Interleukin-13
Identifying the Roles of Interleukin 13 in Childhood Asthma
... Asthma is a chronic inflammatory disease of the airways manifested by reversible airflow ob- struction and airway hyperresponsiveness. While recent research has mapped several genes as possible factors predisposing to ...
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Original Article The rs20541 G>A polymorphism in the interleukin 13 gene is associated with a decreased risk of renal cell carcinoma in a Chinese population
... Abstract: Renal cell carcinoma (RCC) has multifactorial etiology and is the most common form (≥85%) of renal cancer. We conducted a hospital-based case-control study of 132 RCC cases and 145 matched controls to assess ...
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Molecular Expression Analysis of Restrictive Receptor for Interleukin 13, a Brain Tumor-associated Cancer/Testis Antigen
... High-grade glioma cell lines A-172 MG, U-373 MG, U-251 MG and human glioblastoma mul- tiforme explant cells isolated in our laboratory, G-48, were grown in culture-appropriate me- dia. Total RNA was extracted from the ...
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Interaction of prenatal maternal smoking, interleukin 13 genetic variants and DNA methylation influencing airflow and airway reactivity
... Background: Asthma is characterized by airflow limitation and airway reactivity (AR). Interleukin-13 (IL-13) is involved in the pathogenesis of asthma. Two functional SNPs, rs20541 and rs1800925, of ...
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Effects of Interleukin 13 and Montelukast on the Expression of Zonula Occludens 1 in Human Podocytes
... by interleukin-13 (IL-13) in the experi- mental minimal-change nephrotic syndrome (MCNS) model and to determine whether montelukast, a leukotriene receptor antagonist, has an effect on ZO-1 res- ...
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Original Article Association between interleukin-13 gene polymorphism and neonatal asthma in Han nationality Chinese population
... Abstract: Background and objective: Interleukin-13 (IL-13) is an important cytokine secreted from type 2 helper T lymphocytes. Previous studies showed that polymorphisms in the IL-13 gene were ...
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Anti interleukin 13 and anti interleukin 4 agents versus placebo, anti interleukin 5 or anti immunoglobulin E agents, for children and adults with asthma
... signalling. Interleukin-13 is a pleiotropic cytokine produced by type 2 helper T cells (TH ), and has been shown to drive airway eosinophilia and increase airway inflammation in ...asthma. ...
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Interleukin 13 receptor α2 DNA prime boost vaccine induces tumor immunity in murine tumor models
... the interleukin 13 receptor (IL-13R) a2 chain is overexpressed on certain types of human cancers includ- ing glioblastoma, head and neck, kidney, ovarian, breast, and Kaposi ’ s sarcoma ...
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Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model
... Detrimental inflammatory responses in the central nervous system (CNS) are a hallmark of various neurodegenerative pathologies, with multiple sclerosis (MS), stroke and trau- matic brain or spinal cord injury being ...
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Immunization of Macaques with Formalin-Inactivated Respiratory Syncytial Virus (RSV) Induces Interleukin-13-Associated Hypersensitivity to Subsequent RSV Infection
... Respiratory syncytial virus (RSV) is a major cause of severe respiratory disease in infants and the elderly. RSV vaccine development has been hampered by results of clinical trials in the 1960s, when formalin- ...
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Interleukin-13 disrupts type 2 pneumocyte stem cell activity
... Understanding the etiology of COPD and pulmonary fibrosis and devising new treatments for both diseases require knowledge of the cellular and molecular mechanisms that regulate the growth and dif- ferentiation of cells ...
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Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium
... We have demonstrated that airway epithelia of asth- matics express more SP-D whereas non-asthmatic differ- entiated ALI cultures have decreases in SP-D expression in parallel with decreasing basal cells (via CK-5 marker) ...
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Altered balance of interleukin 13/interferon gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren’s syndrome
... IL-2 signals through its heterodimer receptor com- posed of three individual chains. CD25 binds IL-2 with high affinity and it is considered its main receptor. Mice lacking CD25 have phenotype similar to mice lacking ...
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Pulmonary expression of interleukin 13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
... Effect on airway fibrosis. Masson’s trichrome stains were used to evaluate the presence and distribution of collagen in the lungs from transgene (–) and transgene (+) animals. As can be seen in Fig. 5, a small amount of ...
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The effect of interleukin-13 (IL-13) and interferon-γ (IFN-γ) on expression of surfactant proteins in adult human alveolar type II cells in vitro
... SP-B and SP-C are synthesized by ATII cell as proSP-B and proSP-C, which are proteolytically processed to mature SP-B and SP-C on route from its site of synth- esis to the lamellar bodies [53,54]. Cathepsin H is one of ...
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CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction
... For double staining, formalin fixed ESCC tissues were deparaffinized and nonspecific bindings were blocked with 5% BSA in PBS for 30mins, RT. Tissues were then incubated with first antibody (rabbit origin) against human ...
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Constitutive Activation of Interleukin-13/STAT6 Contributes to Kaposi's Sarcoma-Associated Herpesvirus-Related Primary Effusion Lymphoma Cell Proliferation and Survival
... tive STAT6 activation in a number of human malignancies (9), including prostate carcinomas (15) and Hodgkin’s lymphoma (16). Mechanistically, STAT6 is constitutively activated in pri- mary mediastinal large B-cell ...
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Original Article miR-330 regulates interleukin-13-induced MUC5AC secretion by targeting Munc18b in human bronchial epithelial cells
... Next, the effects of miR-330 expression on IL-13-induced MUC5AC secretion were explor- ed. HBE16 cells were transfected with miR-330 mimic, miR-330 inhibitor, or their respective controls. After transfection, ...
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Interleukin-13 receptor α2 is associated with poor prognosis in patients with gastric cancer after gastrectomy
... IL13, as the ligand of IL-13Rα2, has numerous biological functions in inflammation and immune responses and potential clinical applications [24]. IL13 could be produce by T and B cells, and nature immune cells such as ...
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In vivo suppression of NF kappa B and preservation of I kappa B alpha by interleukin 10 and interleukin 13
... Preservation of IkBa protein by IL-10 and IL-13. Since IL-10 and IL-13 inhibited NF-kB activation in alveolar mac- rophages and whole lungs (Figs. 5 and 6), we designed experi- ments to determine if the ...
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