Interferon-inducible
Duck Interferon-Inducible Transmembrane Protein 3 Mediates Restriction of Influenza Viruses
... Interferon-inducible transmembrane proteins (IFITMs) can restrict the entry of a wide range of viruses. IFITM3 localizes to en- dosomes and can potently restrict the replication of influenza A viruses (IAV) ...
14
Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In Vitro
... Interferon-inducible transmembrane protein 3 (IFITM3) is an effector protein of the innate immune system. It confers potent, cell-intrinsic resistance to infection by diverse enveloped viruses both in vitro ...
10
Inhibition of Hepatitis B Virus Replication by the Interferon-Inducible MxA Protein
... Human MxA is an alpha/beta interferon-inducible intracytoplasmic protein that mediates antiviral activity against several RNA viruses. We had previously shown that overexpression of the hepatitis B virus ...
8
EFFICACY OF INTERFERON-INDUCIBLE PROTEIN-10 FOR MONITORING STANDARD TUBERCULOSIS TREATMENT
... problem. Interferon-inducible Protein-10 (IP-10) has been proposed as a promising biomarker for monitoring the efficacy of s t a n d a r d therapy in patients with active pulmonary ...Conclusion: ...
11
Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit Influenza A Virus Replication
... he interferon-inducible transmembrane proteins (IFITMs) were identified as potent inhibitors of different viruses, in- cluding influenza A virus (IAV), West Nile virus, severe acute respiratory syndrome ...
8
Use of type I interferon inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti IFNα antibody, in systemic lupus erythematosus
... I interferon-inducible mRNAs were identifi ed as over- expressed in each of the three diff erent ...I interferon-inducible mRNAs that could be used in a high-throughput PD biomarker assay to ...
7
Investigation of antiviral state mediated by interferon inducible transmembrane protein 1 induced by H9N2 virus and inactivated viral particle in human endothelial cells
... I interferon binds to interferon-α/β receptors and activates JAK-STAT signaling pathway, resulting in the expression of hundreds of interferon- stimulated genes (ISGs) ...host. ...
12
The Interferon-Inducible Gene viperin Restricts West Nile Virus Pathogenesis
... I interferon (IFN) signaling coordinates an early antiviral program in infected and uninfected cells by inducing IFN-stimulated genes (ISGs) that modulate viral entry, replication, and ...
10
The interferon inducible antiviral protein Daxx is not essential for interferon mediated protection against avian sarcoma virus
... We previously demonstrated that treatment with IFN-α results in induction of Daxx mRNA in HeLa cells [3]. To evaluate Daxx protein levels following IFN treatment, we treated HeLa or DF-1 cells with either human or ...
5
Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon
... I nnate immune responses play a crucial role in combating invading pathogens by sensing pathogen-associated molecular patterns, initiating signaling cascades culmi- nating in secretion of numerous proinflammatory ...
20
Interferon-inducible chemokines reflect severity and progression in sarcoidosis
... elevated levels of IFN-γ-inducible chemokines in BALF [10–13], we hypothesized that circulating blood levels of the IFN-γ-inducible chemokines, CXCL9 and CXCL10, would reflect disease severity and clinical ...
9
Expression of interferon-inducible genes in RD-114 cells.
... This suggested that IFN--y-induced synthesis of a putative mRNA whose translation product was needed for synergistic interaction with IFN-ot Consistent with this model, synergistic induc[r] ...
8
Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection.
... Binding sites from IFN-3, ISG15, and GBP promoters provide targets for activation by cotransfection of an ISGF2 expression vector, and transcription of the corresponding endogenous genes[r] ...
9
MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups
... an interferon-inducible gene, MxA , is highly upregulated in cells of FA complementation groups A, B, C, and D, but it is suppressed in FA group C cells complemented with wild-type FAC cDNA as well as in ...
9
Deficiency for the ER-stress transducer OASIS causes severe recessive osteogenesis imperfecta in humans
... the Interferon-inducible transmembrane protein 5 (IFITM5), which is involved in bone growth during pre- natal murine development, was recently shown to cause autosomal (AD) dominant OI ...
6
Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells
... many interferon-inducible genes were prominently up- regulated in TCDD-treated human AEC; the increase of gene expression of IFITM1, G1P2, IFI27 and IFIT1 was equal to or far more than that of CYP1A1 and ...
9
Interferon γ inducible protein 16 (IFI16) is required for the maintenance of Epstein Barr virus latency
... Interferon ? inducible protein 16 (IFI16) is required for the maintenance of Epstein Barr virus latency RESEARCH Open Access Interferon ? inducible protein 16 (IFI16) is required for the maintenance o[.] ...
12
The Role of MyD88 in the Host Defense and Inflammatory Response Following Leptospira interrogans Infection of the Heart.
... and interferon-inducible genes were significantly upregulated at 1 day ...of interferon induction were dysregulated in MyD88-deficient mice, offering a potential explanation for the lower leptospiral ...
101
IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon Gamma Induced Factors To Restrict Intracellular Replication of Legionella pneumophila
... M acrophages are preferred host cells for many species of intracellular bacterial pathogen. Bona fide pathogens of mammals, such as Mycobacterium tuberculosis, Listeria monocytogenes, and Salmonella enterica, as well as ...
15
Interleukin-6, MCP-1, IP-10, and MIG are sequentially expressed in cerebrospinal fluid after subarachnoid hemorrhage
... (MCP-1), interferon- γ -inducible protein-10 (IP-10), and monokine induced by interferon- γ (MIG) in the CSF of ten patients with SAH were measured using ELISA kits over a period of 14 ...
6