Interferon-gamma Release Tests
Interferon Gamma Release Assays for Latent Tuberculosis: What Are the Sources of Variability?
... Interferon gamma release assays (IGRAs) are blood-based tests intended for diagnosis of latent tuberculosis infection (LTBI). IGRAs offer logistical advantages and are supposed to offer ...
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Poor agreement between interferon gamma release assays and the tuberculin skin test among HIV infected individuals in the country of Georgia
... diagnostic tests for LTBI in HIV pa- tients in the Eastern European ...diagnostic tests (QFT- GIT, TSPOT, and TST) including between the two different commercially available ...the tests reflects ...
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Comparison of Sensitivities of Two Commercial Gamma Interferon Release Assays for Pulmonary Tuberculosis
... There are few head-to-head comparisons of the commercial gamma interferon release assays (GIRAs). We compared the performance of the T-SPOT.TB and QuantiFERON-TB Gold In-Tube (QFT-IT) assays in ...
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Tuberculin Skin Testing and Treatment Modulates Interferon-Gamma Release Assay Results for Latent Tuberculosis in Migrants
... None of the eight day 0 positive QFT-GIT individuals reverted to negativity. However 15 (9.5%) previously negative individuals converted to positivity, nearly tripling the numbers of positive individuals to 23 (13.9%) on ...
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Value of the tuberculin skin testing and of an interferon gamma release assay in haemodialysis patients after exposure to M tuberculosis
... T-cell Interferon-gamma (IFN-γ) release assays, known as IGRAs, are emerging as new screening tools for the detection of ...commercial tests are available: the Quantiferon W -TB Gold In-Tube ...
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Diagnosis of Congenital Toxoplasmosis by Using a Whole Blood Gamma Interferon Release Assay
... ␥ release assay is a good marker of congenital toxo- plasmosis, and it has also been reported previously to be ef- fective for diagnosing perinatal tuberculosis (4); neither the stage of pregnancy at maternal ...
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Assessment of Imprecision in Gamma Interferon Release Assays for the Detection of Exposure to Mycobacterium tuberculosis
... New gamma interferon (IFN- ␥ ) release assays (IGRAs) to detect an exposure to Mycobacterium tuberculosis have recently been ...skin tests (TSTs) in the diagnosis of latent tuberculosis (TB) ...
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Risk Factors Associated with Indeterminate Gamma Interferon Responses in the Assessment of Latent Tuberculosis Infection in a High-Incidence Environment
... of gamma interferon (IFN- ␥ ) release assays (IGRA) in the detection of latent tuberculosis (TB) infection is lim- ited by the higher rates of indeterminate results in HIV-infected persons, who bear ...
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Specificity of QuantiFERON TB Plus, a New Generation Interferon Gamma Release Assay
... and the risk of progression if the individual is infected, utilization of the results from two tests (IGRA or TST) is recommended. This strategy is in line with prior recommendations (27, 28). The results from our ...
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Contribution of a heparin binding haemagglutinin interferon gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV infected patients: comparison with the tuberculin skin test and the QuantiFERON® TB Gold In tube
... Effect of Mtb exposure risk, BCG vaccination status and HIV infection parameters on the LTBI screening test results A non-random association between baseline test results and selected variables (Mtb exposure risk factor, ...
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Systematic review and meta analysis on the utility of Interferon gamma release assays for the diagnosis of Mycobacterium tuberculosis finfection in children: a 2013 update
... Debord and colleagues evaluated QFT-G-IT perfor- mance restrospectively in 19 French immunocompetent children (median age: 1.52 years) with active tuberculosis [28]. The rate of indeterminate results was 0/19 and the ...
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Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: a latent-class analysis
... diagnostic tests are ...these tests have considerably lower sensi- tivity than TST in immune-competent populations than had previously been demonstrated ...these tests; whereas our study included ...
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Within-Subject Variability of Mycobacterium tuberculosis-Specific Gamma Interferon Responses in German Health Care Workers
... available gamma interferon (IFN- ␥ ) release assays (IGRAs) QuantiFERON-TB Gold In-Tube (QFT; Cell- estis, Carnegie, Australia) and ...blood tests avoid sensitization, the boosting of immune ...
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Sensitivity Analysis and Potential Uses of a Novel Gamma Interferon Release Assay for Diagnosis of Tuberculosis
... Strategies for screening individuals suspected of having pul- monary TB using both the IGRA and TST or IGRA and single sputum smear for AFB could have attractive negative predic- tive values, given the high sensitivity ...
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Contribution of Interferon gamma release assays testing to the diagnosis of latent tuberculosis infection in HIV infected patients: A comparison of QuantiFERON TB Gold In Tube, T SPOT TB and tuberculin skin test
... blood tests to evaluate cell-mediated immune response against Mycobacterium tuberculosis ...The interferon-gamma release assays (IGRAs) measure T-cell release of interferon-γ ...
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Point Counterpoint: Should Interferon Gamma Release Assays Become the Standard Method for Screening Patients for Mycobacterium tuberculosis Infections in the United States?
... The IGRAs are not without disadvantages to the laboratory, however. The reagents are more expensive than a single- or even two-step TST. The blood for the QFT-GIT must be appropriately incubated within 16 h of ...
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IGRA tests perform similarly to TST but cause no adverse reactions: pediatric experience in Finland
... Skin Tests; (TU): Tuberculin Unit; (IGRA): Interferon Gamma Release Assays; (TB): Tubercu- losis; (LTBI): Latent Tuberculosis Infection; (BCG): Bacille Calmette-Guérin; (SOP): Standard ...
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Evaluation of Gamma Interferon and Antibody Tuberculosis Tests in Alpacas
... blood tests for the antemortem diagnosis of tuberculosis (TB) in South American camelids ...the gamma interferon (IFN-␥) release assay, two lateral flow rapid antibody tests (Stat-Pak ...
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Comparison of the Cytomegalovirus (CMV) Enzyme Linked Immunosorbent Spot and CMV QuantiFERON Cell Mediated Immune Assays in CMV Seropositive and Seronegative Pregnant and Nonpregnant Women
... two interferon gamma release assays (IGRA), the CMV enzyme- linked immunosorbent spot (ELISPOT) and CMV QuantiFERON assays, detecting CMV-specific CMI were ...Statistical tests, including ...
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Detection of latent tuberculosis infection among migrant farmworkers along the US Mexico border
... the interferon gamma release assays (IGRA) such as the Quantiferon TB gold- In-Tube ...these tests in detecting LTBI in the US-Mexico border region, and none in Southwest Arizona ...
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