Insulin Receptors
The role of hepatic insulin receptors in the regulation of glucose production
... of insulin receptors in the liver do not affect the ability of insulin to inhibit HGP prompts the question: How did the fall in HGP reported by Buettner et ...of insulin on the ...hepatic ...
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Hypoglycemic effect of insulin like growth factor 1 in mice lacking insulin receptors
... of insulin receptors ...IGF-1 receptors and increased the levels of the phosphatidylinositol-3-kinase p85 subunit detected in antiphosphotyrosine immunoprecipitates, consistent with the possibility ...
8
The Interactions of Proinsulin with Insulin Receptors on the Plasma Membrane of the Liver
... constant essentially accounts for the reduced affinity of proinsulin for the insulin receptors. The possibility of proinsulin conversion at the insulin receptor sites was investigated. Material ...
13
Ontogenesis of somatomedin and insulin receptors in the human fetus
... and insulin receptors in ...and insulin was examined at the different ...separate insulin and IGF-2 receptors. The Scatchard plots of insulin binding to liver membranes were ...
12
Demonstration and partial characterization of insulin receptors in human platelets
... bind insulin. To examine whether human platelets contain specific insulin receptors, washed human platelets suspended in Hepes buffer were incubated at 24 degrees C with 125I-insulin in the ...
7
Defect in cooperativity in insulin receptors from a patient with a congenital form of extreme insulin resistance
... in insulin receptors from a patient with a genetic form of extreme insulin resistance ...(leprechaunism). Receptors from this insulin-resistant child are characterized by two ...
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Concentrations of Insulin and of Insulin Receptors in the Brain are Independent of Peripheral Insulin Levels: STUDIES OF OBESE AND STREPTOZOTOCIN TREATED RODENTS
... of insulin and insulin receptors throughout the central nervous systsem, we have examined extreme conditions of hyperinsulinemia (obese mice) and hypoinsulinemia (streptozotocin-treated rats) with ...
8
Acute regulation of human lymphocyte insulin receptors Analysis by the glucose clamp
... lymphocyte insulin receptor model has been used to explore the regulation of insulin receptor appearance in that lymphocytes do not bear the insulin receptor in the circulation and thus are not ...
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Insulin Receptors in Cystic Fibrosis: Increased Receptor Number and Altered Affinity
... Neufeld, Angeline Smith and Marilyn Insulin Receptors in Cystic Fibrosis: Increased Receptor Number and Altered Affinity. Services[r] ...
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Decreased kinase activity of insulin receptors from adipocytes of non insulin dependent diabetic subjects
... between insulin binding and activation of the receptor kinase. The insulin receptor kinase defects observed in NIDDM could be etiologically related to insulin resistance in NIDDM and the pathogenesis ...
12
Cloning and characterisation of Schistosoma japonicum insulin receptors
... providing insulin to cells inside the worm for development and/or ...host insulin, which is a specialized function used by the parasite to exploit a host hormone, with the IR-1 homologue having been lost by ...
13
Insulin Receptors
... Much of the emphasis in the pathogenesis of diabetes mellitus has justifiably been placed on the endocrine gland, the pancreas. Extensive studies on the biosynthes[r] ...
5
Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action
... for insulin, while the number of receptor sites per cell remained ...while insulin-stimulated rates decreased 6 to ...and insulin-stimulated rates of 2-deoxy-glucose uptake was seen from 24-72 h of ...
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Evidence for presence of insulin receptors in rat islets of Langerhans
... and insulin concentration and depended on the number of incubated ...bound insulin was displaced by native insulin in a dose- dependent ...of insulin binding by native insulin revealed ...
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Insulin receptor biosynthesis in cultured lymphocytes from insulin resistant patients
... extreme insulin resistance, the cause of insulin resistance is a marked (greater than or equal to 90%) reduction in the number of insulin receptors on the cell ...of insulin receptor ...
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Muscle cell electrical hyperpolarization and reduced exercise hyperkalemia in physically conditioned dogs
... Insulin receptor density in monocytes increases as a result of training 39; Although the specific effect of endurance training on insulin receptors has not been studied in muscle, studie[r] ...
7
Insulin resistance and pancreatic β cell failure
... Mice that lack insulin receptors in adipocytes are lean and are protected against obesity-related glucose intolerance 7, suggesting that insulin signaling in adipocytes per se may not co[r] ...
6
Disulfide reduction converts the insulin receptor of human placenta to a low affinity form
... These results suggest that reduction of a critical disulfide RESULTS bond in insulin receptors from human placenta converts The effect of DTT on insulin binding to placenta the receptor [r] ...
5
Effect of specific dietary constituents on coronary heart disease risk factors
... the insulin receptors activity/number in the liver which increased the heaptic insulin clearance, and possibly led to a reduced SNS activity and hence lower energy expenditure especially in people ...
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Elevated insulin receptor content in human breast cancer
... of insulin receptors in surgical specimens of breast ...the insulin receptor content was ...The insulin receptor content in breast cancer tissues was also higher than in any normal tissue ...
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