iNOs activity
Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in established murine cancer model
... in iNOS-KO mice treated with GalCer (Figure ...tumor-bearing iNOS-mice treated with ...in iNOS-KO mice treated with GalCer was lower than that in WT mice treated with GalCer (Figures 3A and ...that ...
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The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes
... and activity in microglial cultures activated by pro- inflammatory cytokines while displaying minor effects on astrocyte iNOS [21], thus suggesting that mTOR reg- ulates glial inflammatory activation but ...
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Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T gondii infection
... of iNOS in the macrophages of mouse strains and, vice versa, lower expression of Arg 1 was accompanied by higher expression of iNOS in the rat peritoneal ...Arginase activity in the peritoneal ...
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Abstract
... that iNOS expression in peripheral blood leukocytes was higher in pa− tients with arthritis than in healthy ...higher iNOS activity and ele− vated NO (nitric oxide) concentrations in synovial fluid ...
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Autoregulation of pro-inflammatory protein expression in murine macrophages by nitric oxide
... that INOS relies on extracellular supplies of L-arginine and that activation of macrophages with LPS leads to an increased up-take of L-arginine (Bogle et al, ...to iNOS (Closs et a l, ...for iNOS ...
210
Еndothelial dysfunction due to sodium nitrite
... In the report of the World Health Organization from 1990 to 2016 to this day, Ukraine continues to occupy first place in the European region in morbidity and mortality from diseases of the cardiovascular system. One of ...
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Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells
... (iNOS) activity has been demonstrated in a wide array of cells and tissues [3, ...of iNOS, has diverse and important roles in host defense against a variety of pathogens [5, 6], neurotransmission, ...
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<p>iNOS is associated with tumorigenicity as an independent prognosticator in human intrahepatic cholangiocarcinoma</p>
... of iNOS in chronic in fl ammation can produce ROS and RNS, causing DNA damage, which leads to the development and progression of ...Increased iNOS activity has been positively correlated with the ...
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Modulation of Mitogen-Response and Phagocytic Activities of Human Lymphocytes and Macrophages by Aqueous, Hexane and Methanol Extracts of Stem Bark of Boswellia Dalzeilii, Hutch (Family: Burseraceae).
... bactericidal activity of the phagocytes and metabolic activity of granulocytes or monocytes 20 ...of iNOS that oxidizes L-arginine to citrulline and nitric oxide. The iNOS activity is ...
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Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death
... few iNOS-overexpressing mice (<8%) developed overt heart failure with depressed cardiac hemodynamic function, gross structural cardiomyocyte damage, and significant increases in interstitial collagen, ...
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Inducible nitric oxide synthase expression in gastric adenocarcinoma: impact on lymphangiogenesis and lymphatic metastasis
... that iNOS may be expressed by different cellular components in tumor tissues; indeed, iNOS expressed by tumor cells may play an important role in the pathogenesis and progression of gastric ...the ...
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Effects of chitosan on nitric oxide production and inducible nitric oxide synthase activity and mRNA expression in weaned piglets
... duced iNOS gene expression and improved the activity of iNOS and NO ...of iNOS activity in the serum and iNOS mRNA expression in the small intestine of piglet by ...
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Reversal of impaired wound repair in iNOS deficient mice by topical adenoviral mediated iNOS gene transfer
... reduced iNOS expression and reduced NO availability, such as steroid administration and diabetes (12, ...of iNOS or continuous iNOS inhibition leads to a similar delay in closure rates in mice, ...
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Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock
... selective iNOS inhibitors or transgenic mice deficient in iNOS had less hypotension and preserved microvascular reactivity under septic con- ditions ...Furthermore, iNOS inhibition stabilized also ...
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Autocrine inhibition of Na+/K(+) ATPase by nitric oxide in mouse proximal tubule epithelial cells
... in activity). The inhibition of Na+/K(+)-ATPase activity by LPS/IFN gamma was prevented by simultaneous incubation with N omega-nitro L-arginine and markedly blunted by removal of L-arginine from the ...
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Tumor associated macrophages polarization dictates the efficacy of BCG instillation in non-muscle invasive urothelial bladder cancer
... grade disease [3-5]. Mycobacterium bovis (Bacillus Calmette Guerin – BCG) has been established as the most effective adjuvant treatment for decreasing recurrence and tumor progression risk. Since its first use in 1976 ...
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Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-κB and JNK/p38 MAPK activation pathways
... Aciculatin was extracted and purified by one of our col- leagues (Dr. Chien-Chih Chen) to a purity of greater than 98% by HPLC and NMR. Its structure is shown in Figure 1. Mouse monoclonal antibodies against iNOS ...
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Inducible nitric oxide synthase is critical for immune mediated liver injury in mice
... potent oxidant (13). Peroxynitrite and other reactive nitrogen species react with free or protein-bound tyrosine residues to form 3-nitrotyrosine, a suitable marker for NO-mediated tissue damage (13, 14). At least three ...
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Herbal formula SC E1 suppresses lipopolysaccharide stimulated inflammatory responses through activation of Nrf2/HO 1 signaling pathway in RAW 264 7 macrophages
... as iNOS (sc-650), COX-2 (sc-376861), HO-1 (sc-10789), Nrf2 (sc-722), p-IκB (#9246), IκB (#9242), p-NF-κB (#3037), Lamin B (sc-374015), β-actin (sc-47778), p- ERK1/2 (sc-7383), p-JNK (#9251), p-p38 MAPK (#9211), ...
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Ghrelin Suppression of Helicobacter pylori Induced Gastric Mucosal Expression of iNOS is Mediated through the Inhibition of IKK β Activation by cNOS Dependent S Nitrosylation
... Cell-wall lipopolysaccharide (LPS) of H. pylori, a Gram- negative bacterium colonizing the gastric mucosa of over 50% of the human population, is recognized as a potent endotoxin capable of eliciting mucosal inflammatory ...
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