Interleukin 1 (IL1)
Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect
... e.g. interleukin-1 (IL1), IL6, and tumor necrosis factor alpha (TNFα) are elevated in syn- ovial fluid aspirates from patients following ACL injury and play an important role in the initial disease ...
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The involvement of proinflammatory cytokines in diabetic nephropathy: Focus on interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α) signaling mechanism
... About 20-40% of type 2 diabetic patients may develop diabetic nephropathy (DN) as its complication. The pathogenesis of DN is complex. Classically, metabolic and hemodynamic impairment are considered as its pathogenesis. ...
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Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
... cytokine interleukin-1 (IL-1) and the CNS-abundant, lipid-cholesterol-carrying protein apolipoprotein E (ApoE) are key participants in the pathogenesis of Alzheimer’s disease ...
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Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... I interleukin-1 (IL-1) receptor (IL-1RI) signaling complex using immunoprecipitation and tandem mass ...to interleukin-1 receptor-associated kinase ...
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Effect of hypothermia on interleukin-1 receptor antagonist pharmacodynamics in inflammatory-sensitized hypoxic-ischemic encephalopathy of term newborns
... [11–14]. Interleukin-1 receptor antagonist (IL-1Ra) has already demonstrated a protective perinatal efficacy on several organs, especially the brain, exposed to inflammation induced by bacterial compounds ...
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Role of Interleukin 1 Alpha (IL 1α) and Interleukin 1 Receptor Antagonist (IL 1RA) in Pathogenesis of Juvenile Idiopathic Arthritis and Adult Onset Rheumatoid Arthritis of Iraqi Patients
... patients. Interleukin-1 is an inflammatory cytokine that has multiple properties and almost all types of cells are affected by ...systemic 1 is involved the induction of adhesion molecules expression ...
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Interleukin 1 stimulates fibroblasts to produce granulocyte macrophage colony stimulating activity and prostaglandin E2
... Granulocyte-macrophage colony-stimulating activity (GM-CSA) can be produced by a variety of normal cell types including mononuclear phagocytes, activated T lymphocytes, endothelial cells, and fibroblasts. Recent evidence ...
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Differences in the Levels of Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1ra) in Children with Status Epilepticus and Febrile Seizure
... ated with tissue damage, which is the underlying cause of morbidity and mortality in meningoencephalitis [14]. This study also showed that IL-1ra levels were ele- vated in all groups (reference value 0.2 ng/mL). How- ...
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Interleukin 1 receptor antagonist A new member of the interleukin 1 family
... suggestive of a cytoplasmic (not secretory) protein, and may only be released after cellular injury. Furthermore, although IL-1ra possesses a leader sequence, 50% or more of this protein remains cell associated. Do these ...
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The inhibitory activity of human interleukin 1 receptor antagonist is enhanced by type II interleukin 1 soluble receptor and hindered by type I interleukin 1 soluble receptor
... inducing signal transduction; and IL-1 soluble receptors (IL-1sR) which bind IL-1 and diminish the free concentration of soluble cytokine, thus hampering its binding to the cell surface receptor. Since ...
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Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells
... responses in several different tissues. In these studies we demonstrate that three biological properties of human monocyte-derived IL-1 (T-lymphocyte activation and human synovial cell prostaglandin E2 and ...
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Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1 Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163 171
... production by IL-1 is dependent on protein synthesis. The synthetic human IL-1 beta peptide 163-171 (Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys), which has been previously shown to stimulate thymocyte ...
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Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice
... of interleukin-1 β (IL1 β ), interleukin-6 (IL-6), tumor necrosis factor α (TNF- α ), interferon γ -inducible protein 10 (IP10), and toll-like receptor 4 mRNA were assessed in the hippocampus ...
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Differential expression of pro inflammatory cytokines IL 15Ralpha, IL 15, IL 6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients
... cytokines interleukin 1 (IL1), tumour ne- crosis factor alpha (TNFalpha), and interleukin 6 (IL6), in particular, have been identified and intra-articular as well as systemic levels of these ...
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Association of IL1 beta gene polymorphism and allograft functions in renal transplant recipients :a case control study from Kashmir Valley
... Renal Transplantation is the treatment of choice for end stage renal disease (ESRD). However, acute rejection (AR) remains important clinical problems accounting for chronic allograft loss and suboptimal long-term ...
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Effect of frankincense oil on the neurochemical changes induced in rat model of status epilepticus
... leading eventually to neuronal injury, gliosis and cog- nitive impairment [6, 9]. In addition, both clinical studies and experimental models provided evidence implicating inflammatory cytokines in the induction and ...
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Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock
... antagonist, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-alpha, intercellular adhesion molecule-1, high mobility group box- 1, D-Dimer and caspase-3), and organ ...
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Granulocyte-Macrophage Colony-Stimulating Factor Amplification of Interleukin-1β and Tumor Necrosis Factor Alpha Production in THP-1 Human Monocytic Cells Stimulated with Lipopolysaccharide of Oral Microorganisms
... chemotherapy. Interleukin-1 b (IL-1 b ) and tumor necrosis factor alpha (TNF- a ) play important roles in inflammatory processes, including exacerbation of periodontal diseases, one of the most ...
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Immunotherapy of brain metastases: breaking a “dogma”
... IL: Interleukin; IL-10: Interleukin-10; IL-1 β : Interleukin-1 β ; IL- 23: Interleukin-23; IL-6: Interleukin-6; IL-8: Interleukin-8; Ir: Immune-related; iRANO: ...
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Determination of Changes in Blood Biomarker Levels in Antipsychotic Polypharmacy and Aripiprazole Monotherapy in Patients With Long-term Schizophrenia
... as Interleukin 2 (IL-2) and Inter- leukin 6 (IL-6) are altered in the serum of schizophrenic patients with an upstream regulation of inflammatory cytokines and some of their receptors, such as anti-in- flammatory ...
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