Insulin receptor substrate (IRS)-3
Insulin receptor phosphorylation, insulin receptor substrate 1 phosphorylation, and phosphatidylinositol 3 kinase activity are decreased in intact skeletal muscle strips from obese subjects
... 0.9). Insulin- stimulated 2-deoxyglucose uptake was 53% lower in muscle strips from obese ...M insulin for 2, 15, or 30 ...the insulin receptor and insulin receptor ...
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Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI ...
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Erythroid Cells Rendered Erythropoietin Independent by Infection with Friend Spleen Focus-Forming Virus Show Constitutive Activation of Phosphatidylinositol 3-Kinase and Akt Kinase: Involvement of Insulin Receptor Substrate-Related Adapter Proteins
... phosphatidylinositol 3-kinase (PI 3-kinase) after Epo stimulation plays an important role in erythroid cell proliferation and differentiation, we carried out studies to determine if this pathway was also ...
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Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus
... the IRS-1 gene have a hyperreactive platelet phenotype and increased risk of major adverse cardiac events ...the IRS-1 gene which doesn’t affect amino acid coding and protein ...the 3 ′ region of the ...
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Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... IR: insulin resistance; IRS: insulin receptor substrate; JAK‑STAT : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: ...
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Original Article Insulin receptor substrate-2 (IRS-2) rs1805097 G>A polymorphism is associated with colorectal cancer susceptibility: a meta-analysis involving 11,234 subjects
... have insufficient power to obtain a conclusive result, probably due to certain limitations such as small sample size. Meta-analysis is consid- ered a powerful way for pooling the conflicting findings from different ...
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Original Article MicroRNA-126 acts as a tumor suppressor in glioma cells by targeting insulin receptor substrate 1 (IRS-1)
... Malignant gliomas are the most common pri- mary tumors of the central nervous system with high morbidity and mortality [1, 2]. The high lethality of the disease is mainly because of the highly invasive/migratory nature ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Insulin receptor substrate (IRS) docking proteins are the key downstream signaling molecules in the insulin receptor (IR) signaling ...The IRS is spread widely in the ...
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... whether IRS is an in vivo substrate for Pim protein kinases, MEF cells derived from wild type (WT) and triple knockout of Pim1, Pim2 and Pim3 (TKO) FVB mice were ...lane 3 to ...and 3 by ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an oral ...
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Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... the insulin receptor sub- strate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) gene polymorphisms in patients with MetS and 2) to examine the relationships be- tween ...
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Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin receptor signaling by high glucose lev- els and by TNF- a was recently observed in different cell sys- ...–induced insulin receptor inhibition and to compare the consequences of ...
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Differential regulation of insulin receptor substrates 1 and 2 (IRS 1 and IRS 2) and phosphatidylinositol 3 kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
... sulin-stimulated IRS-1 phosphorylation in muscle was de- creased by 68% (P 5 ...while IRS-2 phosphorylation was decreased by 72% in muscle of these obese diabetic mice (P , ...upon insulin ...
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... catenin, insulin (IN)/insulin-like growth factor 1 (IGF-1)/ insulin receptor substrate 1 (IRS1)/phosphatidylinositol-3-ki- nase (PI3K)/protein kinase B (Akt), and IN/IGF-1/IRS1/ ...
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Original Article Histone deacetylase 6 promotes insulin resistance via deacetylating phosphatase and tensin homolog (PTEN) in ovarian OVCAR-3 cells
... Polycystic ovary syndrome (PCOS) is a hetero- geneous gynaecological syndrome, which is often characterized by the manifestation of oligo/anovulation, clinical or biochemical hyper- androgenism and/or polycystic ovaries, ...
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Insulin resistance differentially affects the PI 3 kinase– and MAP kinase–mediated signaling in human muscle
... both insulin receptor and IRS-1 tyro- sine phosphorylation by 15 minutes, and this level of phosphorylation was sustained for at least 30 ...minutes. Insulin receptor and IRS-1 ...
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The pathophysiology of insulin resistance and modulation by aerobic exercise in obese and Type 2 diabetes subjects
... The role o f soluble C5b-9 (sC5b-9) in human P-cell functioning is uncertain. When comparing sC5b-9 in diabetes patients Bergamaschini et al. (28) found that there was no significant difference in juvenile or adult onset ...
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Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies
... kinase receptor that functions by phosphorylating the substrate to stimulate cellular re- ...VEGF receptor (VEGFR) consists of an extracellular domain, a single transmembrane spanning re- gion, and ...
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Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes
... the insulin receptors in obese patients with and without noninsulin dependent diabetes mellitus (NIDDM) and in nonobese controls using partially purified receptors from muscle ...biopsies. Insulin binding ...
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PubMedCentral-PMC4798554.pdf
... 1. IRS adaptor protein isoforms define tumor cell biology and regulate global gene expression ...is IRS-dependent. cDNA microarray analysis was performed on IRS-null YA, IRS-1, and ...
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