insulin analogues
Differences in bioactivity between human insulin and insulin analogues approved for therapeutic use- compilation of reports from the past 20 years
... first insulin derivatives were synthetised in the 1970s for scientific purposes [1,2], the therapeutic poten- tial of these compounds for diabetic patients was already under ...the insulin derivative B10Asp ...
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Insulin analogues dosing and costs - comparing real-life daily doses of insulin detemir and insulin glargine in type 2 diabetes patients
... daily insulin dose. Nei- ther concomitant insulin use nor use of non-insulin anti- diabetic medication was ...concomitant insulin use and use of non- insulin anti-diabetic medication ...
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Short-acting insulin analogues versus regular human insulin on postprandial glucose and hypoglycemia in type 1 diabetes mellitus: a systematic review and meta-analysis
... short-acting insulin analogues vs regular human insulin on hypoglycemia and postprandial glucose levels in patients with ...short-acting insulin analogues vs. regular human ...
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Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake
... Adams, JP and Holder, AL and Catchpole, B (2014) Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake.. This manu[r] ...
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Alternative signaling network activation through different insulin receptor family members caused by pro mitogenic antidiabetic insulin analogues in human mammary epithelial cells
... these insulin analogues have an increased mitogenic ...the insulin ana- logues could act either as a tumor initiator by trans- forming benign or (pre)neoplastic cells, which often express increased ...
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Results of glycated hemoglobin during treatment with insulin analogues dispensed in the public health system of Federal District in Brazil
... glargine insulin and NPH insulins” ...of insulin analogue delivery and not NPH; another study had only 4 month duration; and hypoglycemia reduction, a gold- standard outcomes of insulin ...
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Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta analysis of in vitro, animal and human evidence
... upon insulin ex- posure may differ for different breast cancer ...and insulin (analogues) exposure among dia- betic patients with breast cancer [49, ...DM, insulin treatment is associated with ...
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Current european regulatory perspectives on insulin analogues
... Insulin analogues are increasingly considered as an alternative to human insulin in the therapy of diabetes ...mellitus. Insulin analogues (IAs) are chemically different from human ...
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Characterisation of insulin analogues therapeutically available to patients
... 1. Insulin forms complex oligomeric structures including, but not limited to, dimers and ...stable. Insulin analogues, specifically the fast-acting insulins, have been designed to prefer the ...
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A prospective randomised cross-over study of the effect of insulin analogues and human insulin on the frequency of severe hypoglycaemia in patients with type 1 diabetes and recurrent hypoglycaemia (the HypoAna trial): study rationale and design
... Insulin analogues were developed to improve treat- ment of insulin-treated diabetes with respect to glycae- mic control and avoidance of hypoglycaemic ...Short-acting insulin analogues ...
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Conformational flexibility of the pharmacologically important insulin analogues
... of insulin formulations for injection ...of insulin: bolus (needed after meals) and basal (supplies the basal level of insulin for the day) ...of insulin analogues have been developed: ...
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Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/+WAPCre mouse model
... of insulin analogues are limited. The binding affinity of insulin analogues to both IR and IGF1R and their subsequent activation and overall mitogenic capacity are currently used as part of ...
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An Overview on the Insulin Preparations and Devices
... the insulin amount (up to 300 units) to release in periodic ...the insulin delivery. The most suitable site for continuous insulin infusion is the abdomen, although other regions like thigh is also ...
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Uptake of new antidiabetic medications in three emerging markets: a comparison between Brazil, China and Thailand
... were insulin analogues. We found that insulin analogues accounted for over a quarter of the market share in Brazil, China, and ...lin analogues accounted for about two-thirds of the ...
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Cell factories for insulin production
... (insulin, insulin analogues, non-glycosylated human growth hormone somatotropin, glucagon), vac- cines (hepatitis B virus surface antigen), uprate oxidase from Aspergillus flavus, ...
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Needle-free insulin drug delivery
... deliver insulin. In the last two decades, concept of insulin therapy by multiple-dose injection has undergone a miraculous ...Needle-free insulin delivery appeared to be a wonderful approach, and its ...
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Hexasulfanyl analogues of cyclotriveratrylene
... Cyclotriveratrylene (2,3,7,8,12,13-hexamethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononene, CTV; Scheme 1) is a rigid bowl-shaped molecule that is an important synthon in supramolecular chemistry. 1-3 CTV itself can ...
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Synthesis of nucleoside analogues
... relationships and may be expected to assume the same conformations as their nucleoside analogues. Thus the carbocyclic derivatives have the potential either to mimic or antagonize the functions of the naturally ...
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Fluorescent Cytidine Analogues
... their congeners such as the Alexa dyes have been appended to oligonucleotides by linkers to the sugar phosphate backbone or have been tethered to nucleobases. Modifications have also been conjugated to the base or ...
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Absorption, Plasma Transport, and Cellular Retention of Cobalamin Analogues in the Rabbit: EVIDENCE FOR THE EXISTENCE OF MULTIPLE MECHANISMS THAT PREVENT THE ABSORPTION AND TISSUE DISSEMINATION OF NATURALLY OCCURRING COBALAMIN ANALOGUES
... Cbl analogues were bound by plasma transcobalamin II with high affinity and all of these transcobalamin II-[ 57 Co]Cbl analogue complexes were taken up by a variety of tissues in a manner that was ...
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