Integrin signaling
Perspectives series: cell adhesion in vascular biology Integrin signaling in vascular biology
... and signaling functions of integrins are critical for their biological ...vasculature, integrin signaling events play central roles in an- giogenesis, cell migration during development and wound re- ...
6
Angiopoietin 2 differentially regulates angiogenesis through TIE2 and integrin signaling
... the integrin adaptor protein FAK, resulting in RAC1 activation, migration, and sprouting ...with integrin signaling and inhibited FAK phosphorylation and sprouting angiogenesis of TIE2 lo ...and ...
16
Analysis of the role of the integrin signaling pathway in hepatocytes during rat liver regeneration
... the integrin signaling pathway ...ECM/integrin signaling via elimination of integrin-linked kinase (ILK) in hepatocytes interferes with signals, leading to termination of liver ...
15
Integrin signaling to the actin cytoskeleton.pdf
... between integrin engagement and FAK activation in the pathway [59 ...the integrin avb3 but not with a5b1 [60 ...avb3 integrin signaling via a Src family kinase is involved in the reinforcement ...
11
The adaptor protein Disabled-2: new insights into platelet biology and integrin signaling
... adhesion, integrin α IIb β 3 activation, fibrinogen uptake, and intracellular signaling of the megakaryocytic ...at integrin α IIb β 3-bound ...and integrin α IIb β 3 activation stimulated by ...
7
β4 Integrin signaling induces expansion of prostate tumor progenitors
... α6β4 integrin (referred to herein as β4 integrin because β4 pairs only with α6) binds to laminin-5, a major component of the basement membrane of the prostate (22), and is characterized by a ...
19
Integrin signaling modes controlling cell migration and metastasis
... α5β1 integrin to bind soluble fibronectin supports the activity of ...α5β1- integrin-specific residues in the cytoplasmic domains do not underlie α5β1-integrin-stimulated RhoA ...α5β1 integrin ...
132
Phospho Tyrosine(s) vs Phosphatidylinositol Binding in Shc Mediated Integrin Signaling
... mediated signaling events control numerous developmental, physiological and pathological processes in multicellular ...of integrin acti- vation [1] [2], the early intracellular events following the ...
15
Use of an immobilized monoclonal antibody to examine integrin α5β1 signaling independent of cell spreading
... studies, integrin ligation to the ECM is analyzed by allowing cell attachment to an ECM protein pre- coated solid ...example, integrin α5β1 is a major receptor for fibronectin (FN), while integrins α4β1 and ...
7
Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues
... determined integrin-associated signaling molecules that become activated, probably as a result of inflammation in RA ...with integrin-signaling complexes by binding to Src kinase and paxillin ...
10
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3
... an integrin signaling pathway that inhibits CNTF expression, involving FAK, JNK and the S727 residue of the transcription factor STAT3 ...whether integrin or FAK signaling interacts with ...
15
beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones
... Integrin signaling has been shown to be critical for axon guidance and cell migration, either as a direct receptor or as a modulator of guidance signaling ...that integrin signaling ...
14
Notch controls urothelial integrity in the mouse bladder
... 4 integrin in urothelial cell ...(40). Integrin signaling has been implicated in key cellular processes, including regu- lation of cell proliferation (41) and tissue homeostasis (42), while ...
16
Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion
... actin polymerization within 20 sec, but pre-treatment with deguelin for 1 h strongly diminished SDF-1α-induced actin polymerization (Figure 6A). Furthermore, phalloidin immunofluorescence showed that treating cultured ...
13
Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression
... with integrin α11 assessed by coimmunoprecipitation and immunofluorescence ...classical integrin/ ECM signaling, integrin/RTK crosstalk is already documented for several RTKs, including EGFR, ...
21
Integrins in invasive growth
... Integrin signaling promotes cell migration by inducing changes in the cytoskeletal organization and by increas- ing cellular contractility (Figure ...different integrin signaling pathways ...
9
Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling
... mouse, zebrafish and Xenopus (Georges-Labouesse et al., 1996; Hynes, 2002; Jülich et al., 2005; Koshida et al., 2005; Kragtorp and Miller, 2007; Yang et al., 1999). Somites are the segmented anlagen of the skeletal ...
9
<p>Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target</p>
... 63–65 Integrin αvβ3 directly interacts with the ...of integrin clustering following integrin engagement and is activated through undefined mechan- ...ERK signaling pathway is a common path- ...
12
Role of Rho GTPases and PTEN in the migration of human glioma cells
... Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways, J Cell Biol 143,1375-83. Proliferation[r] ...
215
Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis
... Fig. 1. Loss of Dnm2 regulates VEGF signaling but reduces angiogenesis. (A) Loss of DNM2 or CHC (50 nM of each) reduces transferrin endocytosis in HUVECs. n=4 experiments. Inset shows knockdown efficiency of ...
8