insulin receptor gene expression
Insulin Resistance in Pregnancy Is Correlated with Decreased Insulin Receptor Gene Expression in Omental Adipose: Insulin Sensitivity and Adipose Tissue Gene Expression in Normal Pregnancy
... increased insulin sensitivity because it is the rate-limiting enzyme in ...increased insulin sensitivity include other TCA and glycolytic pathway genes (Table 1), 1,4-alpha-glucan-branching enzyme 1 (GBE1) ...
12
Complex cis regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator
... Fig. 2. Mapping of FOXO- and ecdysone-responsive elements. (A) Overall structure of the InR gene and scheme for the reporter library. The intronic regions of InR were divided into 25 fragments. Each fragment ( ∼ ...
13
Cellular distribution of insulin degrading enzyme gene expression Comparison with insulin and insulin like growth factor receptors
... both insulin and IGFs and has been proposed to play a role in signal termination after binding of these peptides to their ...with insulin receptor (IR) and IGF-I receptor (IGFR) gene ...
9
Expression and function of the insulin receptor substrate proteins in cancer
... IRS expression, there is also evi- dence that the expression of IRS-1 could correlate negatively with tumor ...but expression decreases in more poorly differentiated, higher-grade tumors ...IRS-1 ...
15
TMPRSS2-ERG fusion protein regulates insulin-like growth factor-1 receptor ( IGF1R ) gene expression in prostate cancer: involvement of transcription factor Sp1
... IGF1R gene has been identified as a downstream target of a series of disrupted transcription ...EWS gene to the 3′ exons of the WT1 gene, constitutes the distinctive hallmark of desmoplastic small ...
18
“Effect of Amaryl and Variety of Dietary Supplementations on Gene Expression Alteration in Pancreas, Liver and Ovarian Tissues of Hyperglycemic Rats” by Mariam G. Eshak, Wagdy K. B. Khalil, Ibrahim M. Farag, Somia A. Nada, Egypt.
... of insulin secretion or facilitate post-receptor insulin sensibility as a way of potentiating the insulin ...of insulin at adipocytes by increasing intracellular triglyceride synthesis ...
10
RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass
... muscle insulin sensitivity and glucose uptake, and decreased antimyogenic and inflammatory gene expression in muscle, such as myostatin and protein tyrosine phosphatase ...
11
Rett Syndrome: Treatment with IGF-1, Melatonin,
... receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I. 448[r] ...
13
PubMedCentral-PMC4798554.pdf
... I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor ...the insulin receptor substrate (IRS) adaptor ...
12
Insulin like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production
... The gene expression of the mouse orthologs of these genes is presented in an unsupervised hierarchical clustering ...clear gene groups were observed: group A containing genes associated with ...
15
Effects of nano-curcumin on gene expression of insulin and insulin receptor
... with insulin antibody showed many variable sized and shaped islets with strong insulin positivity and no CD 105-positive cells in pancreatic tissue or fat, the difference in the time of appearance of β ...
10
Rabson Mendenhall Syndrome caused by a novel missense mutation
... Rabson Mendenhall syndrome (RMS) is a rare auto- somal recessive disorder characterized by severe insulin resistance due to mutations in insulin receptor gene (INSR gene). It is ...
5
Food restriction in young Japanese quails: effects on growth, metabolism, plasma thyroid hormones and mRNA species in the thyroid hormone signalling pathway
... mRNA expression of either TR α or TR β between same aged ad libitum fed and experimental ...predominant receptor expressed in the liver, these adjustments in TR β expression were probably not very ...
8
Chronic exposure of betaTC 6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator
... decreased insulin gene transcription and decreased binding activities of two b -cell specific transcription factors, STF-1 and the RIPE3b1 activator, and have suggested that these events may provide a ...
7
Peripheral nervous system insulin resistance in ob/ob mice
... (PNS) insulin signaling is a proposed mechanism that may contribute to sensory neuron dysfunction and diabetic ...Neuronal insulin resistance is associated with several neurological disorders and recent ...
11
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
... its expression in osteoblasts may contribute to its metabolic ...proliferation, insulin secretion, and insulin ...osteocalcin expression and decreased expression of Esp, a gene ...
13
Mitochondrial dysfunction in patients with primary congenital insulin resistance
... LDLR gene, which produce high LDL cholesterol, and premature atherosclerotic disease (16), establishing that high levels of LDL cholesterol are causally linked to ...
6
Relationship between polymorphism of insulin receptor gene, and adiponectin gene with PCOS
... Menzaghi et al, found a significant association between the ADIPOQ polymorphism and waist circumference, blood pressure and insulin level (32). Factors contributing to the different results of various studies ...
10
Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey
... human insulin receptor has two isoforms derived from alternative splicing of exon 11 of the insulin receptor ...binds insulin with twofold lower affinity than the type A (lacking exon ...
9
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle
... muscle insulin receptor content in MIRKO mice were examined dur- ing a 2-hour hyperinsulinemic-euglycemic clamp in awake MIRKO and control ...plasma insulin concentrations were increased by ...
8