Insulin Receptor
Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance
... the insulin receptor gene from three patients with genetic syndromes associated with extreme insulin ...patients, insulin resistance was caused by decreased insulin binding to the cell ...
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Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene
... the insulin receptor ...the insulin receptor gene in EBV-trans- formed lymphoblasts from two insulin resistant ...extreme insulin resistance with acanthosis nigri- cans (type A ...
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Insulin receptor biosynthesis in cultured lymphocytes from insulin resistant patients
... extreme insulin resistance, the cause of insulin resistance is a marked (greater than or equal to 90%) reduction in the number of insulin receptors on the cell ...of insulin receptor ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an oral glucose ...
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Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes
... humans, insulin resistance is partially due to decreased insulin receptors and insulin receptor kinase ...the insulin receptor ...
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Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle A potential mechanism for insulin resistance in the polycystic ovary syndrome
... the receptor since no insulin receptor gene mutations were identified, immunoprecipitation before autophosphorylation corrected the phosphorylation defect and control insulin receptors mixed ...
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Insulin Resistance in Pregnancy Is Correlated with Decreased Insulin Receptor Gene Expression in Omental Adipose: Insulin Sensitivity and Adipose Tissue Gene Expression in Normal Pregnancy
... of insulin sensitivity to gene expression in omental and subcuta- neous adipose tissue of non-obese, non-diabetic pregnant ...of insulin resistance (HOMA-IR) were calculated from glucose and insulin ...
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Studies on the mechanism of insulin resistance in the liver from humans with noninsulin dependent diabetes Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity
... controls. Insulin binding per cell number was similar in all ...However, insulin binding per surface area was decreased in the two obese groups because their hepatocytes were ...detergent-extractable ...
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Glucocorticoid regulation of insulin receptor and substrate IRS 1 tyrosine phosphorylation in rat skeletal muscle in vivo
... glucocorticoid-induced insulin resistance might originate from abnormalities in insulin receptor signaling, we investigated the effects of glucocorticoids on in vivo tyrosine phosphorylation of the ...
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Effects of Autoantibodies to the Insulin Receptor on Isolated Adipocytes: STUDIES OF INSULIN BINDING AND INSULIN ACTION
... the insulin receptor have been detected in the sera of several patients with the Type B syndrome of insulin resistance and acanthosis ...the insulin receptor in isolated rat ...the ...
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Characterization of antibodies to the insulin receptor: a cause of insulin resistant diabetes in man
... precipitation with specific anti-human immuno-globulins. Although predominantly IgG, some activity is found in the IgM fraction of the immunoglobulins in one patient. The inhibitory immunoglobulins reacted with antisera ...
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Autoantibodies to the Insulin Receptor: EFFECT ON THE INSULIN RECEPTOR INTERACTION IN IM 9 LYMPHOCYTES
... reduce receptor affinity through combined effects on the insulin association and dissociation rates, and, additionally, have smaller effects on available receptor ...available receptor number ...
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Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B
... vertebrates, insulin acts as a specialized metabolic hor- mone regulating glucose homeostasis, whereas IGFs retain their mitogenic ...several insulin-like growth factors genes but only one receptor, ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... on insulin receptor phosphorylation was mainly related to IRS-1 ...that insulin resistance may affect the treatment ef fi cacy and pro- long the course of the ...in insulin-resistant ...
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Analysis of the gene sequences of the insulin receptor and the insulin sensitive glucose transporter (GLUT 4) in patients with common type non insulin dependent diabetes mellitus
... the insulin receptor (IR) and the insulin-sensitive glucose transporter ...of insulin resistance in NIDDM, we have sequenced the entire coding region of the GLUT-4 gene from DNA of six NIDDM ...
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Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... with insulin resistance, salt sensitivity and non-dipper hypertension ...the insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) gene polymor- phisms in ...
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The insulin receptor and the molecular mechanism of insulin action
... This was further validated by the cDNA cloning, which indicated that the intracellular domain of the a-subunit of the insulin receptor is highly homologous with several other tyrosine pr[r] ...
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Direct Demonstration of Separate Receptors for Growth and Metabolic Activities of Insulin and Multiplication stimulating Activity (an Insulinlike Growth Factor) Using Antibodies to the Insulin Receptor
... inhibited insulin binding by 90%, whereas it inhibited MSA binding ...anti-insulin receptor Fab is without intrinsic biological activity, but acts as a competitive inhibitor of insulin ...of ...
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Effects of nano-curcumin on gene expression of insulin and insulin receptor
... with insulin antibody showed many variable sized and shaped islets with strong insulin positivity and no CD 105-positive cells in pancreatic tissue or fat, the difference in the time of appearance of β ...
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Expression and function of the insulin receptor substrate proteins in cancer
... IRS-1 involvement in regulating tumor cell proliferation was foreshadowed by its role in somatic growth regula- tion. IRS-1 null mice are approximately 30% smaller than wildtype littermates and they maintain their runted ...
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