Integrin alpha V
Involvement of integrin alpha V gene expression in human melanoma tumorigenicity
... of alpha v integrins on the tumorigenicity of human ...lack alpha v gene expression and thus fail to express integrin alpha v beta 3 (M21-L ...1 integrin expression ...
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Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin
... to integrin alpha v beta ...of alpha v beta 3 on the metastatic cells as compared to the parent ...the alpha v beta 3 receptor plays a role in the process of lymphatic ...
9
Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5
... internalization via alpha v beta 5, an effect dependent on the vitronectin in serum. We conclude that pleural mesothelial cells recognize and internalize vitronectin- and serum- coated asbestos via the ...
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Arginine-glycine-aspartic acid-specific binding by foot-and-mouth disease viruses to the purified integrin alpha(v)beta3 in vitro.
... a v b 3, bind to their ligands by recognizing the tripeptide RGD ...a v b 3 is now known to recognize the RGD tripeptide in up to nine different protein ligands (16, ...for integrin-ligand ...
5
A concise review of magnetic resonance molecular imaging of tumor angiogenesis by targeting integrin αvβ3 with magnetic probes
... with histological characteristics of tumors (ie, microvessel densities and α v β 3 expression levels) at different growth stages. In order to further improve the detection specificity, dual-targeting approach, ...
11
Exploration of peptide T7 and its derivative as integrin αvβ3-targeted imaging agents
... binding kinetics between T7 and T7-6H, with an introduction 6 histidine into the C-terminus of the T7 peptide, and an analysis of α v β 3 density in the in vitro cell lines and in vivo animal models. We used a ...
9
Insulin like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo
... While integrin-mediated adhesion may be neces- sary for tumor cell motility and invasion, it is not ...the integrin a v b 5, facilitating attachment to ...a v b 5 require a tyrosine kinase ...
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Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation
... Prostate Cancer (PCa) is the second most frequent can- cer and the fifth leading cause of cancer death in men, mainly due to distant metastasis [1]. The validation of molecular markers able to refine the prognostic ...
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Integrin Alpha V Beta 3 Matrix Metalloproteinase 2 (MMP 2), Cross Talk
... cells may play a very important role in determining the invasive property and malignant behavior of tumor tissues. The positive expression of endogenous inhibitor of MMP-2, TIMP-2 may have an appreciable role in ...
10
Nanotetrac targets integrin αvβ3 on tumor cells to disorder cell defense pathways and block angiogenesis
... α v β 3, as antibody to the integrin may, but selectively manipulates the functions of the integrin, so that apoptosis is fostered and antiapoptosis defenses are ...
6
Cloning of the Xenopus integrin alpha(v) subunit and analysis of its distribution during early development
... Int J De, Hiol ~2 171 179 (1998) 171 Origil/al Arlirl,' Cloning of the Xenopus integrin CJ vsubunit and analysis of its distribution during early development THOMAS O JOOS", WOLFGANG E REINTSCH, ACHIM[.] ...
9
Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis
... the integrin alpha v/beta 3 has been reported as a mediator of anchorage independence [21], and its expression has been associated with an aggressive form of disease in different human tumors ...
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Insilico and Electron Microscope Study about Attachment of Mesenchymal Stem Cell Derived from Stromal Vascular Fraction to Scaffold (Bovine Bone Cancellous, Hydroxyapatite-Calcium Sulphate, Calcium Phosphate)
... was Integrin Alpha V to Hydroxyapatite which need a total energy of ...and Integrin Beta 2 to Hydroxyapatite which need a total energy of ...
6
PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase
... cells. Indeed, on bone, the presence of these cells was neces- sary for the activation of OCLs including the formation of F-actin rings and of resorption pits (25). In addition, in the ab- sence of MB1.8 cells, pOCs ...
13
Extracellular Vesicle Integrins Distinguish Unique Cancers
... certain integrin proteins that may, in turn, promote cell detachment, migration, and selection of future metastatic ...distinct integrin profiles of these cancer ...of integrin receptors in breast ...
13
Interleukin-8 promotes integrin β3 upregulation and cell invasion through PI3K/Akt pathway in hepatocellular carcinoma
... 8]. Integrin α v β 3, as an important cell surface adhesion molecule, has also been reported to be overexpressed in cancer tissues and mediate the invasion and metastasis of HCC cells [13 – ...and ...
10
The role of [alpha]3[beta]1 integrin in cortical development
... α3 integrin by Parvalbumin promoter-driven Cre recombinase does not alter neuronal ...α3 integrin- mediated interactions are not required for the final differentiation of cortical neurons following neuronal ...
102
β1 and β4 integrins: from breast development to clinical practice
... – integrin axis regulates many crucial cellular functions including survival, migration and quiescence; the imbalance in any of these processes could contribute to ...prominent integrin subunits, β 1 and β ...
9
Low expression allele alpha LELY of red cell spectrin is associated with mutations in exon 40 (alpha V/41 polymorphism) and intron 45 and with partial skipping of exon 46
... The alpha V/41 polymorphism of erythroid alpha-spectrin has been characterized initially by an increased susceptibility to proteolysis of the alpha IV-alpha V domain junction ...
7
Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma
... α v β 3 in osteosarcoma and clinicopathological characteristics The osteosarcoma patients’ clinicopathological charac- teristics are summarized in the Additional file 1: Table ...and integrin αvβ3 was ...
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