses: cell signaling and therapeutic implications
... conditions. Immune cells are an important feature of these conditions, as are the tissue cells, and their relative and context-specific expression of the HIF pathway components may modify clinical ...
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Identification of Respiratory Syncytial Virus Nonstructural Protein 2 Residues Essential for Exploitation of the Host Ubiquitin System and Inhibition of Innate Immune Responses
... Replication of the NS2 mutant rRSV was attenuated in IFN- sufficient A549 cells even at early time points postinfection, which can be explained by the loss of STAT2 proteasomal targeting re- sulting in heightened ...
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Inhibition of Innate Immune Responses Is Key to Pathogenesis by Arenaviruses
... A newly suggested taxonomy divides the Arenaviridae family into the genera Mammarenavirus and Reptarenavirus, whose res- ervoirs are mainly rodents and reptiles (i.e., snakes), respectively (3). Mammalian arenaviruses ...
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Activation of Innate Immune Responses by Haemophilus influenzae Lipooligosaccharide
... effect than the wild type on the surface molecules ICAM-1, CD40, and CD58 and proinflammatory cytokines TNF-␣ and IL-1. The main compositional differences between Rd lic1 lpsA and Rd are the deletions of ...
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Search | Preprints
... these immune responses. Escape from adaptive immune responses may be achieved by the emergence of viral escape mutations that avoid recognition by antibodies and T cells ...of innate ...
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Innate, adaptive and regulatory immune responses in human schistosomiasis in Gabon
... TLR responses in other helminth infections than schistosomiasis have been published and show varying ...cytokine responses upon TLR stimulation of PBMCs in a population from the same area with latent ...
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Dendritic cell and macrophage-mediated tolerance in lupus-prone mice
... encounter M s and B cells. Marginal zone (MZ) B cells in the spleen and B1 B cells in the peritoneal cavity are primed for a quick response to bacterial and viral antigens to fight infection as a first line of defense ...
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The role of leptin in innate and adaptive immune responses
... A potential role of leptin has been recently investigated in several models of arthritis depending on acquired or innate immune responses. Antigen-induced arthritis (AIA) is an experimental model of ...
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Hypoxia Hypoxia, hypoxia inducible factor and myeloid cell function
... transcriptional responses to relative physiological oxygen tensions is now well described, with the oxygen-sensitive hydroxylase enzymes critical in this ...regulating innate immune ...inflammatory ...
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