Interleukin 15 (IL-15)
Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo
... (17). Interleukin 15 (IL-15) is a potent enhancer of NK cytotoxic function and is under study in oncology, given its potential to improve the clearance of malignant cells ...with ...
13
Interleukin-15 Increases Effector Memory CD8+ T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques
... vivo IL-15 treatment of mice preferentially expands memory CD8 ⴙ T ...of IL-15 treatment in 9 SIVmac251-infected cynomolgus macaques (low dose of IL-15, 10 g/kg of body weight, ...
9
Viral Activation of Interleukin-15 (IL-15): Characterization of a Virus-Inducible Element in the IL-15 Promoter Region
... the IL-2 receptor as well as its own private ␣ chain (IL-15R␣) in T and natural killer (NK) ...cells. IL-15 stimulates T- and B-cell proliferation, lymphokine-activated killer cell induction, ...
12
Original Article Smooth muscle homeostasis in human atherosclerotic plaques through interleukin 15 signalling
... with IL-15 and with IL-15R, sections were first incubated with the unlabeled IL-15 or IL- 15R antibody, followed by incubation with Envi- sion goat ...
8
Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon gamma by natural killer cells in vitro
... Endogenous IL-15 activates NK cells through the IL-2 receptor, and with endogenous IL-12, regulates NK cell IFN-gamma after monocyte activation by ...endogenous IL-15, and as ...
6
Anti-Interleukin-15 Prevents Arthritis in Borrelia-Vaccinated and -Infected Mice
... that IL-15 is a primary mediator involved in the induction of arthritis associated with Borrelia vaccination and infection of ...that IL-15 plays a major role in the induction of arthritis ...
8
Differential effects of interleukin-12, interleukin-15, and interleukin-2 on human immunodeficiency virus type 1 replication in vitro.
... of IL-12 and IL-15 on HIV replication were initiated because these cytokines have fea- tures suggesting that they may enhance cellular ...study, IL-12 and IL-15 had little effect ...
7
Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell-delivered murine leukemia model
... as IL-15 are vital with respect to activating immune cells, sustaining healthy immune functions, and augmenting the anti-tumor activity of effector cells, making them ideal candidates for cancer ...
13
Transpresentation of interleukin‑15 by IL‑15/IL‑15Rα mRNA‑ engineered human dendritic cells boosts antitumoral natural killer cell activity
... produce interleukin (IL)-15 and/or IL-15 receptor alpha (IL‑15Rα) using mRNA ...of IL‑15Rα to the protocol, enabling IL‑15 transpresentation to neighboring ...
11
2018-Garrido-e00235-18.full.pdf
... of interleukin 15 (IL-15) treatment on NK cell function and the potential for stimulated NK cells to clear the HIV ...by IL-15, and, more importantly, IL-15-treated ...
14
Epstein-Barr Virus Coinfection in Children Boosts Cytomegalovirus-Induced Differentiation of Natural Killer Cells
... During childhood, infections with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) can occur in close temporal proximity. Active, as well as latent, CMV infection is associated with enlarged subsets of differentiated ...
10
Histological evaluation of intratumoral myxoma virus treatment in an immunocompetent mouse model of melanoma
... murine interleukin-15 [MYXV-IL15]) were evaluated for therapeutic effects in an aggressive B16F10 melanoma model in immunocompetent ...of IL-15 within a tumor would recruit cytotoxic effector ...
17
IL-15 as a potential target in leukemia
... cells. Interleukin 15, a proinflammatory cytokine, induces proliferation and promotes cell survival of human T and B lymphocytes, as well as natural killer ...of Interleukin 15 and its role in ...
9
Synovial expression of IL 15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor
... The inter-individual variability in synovial staining was high for the cytokines IL-15, IL-1 α , IL-1ß, IFN- γ and TNF, shown in Table 1. The results of both the semi-quantitative analysis and ...
8
Original Article High expression of IL-1β and NFκB in tumor tissue predicts a low recurrence rate of hepatocellular carcinoma
... μm. IL-1β and NFκB were mea- sured using immunohistochemistry, and the anti-IL-1β and anti-NFκB were purchased from Abcam, ...of IL-1β and NFκB, and the remaining cases were classified as being in ...
8
Assessment of Pro-Inflammatory Cytokines Level in Stored Blood for Transfusion in Port Harcourt, Nigeria
... (i.e. IL-4, IL-6, and ...of IL-4, IL-6, and TNF-α was used for the ...of interleukin (4, 6 and TNF-α) concentrations in the plasma of the stored ...
7
Differential expression of pro inflammatory cytokines IL 15Ralpha, IL 15, IL 6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients
... cytokines interleukin 1 (IL1), tumour ne- crosis factor alpha (TNFalpha), and interleukin 6 (IL6), in particular, have been identified and intra-articular as well as systemic levels of these cytokines may ...
8
Elevated levels of circulating IL 7 and IL 15 in patients with early stage prostate cancer
... Serum IL concentrations and acute phase protein titres were evaluated by ...compare IL gene expression and serum titers in the two groups of ...on IL titers. Results: IL-2 and IL-21 ...
9
Inflammatory IL 15 is required for optimal memory T cell responses
... of IL-15. We observed a significant increase in IL-15Rα on den- dritic cells following PV infection, suggesting that, as previously described (28, 29), dendritic cells play an important role in the ...
15
Immunotherapy of brain metastases: breaking a “dogma”
... factor-1; IL: Interleukin; IL-10: Interleukin-10; IL-1 β : Interleukin-1 β ; IL- 23: Interleukin-23; IL-6: Interleukin-6; IL-8: ...
10