insulin-like factor 3 (INSL3)
Insulin like factor 3 and the HPG axis in the male
... Insulin-like factor 3 has been described as a “neohormone” (45, 46), i.e., as a hormone which has evolved specifically to address functions uniquely linked to the mammalian phenotype and evo- ...
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Changes in pain and insulin like growth factor 1 in fibromyalgia during exercise: the involvement of cerebrospinal inflammatory factors and neuropeptides
... We studied MMP3 in CSF for its potential role in structural reorganization and inflammation and found that change in CSF MMP-3 correlated negatively with change in pain threshold, which supports the notion that ...
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Insulin like growth factors and insulin like growth factor binding proteins in mammary gland function
... growth factor β receptor [58]. Interestingly, IGFBP-3 and IGFBP-5 have nuclear localiza- tion sequences and are found in the nucleus of T47D human breast cancer cells, which may indicate an intracel- lular ...
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... countries like India ...linked insulin-like growth factor-I & -II (IGF-I & IGF-II) and insulin- like growth factor binding protein-3 (IGFBP-3) with ...
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Association between insulin-like growth factor-binding protein-3 polymorphism -202 A/C and the risk of prostate cancer: a meta-analysis
... one study because of its heterogeneity and publication bias, the P-value was evaluated to be 0.131, and the fixed effects model was consequently used. Then, the results demonstrated that the rs2854744 polymorphism was ...
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Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men
... Despite these strengths, our study still has some limita- tions. First, our study was conducted retrospectively, which carries an intrinsic bias. Second, our discovery stage study was performed using MassARRAY iPLEX ...
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Association of Insulin-like Growth Factor I and Insulin-like Growth Factor–Binding Protein-3 With Intelligence Quotient Among 8- to 9-Year-Old Children in the Avon Longitudinal Study of Parents and Children
... CI: ⴚ 1.67 to 3.78), of IQ. There was no evidence that associations with overall IQ differed between boys and girls. In a data set with complete information on con- founders (n ⴝ 484), controlling for birth weight ...
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Acute effects of physical exercise on the serum insulin like growth factor system in women with fibromyalgia
... Serum samples were collected from the cubital vein in the fasting state at rest at baseline (0), after 15 min cycling and 30 min of rest after the bicycling was terminated (45 min). Biological markers were analyzed by ...
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Insulin-like growth factor binding protein-3 links obesity and breast cancer progression
... in vitro to support breast cancer cell survival in response to hypoxia, glucose starvation and DNA-damaging agents [10, 11]. As an example of the complexity underlying IGFBP-3 activity, the ...
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Epithelial-to-mesenchymal transition in breast cancer: a role for insulin-like growth factor I and insulin-like growth factor–binding protein 3?
... by insulin and found that a key transcription factor upregulated in EMT, Twist, was one of the most upregulated genes and that Twist was key in mediating the antiapoptotic effects of IGF-I in NWTb3 ...
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Adult growth hormone deficiency treatment with a combination of growth hormone and insulin like growth factor 1 resulting in elevated sustainable insulin like growth factor 1 and insulin like growth factor binding protein 3 plasma levels: a case report
... both insulin-like growth factor (insulin-like growth factor-1) and insulin-like growth factor binding protein ...
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Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer
... of insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), and insulin-like growth factor bind- ing ...
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... catenin, insulin (IN)/insulin-like growth factor 1 (IGF-1)/ insulin receptor substrate 1 (IRS1)/phosphatidylinositol-3-ki- nase (PI3K)/protein kinase B (Akt), and IN/IGF-1/IRS1/ ...
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A characteristic signature of insulin-like growth factor (IGF) axis expression during osteogenic differentiation of human dental pulp cells (hDPCs): Potential co-ordinated regulation of IGF action
... We found that under basal conditions, hDPCs express IGFBPs 2 – 6 (Fig. 1a), while IGFBP-1 mRNA was not detected. By qRT-PCR the order of mRNA abundance was BP4 > BP5 > BP2 = BP6 > BP3. Next we examined changes ...
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Growth and Biochemical Markers of Growth in Children With Snoring and Obstructive Sleep Apnea
... ABSTRACT. Objective. The pathophysiological mecha- nisms of growth impairment frequently associated with the obstructive sleep apnea syndrome (OSAS) in chil- dren are poorly defined. The main objective of this study was ...
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Insulin like growth factor type 1 deficiency in a Moroccan patient with de novo inverted duplication 9p24p12 and developmental delay: a case report
... 9p duplication is a structural chromosome abnormality first described by Rethoré and colleagues [1]. To date more than 150 cases have been reported; however, the duplication is often due to a parental reciprocal balanced ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... substrate (IRS) and Shc adaptor proteins (Figure 2). IRS and Shc adaptor proteins then recruit additional factors to yield activations of two major cascades, the phosphatidyl inositol 3-kinase (PI3K) and the ...
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Intravenously injected insulin like growth factor (IGF) I/IGF binding protein 3 complex exerts insulin like effects in hypophysectomized, but not in normal rats
... hypophysectomized, but not of normal rats. The serum half-lives of the two components of the complex were similar to each other, but considerably shorter in hypox than in normal rats. On neutral gel filtration of serum ...
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Expression of the insulin-like growth factor (IGF) system and steroidogenic enzymes in canine testis tumors
... the insulin-like growth factor regulatory system, such as insulin-like growth factor-I (IGF-I) and IGF-II, are involved in the pathobiology of neoplasia, both in terms of the ...
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Combined sprint and resistance training abrogates age differences in somatotropic hormones
... in insulin-like growth factor-1 (IGF-1)has been attributed, in part, to decreased secretion of growth hormone (GH), the main secretagogue of ...the insulin-like growth factor- ...
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