Interferon-γ release assay
Whole Blood Interferon γ Release Assay Is Insufficient for the Diagnosis of Sputum Smear Negative Pulmonary Tuberculosis
... an interferon-γ release assay (IGRA) for the diagnosis of active pulmonary tuberculosis (PTB) among sputum smear negative PTB suspects in an environment with intermediate burden of PTB and ...
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Usefulness of interferon-γ release assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province, China
... immunosorbent assay; ESAT-6: 6-kDa early secretory antigenic target; IFN- γ : Interferon- γ ; IGRA: Interferon- γ release assay; NTM: Non-tuberculosis mycobacteria; ...
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Original Article Application of interferon-γ release assay in extrapulmonary tuberculosis diagnosis, T-lymphocyte regulation, and efficacy evaluation in Northwest China
... the interferon-γ release assay (IGRA) has become a widely accepted means for the diagnosis of tuberculosis (TB), there are limited data on IGRA performance in the diagnosis of extrapulmonary ...
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Interferon-γ Release Assay Performance for Tuberculosis in Childhood
... Our analysis has several limitations. Our cohort was tested predominately with enzyme-linked immunosorbent assay-based IGRA (QFT) and so provides little insight into the performance of enzyme-linked immunospot ...
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Accuracy of the interferon γ release assay for the diagnosis of active tuberculosis among HIV seropositive individuals: a systematic review and meta analysis
... A total of 1,743 studies were identified after searching in the EMBASE, Cochrane and MEDLINE databases. After the full text of the articles was assessed for eligibility, 11 studies met our selection standards and were ...
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Interferon γ release assay as a sensitive diagnostic tool of latent tuberculosis infection in patients with HIV: a cross sectional study
... Over the last years, IGRA has gained ground as an alternative to the TST because it can detect the IFN-γ secreted by circulating lymphocytes T cells when stim- ulated by specific TB antigens. It can be measured in ...
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Malnutrition and Helminth Infection Affect Performance of an Interferon γ–Release Assay
... technicians who were blinded to all clinical information. Briefly, blood was collected into 3 heparin-containing tubes, including a positive control (mitogen, phytohemagglutinin), a negative control (heparin), and a ...
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The clinical utility of tuberculin skin test and interferon γ release assay in the diagnosis of active tuberculosis among young adults: a prospective observational study
... We prospectively enrolled all individuals 20 to 29 years old who were highly suspect for TB at the Armed Forces Capital Hospital, a central military referral hospi- tal in Korea, between May 2008 and September 2009. ...
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Evaluation of the tuberculin skin test and the interferon-γ release assay for TB screening in French healthcare workers
... The increased risk of healthcare workers (HCWs) for tuberculosis is well established [1,2]. Therefore screening healthcare workers (HCWs) for latent tuberculosis infec- tion (LTBI) and active tuberculosis (TB) is ...
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Screening for tuberculosis and the use of a borderline zone for the interpretation of the interferon-γ release assay (IGRA) in Portuguese healthcare workers
... 16. Ringshausen FC, Nienhaus A, Torres Costa J, Knoop H, Schlösser S, Schultze-Werninghaus G, Rohde G: Within-subject variability of mycobacterium-tuberculosis-specific interferon-gamma responses in German health ...
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Diagnostic value of the interferon γ release assay for tuberculosis infection in patients with Behçet’s disease
... neurologic involvement (15%), cardiac involvement (9.8%) and hematological involvement (5.2%). The median BDCAF2006 score for disease activity was 2 (range 0–5). Elevated erythrocyte sedimentation rate (ESR) and ...
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Performance of the tuberculin skin test and interferon γ release assay for detection of tuberculosis infection in immunocompromised patients in a BCG vaccinated population
... The moderate concordance between the TST and QFT-IT (κ = 0.57, p < 0.001) in the immunocompetent group in contrast with the fair concordance of the TST and QFT-IT (κ = 0.38, p 0.001) in the immunocompromised group ...
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Characteristics of peripheral Vγ2Vδ2 T cells in interferon γ release assay negative pulmonary tuberculosis patients
... Vγ2Vδ2T cells were reported to play an important role in host immunity resistant to M. tuberculosis [33]. It was showed that Vγ2Vδ2T cells kill intracellular bacilli through killing of macrophages harboring live MTB; ...
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Geiwagner, Christina (2018): Einfluss einer Narkose auf die Vitalität peripherer Leukozyten und die Entwicklung eines Interferon-gamma (IFN-y) release assays für die Untersuchung von Rotwildblut. Dissertation, LMU München: Tierärztliche Fakultät
... IFN-γ release assay bereits erfolgreich eingesetzt werden und brachte weitreichende Erkenntnisse bezüglich der TB-Verbreitung durch diese Spezies (TOMLINSON et ...IFN-γ release ...
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Contribution of a heparin binding haemagglutinin interferon gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV infected patients: comparison with the tuberculin skin test and the QuantiFERON® TB Gold In tube
... the assay without modifying its specificity ...the assay to be considered posi- tive, as this interpretation method has been previously vali- dated and increases the specificity of the test ...
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Diagnosis of Congenital Toxoplasmosis by Using a Whole Blood Gamma Interferon Release Assay
... gamma interferon (IFN- ␥ ) response after stimulation of whole blood by crude parasitic ...the assay was ...our assay is well adapted for the study of congenital toxoplasmosis in ...
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Sensitivity Analysis and Potential Uses of a Novel Gamma Interferon Release Assay for Diagnosis of Tuberculosis
... Study assessments and measurements. (i) Gamma interferon release assay. Manufacturer’s instructions were followed precisely for the IGRA. The IGRA (QuantiFERON-TB Gold In-Tube; Cellestis Ltd., ...
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Effector mechanisms of interleukin 17 in collagen induced arthritis in the absence of interferon γ and counteraction by interferon γ
... There is considerable evidence that IL-17 contributes to the inflammation associated with rheumatoid arthritis (RA). IL-17 is spontaneously produced by RA synovial membrane cultures and high levels of IL-17 were detected ...
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Specificity of QuantiFERON TB Plus, a New Generation Interferon Gamma Release Assay
... ABSTRACT Interferon gamma release assays (IGRAs) are important tools in identifying prior tuberculosis ...(QFT-Plus) assay, recently approved for use in the United States, differs from the ...
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<p>Current approaches in the grading and management of cytokine release syndrome after chimeric antigen receptor T-cell therapy</p>
... Cytokine release syndrome (CRS) and CAR-associated neurotoxicity, which can occur independently or concurrently with CRS, are two potentially life-threatening toxicities of CAR T-cell ...
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