interferon alpha-induced proteins
Bovine Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Cooperatively Antagonize Alpha/Beta Interferon-Induced Antiviral Response
... both proteins are required and also suf- ficient to interfere with the establishment of an antiviral state was obtained by using rRV expressing individual NS ...NS proteins, at appro- priate stoichiometric ...
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Viral Protein VP4 Is a Target of Human Antibodies Enhancing Coxsackievirus B4- and B3-Induced Synthesis of Alpha Interferon
... The six coxsackievirus B (CVB) serotypes (CVB1 to CVB6), together with echovirus serotypes, EV-69, and swine vesicular disease virus, belong to the Human enterovirus B species of the Enterovirus genus within the ...
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Mechanisms of action of interferon-alpha in B-cell chronic lymphocytic leukaemia
... of interferon on cellular events has made a comprehensive understanding of the direct effects of interferon on malignant cells extremely ...to interferon-alpha, but they also vary in their ...
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Efficient Virus Assembly, but Not Infectivity, Determines the Magnitude of Hepatitis C Virus-Induced Interferon Alpha Responses of Plasmacytoid Dendritic Cells
... Assembly of infectious HCV progeny proceeds through several distinct steps, including (i) trafficking of core protein to lipid droplets, (ii) recruitment of NS5A and viral RNA to lipid droplets, (iii) capsid envelopment, ...
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Interaction of interferon alpha therapy with thyroid function tests in the management of hepatitis C: a case report
... of interferon alpha on the immune system that leads to its therapeutic actions are also re- sponsible for the development of ...to interferon alpha receptors, which are transmembrane ...
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Negative Regulation of the Alpha Interferon-Induced Antiviral Response by the Ras/Raf/MEK Pathway
... There is a significant body of literature implicating Ras ac- tivation in viral infection and replication (4, 9, 12, 16, 59). Reovirus was the first virus reported to specifically kill cancer cells harboring ...
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Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis
... The alpha- viral plus-sense RNA genome and subgenomic mRNAs are all capped, but since these viruses do not encode 2=-O-methyltrans- ferases, they would be expected to be highly susceptible to inhibi- tion by ...
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Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication
... Alpha/beta interferon (IFN- ␣ /  ) produces antiviral effects through upregulation of many interferon-stimulated genes (ISGs) whose protein products are effectors of the antiviral ...the ...
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Coronavirus Pseudoparticles Formed with Recombinant M and E Proteins Induce Alpha Interferon Synthesis by Leukocytes
... There is now substantial evidence that IFN-a synthesis can be triggered by inert viral structures, indicating that replication and/or gene expression is not required for efficient IFN induc- tion at least in certain ...
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Interferon-alpha-induced deficits in novel object recognition are rescued by chronic exercise
... Interferons are a family of multi-functional, pleiotropic proteins belonging to the cytokine family of proteins. They are produced by the body in response to viral infections and tumors; key functions ...
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Interferon-alpha-induced deficits in novel object recognition are rescued by chronic exercise
... Permanent repository link: http://openaccess.city.ac.uk/5755/ Link to published version: http://dx.doi.org/10.1016/j.physbeh.2008.05.008 Copyright and reuse: City Research Online aims to[r] ...
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Antiviral and protein-inducing activities of recombinant human leukocyte interferons and their hybrids.
... Like natural human leukocyte interferon, each of the seven species of recombinant interferons induced the synthesis of at least five proteins in human fibroblasts, whereas induction of o[r] ...
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Recognition of herpesviruses by the innate immune system
... Second, while it is clear that detection of classical PAMPs is central to immune surveillance, we also believe that the innate immune system can sense viral infections through other mechanisms. It seems likely that novel ...
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Interferon-induced proteins in human fibroblasts and development of the antiviral state.
... The induction of these proteins had features in common with the development of the antiviral effect of interferon, such as i sensitivity to actinomycin D and cycloheximide when these com[r] ...
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Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
... an interferon response, STATs are ini- tially phosphorylated and IFNα signaling is initiated and re- solved quickly, but during chronic inflammation STATs lose their phosphorylation status even in the presence of ...
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AIM2 Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA
... 50. Rice GI, Kasher PR, Forte GM, Mannion NM, Greenwood SM, Szynkiewicz M, Dickerson JE, Bhaskar SS, Zampini M, Briggs TA, Jenkinson EM, Bacino CA, Battini R, Bertini E, Brogan PA, Brueton LA, Carpanelli M, De Laet C, de ...
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Activation of Heat Shock Protein Induced by Curcumin to Prevent Huntington Disease- an Analytical Approach in the Context of Protein Vibration
... Abstract Depending on aggregate size, amino acid sequence and degree of misfolding, protein aggregates are disaggregated by Heat Shock Proteins (HSPs). Natural products can induce SHPs. Curcumin- the chemical ...
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Alpha interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes.
... 7559-7565 0022-538X/94/$04.00+0 Copyright X 1994, American Society for Microbiology Alpha Interferon-Induced Antiretroviral Activities: Restriction of Viral Nucleic Acid Synthesis and Pr[r] ...
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The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins
... were induced for 72 h and infected with WT CHIKV or VEEV, as well as with VEEV-G3A, which encodes an attenuating mutation in the 5=nontranslated region that was acquired during cell adaptation of the TC83 vaccine ...
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Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response
... Although interferon alpha/beta was not detected in this study, the major transcription factor of interferon alpha/beta synthesis, IRF7, was up- regulated after ...Many interferon ...
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