Interleukin 12
Characterizing Intravesical Delivery of Chitosan/Interleukin-12 for the Immunotherapy of Bladder Cancer.
... of interleukin-12 in the biopolymer chitosan ...(CS/IL-12). Interleukin-12 is a potent T H 1 polarizing cytokine whose permeation into the bladder is enhanced via ...
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Role of Interleukin-12 in Primary Influenza Virus Infection
... Interleukin-12 (IL-12) is a 70-kDa heterodimeric cytokine composed of a 40-kDa heavy chain (p40) and a 35-kDa light chain (p35) (27, 53). IL-12 is produced by monocytes, macro- phages, B ...
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Interleukin-12 (IL-12), but Not IL-23, Deficiency Ameliorates Viral Encephalitis without Affecting Viral Control
... by interleukin-12 (IL-12), which in concert with the related cytokine IL-23, participates in regulating both innate and adaptive immune responses (15, 18, 26, 31, ...
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Mechanisms by Which Interleukin 12 Corrects Defective NK Cell Anticryptococcal Activity in HIV Infected Patients
... ABSTRACT Cryptococcus neoformans is a pathogenic yeast and a leading cause of life-threatening meningitis in AIDS patients. Natural killer (NK) cells are important immune effector cells that directly recognize and kill ...
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Potential immunotherapeutic role of interleukin-2 and interleukin-12 combination in patients with hepatocellular carcinoma
... All tissue culture media contained RPMI-1640 medium (Sigma Aldrich, St Louis, MO, USA), 10% heat-inactivated FCS ( Biochrom AG, Berlin, Germany), and 100 U/mL of penicillin and 100 µ g/mL of streptomycin (Biochrom). ...
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Interleukin-12 inhibits hepatitis B virus replication in transgenic mice.
... Interleukin-12 (IL-12) is a heterodimeric cytokine produced by antigen-presenting cells that has the ability to induce gamma interferon (IFN- g ) secretion by T and natural killer cells and to ...
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Interleukin-12 exhibits potent antiviral activity in experimental herpesvirus infections.
... of interleukin-12 was studied by using murine models of herpes simplex virus ...of interleukin-12 given 48 and 24 h prior to ...of interleukin-12 commenced 6 h after the mice ...
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Interleukin-12 Peripheral Blood Levels in Asthmatic Children
... T he prevalence of atopic asthma, a T helper (Th)2- dependent disease, is reaching epidemic proportions, possibly owing to improved hygiene in industrialized countries. 1 The chronic inflammation of the airways in asthma ...
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The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells
... Dynamics of VAMP7 and IL-12 Polarization at the IS In order to gain a dynamic picture of polarization events occur- ring in DCs upon synapse formation and to resolve the kinetic of VAMP7 redistribution, we ...
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Antibodies to hepatitis B virus surface antigen and interleukin 12 and interleukin 18 gene polymorphisms in hemodialysis patients
... IL12 and IL18 share biological properties through their synergism in the promotion of IFN-gamma production [11-13,40,41]. IL12, generated by macrophages, mono- cytes, dendritic cells, and B cells, is significantly ...
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A Correlative Study of Interleukin-12 and Cortisol in HIV Patients with Depression
... Five millilitres of blood was drawn in an EDTA tube between 4 to 4:30 pm and immediately centrifuged at 3,800 rpm for 10 min. Plasma was stored at −20°C until thawing for assay. The plasma levels of IL-12 and ...
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Effect of anti interleukin 12 treatment on murine lyme borreliosis
... responses in the genesis of disease caused by Borrelia burgdorferi. Infection of inbred mice with B. burgdorferi results in varying degrees of arthritis: BALB/c mice develop mild disease and C3H mice develop severe ...
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Interleukin 12 and interleukin 18 synergistically induce murine tumor regression which involves inhibition of angiogenesis
... Inhibition of angiogenesis mediated by SCK.12 and SCK.18 cells. The rechallenge data indicated that protective immunity did not develop in half of mice given SCK.12C or SCK.12C plus SCK.18A cells. Antitumor ...
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Accelerated wound healing phenotype in Interleukin 12/23 deficient mice
... A potential role for IL-12 and IL-23 in wound heal- ing is suggested by IL-12 having anti- angiogenic activ- ity which is mediated through its effects on promoting secretion of IFN-g [14], which in turn ...
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Beta2 agonists prevent Th1 development by selective inhibition of interleukin 12
... could also inhibit IL-12 production by DC, we stimulated hu- man monocyte-derived DC with IFN-g and J558 cells express- ing the CD40 ligand in the presence or absence of salbutamol (Fig. 6 A). Production of ...
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Regulation of CD154 induced interleukin 12 production in synovial fluid macrophages
... = interleukin; LPS = lipopolysaccharide; mAb = monoclonal antibody; MACS = magnetic cell sorting; PB = peripheral blood; PBMC = peripheral blood mononuclear cell; RA = rheumatoid arthritis; RF = rheumatoid factor; ...
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Interleukin-12 Is the Optimum Cytokine To Expand Human Th17 Cells In Vitro
... Our data indicate that a single cytokine (IL-2, IL-7, IL-15, IL-12, or IL-23) significantly increases the level of IFN- ␥ se- creted by CD4 ⫹ IL-23R ⫹ cells in comparison to the level for nonstimulated cells, in ...
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Histamine inhibits the production of interleukin 12 through interaction with H2 receptors
... ducible cAMP early repressor) has been described that inhib- its IL-2 promoter activity (40). This mechanism probably in- volves binding of ICER to cAMP responsive elements (CRE), thereby inhibiting transactivating ...
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Differential effects of interleukin-12, interleukin-15, and interleukin-2 on human immunodeficiency virus type 1 replication in vitro.
... These attributes of IL-12 and IL-15 suggest that they may have a role in treatment of HIV disease. The recent finding that HIV-1 replication is the central driving force for loss of CD4 1 T cells argues that ...
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Review of ustekinumab, an interleukin-12 and interleukin-23 inhibitor used for the treatment of plaque psoriasis
... The long-term side effects of ustekinumab are unknown and the majority of answers will come from post-marking studies and physician experience. Adverse events reported in clinical trials have been relatively mild, with ...
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