Interleukin-1beta
Systemic autoimmune disease in asbestosis rapidly responding to anti interleukin 1beta antibody canakinumab: a case report
... Recently, an important role of interleukin-1beta (IL-1beta) in the pathogenesis of asbestosis and its systemic autoimmune manifestations has been reported [8]. Indeed, asbestos fibers seem to enhance ...
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Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with 31P MRS-detectable energy failure
... Interleukin-1beta -induced changes in blood – brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study.. Moseley[r] ...
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Production of interleukin 1beta by human hematopoietic progenitor cells
... of interleukin 1beta (IL-1beta) by human hematopoietic stem/progenitor cells was studied to explore the concept that these cells are not merely responders to stimuli from their microenvironment, but ...
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Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice
... IL-1β: interleukin- 1beta; MCA: middle cerebral artery; min: minutes; PBS: phosphate buffered saline; PECAM: platelet endothelial cell adhesion molecule-1; PFA: paraformaldehyde; pMCAO: permanent middle ...
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Macrophage derived interleukin 1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro
... Abstract Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microen- vironment are linked to the presence of LVI and ...
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Original Article Shikonin protects chondrocytes from interleukin-1beta-induced apoptosis by regulating PI3K/Akt signaling pathway
... Abstract: Chondrocyte apoptosis is mostly responsible for the development and progression of osteoarthritis. IL-1β is generally served as an agent that induces chondrocyte apoptosis. Shikonin exerts its anti-inflammatory ...
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In vivo effect of interleukin-1beta and interleukin-1RA on oocyte cytoplasmic maturation, ovulation, and early embryonic development in the mare
... the interleukin-1 system is involved in periovulatory ...mare, interleukin-1beta (IL-1beta) increases the ovulatory rate of metaphase II ...and interleukin-1RA (IL-1RA; experiment 1, n ...
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The effect of glycogen depletion on responses of interleukin-1beta, interleukin-6, and interleukin-10 to maximal exercise
... Interleukin-1β did not increase significantly in the CTRL trials, but a small mean peak was noted 2 hours post-exercise. This response seems illogical if its pro-inflammatory role in exercise is similar to that of ...
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Autocrine role of interleukin 1beta in altered responsiveness of atopic asthmatic sensitized airway smooth muscle
... lated in sensitized TSM that were pretreated with either the IL-1 recombinant human receptor antagonist or an IL-1 b – neutralizing antibody. Moreover, extended studies demon- strated that, in contrast to their ...
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Bradykinin stimulates NF kappaB activation and interleukin 1beta gene expression in cultured human fibroblasts
... We first showed that IL-1b synthesis in BK-stimulated WI-38 cells correlated with an increase in the steady state level of IL-1b mRNA, which was the consequence of transcription activati[r] ...
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Epigallocatechin 3 gallate suppresses the global interleukin 1beta induced inflammatory response in human chondrocytes
... : interleukin-1 β ; IP-10: interferon-gamma-inducible protein-10; IRAK-1: interleukin-1 receptor-associated kinase 1; IRB: Institutional Review Board; JNK: cJun-N-termial kinases; LIF: leukemia inhibitory ...
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Evaluation of Brainstem auditory evoked potential and serum Interleukin-1beta levels in patients with generalized tonic clonic seizures
... IL 1β augment nitric oxide formation to raise the seizure susceptibility and also increase the neuronal excitability by directly inhibiting GABA(A)receptors, enhancing NMDA receptor function and inhibiting K efflux 104 ...
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1,25 Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin 1beta production
... inhibition. The growth inhibition was associated with a rapid but transient downregulation of IL-1beta and IL-1beta-converting enzyme (ICE) mRNAs in 1,25D3- and 20-epi analogue- treated cells, and the ...
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Inhibition of interleukin 1beta stimulated dedifferentiation of chondrocytes via controlled release of CrmA from hyaluronic acid chitosan microspheres
... Background: The previous studies indicated that CrmA could ameliorate the interleukin-1 β induced osteoarthritis. In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from ...
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Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin 1beta induced inhibition of long term potentiation in rat dentate gyrus
... Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, has been shown to in- duce profound changes both peripherally and centrally. It has recently been reported that intraperitoneal injec- ...
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Original Article Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro study
... on interleukin-1 beta (IL-1β)-induced glycosaminoglycan (GAG) release, nitric oxide production as well as gene expressions of inflammatory and catabolic mediators in human cartilage and ...
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Differential expression and upregulation of interleukin 1alpha, interleukin 1beta and interleukin 6 by freshly isolated human small intestinal epithelial cells
... The present study shows that significant proportions of freshly isolated human SIEC constitutively express IL-6 and, while mRNA for IL-1a and IL-1b was detectable in normal small intesti[r] ...
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Taurolidine reduces the tumor stimulating cytokine interleukin 1beta in patients with resectable gastrointestinal cancer: a multicentre prospective randomized trial
... We were interested in the effects of the used intraoperative irrigation fluid on morbidity, mortality rates, as well as on perioperative complications. Therefore, the overall rates are shown in Table 2. In ...
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Low innate production of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age.
... particular, interleukin (IL)-1 b and tumor necrosis factor (TNF)- a seem to play a prominent role and are of major importance to cartilage destruction and remodeling of the subchondral bone 4 e 10 ...
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Interleukin-4 inhibits secretion of interleukin-1beta in the response of human cells to mycobacterial heat shock proteins.
... Cellular activation induced by Mycobacterium bovis bacillus Calmette-Gue ´rin (BCG) and heat shock proteins (HSP) leads to the production of proinflammatory cytokines such as interleukin-1 b (IL-1 b ) and IL-6. In ...
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