interleukin-2 receptor (CD25)
Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription
... Glucocorticosteroids have an inhibitory effect on the expression of interleukin 2 (IL-2) and interleukin 2 receptor (IL-2R) genes. To determine the mechanisms of this inhibition, ...
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An interleukin 2 receptor gamma chain mutation with normal thymus morphology
... the interleukin-2 receptor (IL-2R g ...IL-2 receptor, but also participates in the formation of the IL-4, 7, 9, and 15 re- ceptor ...(T 2 B 1 ...
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Novel Role for Interleukin-2 Receptor-Jak Signaling in Retrovirus Transmission
... Virus transmission from HTLV-1-infected T cells occurs through a virological synapse, whereby the microtubule-orga- nizing center (MTOC) and other cytoskeletal components of the cell are reorganized and polarized ...
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Spontaneous expression of the interleukin 2 receptor gene and presence of functional interleukin 2 receptors on T lymphocytes in the blood of individuals with active pulmonary sarcoidosis
... IL 2 receptor (IL 2R) ...IL 2 in vitro, they proliferated at a rate greater than that of normal blood T cells under the same conditions, suggesting that ...
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T cell subpopulations, expression of interleukin 2 receptor, and production of interleukin 2 and gamma interferon in human American cutaneous leishmaniasis
... Leukocyte subpopulations, the expression of the interleukin-2 IL-2 receptor, and the production of IL-2 and gamma interferon IFN--y were studied in the peripheral blood mononuclear cells[r] ...
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Partial restoration of impaired interleukin 2 production and Tac antigen (putative interleukin 2 receptor) expression in patients with acquired immune deficiency syndrome by isoprinosine treatment in vitro
... syndrome (AIDS). In 9 of the 10 patients, production of IL-2 from mononuclear cells and Leu 3(+) cells was depressed; expression of Tac antigen on mononuclear cells and Leu 2(+) cells was found to be ...
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Interleukin 2 receptor (Tac antigen) expressed on adult T cell leukemia cells
... the interleukin-2 (IL-2) receptor and the proliferative response to exogenous IL-2 of peripheral blood leukemic cells from patients with adult T cell leukemia (ATL) in order to see ...
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Interleukin 2 and interleukin 2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures
... The production of IL-1 and IL-6 by pituitary cells has recently been demonstrated. In this study we investigated the expression of IL-2 and its receptor (IL-2R) by pituitary cells of different species. In ...
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Characterization of Immunodeficiency in a Patient With Growth Hormone Insensitivity Secondary to a Novel STAT5b Gene Mutation
... IL, interleukin; GH, growth hormone; JAK, Janus kinase; STAT, signal transducer and activator of transcription; GHR, growth hormone receptor; IL-2R, interleukin 2 receptor; Treg, ...
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Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross sectional study
... soluble interleukin-2 receptor (sIL-2R) and interleukin (IL)-6, and an osteo-destruction marker, deoxypyridinoline, in synovial fluid (SF) samples obtained from 22 HTLV-I carriers and 58 ...
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Linker-scanning mutational analysis of the transcriptional activity of the human immunodeficiency virus type 1 long terminal repeat.
... LTR transcriptional activity obtained by using NXS mutants in Jurkat cells Spl, TATA, LBP-1, UBP-2 a NRE, Negative regulatory element; IL-2, interleukin-2; IL-2Ra, interleukin-2 receptor[r] ...
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Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein
... the interleukin-2 receptor (IL-2R), interleukin-4 receptor (IL-4R), and interleukin-10 receptor (IL-10R) binding domains, and we showed that purified IrmA can bind to ...
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Low dose temozolomide before dendritic cell vaccination reduces (specifically) CD4+CD25++Foxp3+ regulatory T cells in advanced melanoma patients
... TMZ treatment with respect to DCR patients (−76.4% versus −30.2%, respectively). Furthermore, a +400% increase in Foxp3+Tregs was seen in the PD group after IL-2 administration, whereas values of these lympho- ...
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PTEN regulates IL 2 receptor responsiveness of CD4+CD25+ regulatory T cells
... stimulated with IL-2 (100 U/ml), irradiated APCs, and varying doses of anti-CD3 (2C11) as shown for 72 hours. Tritiated thymidine was added to cultures for the final 16 hours before harvesting. Data shown repre- ...
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Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9
... HEPES, 2 mM ethylenediaminetetraacetic acid (EDTA) and an EDTA-free protease inhibitor cocktail tablet and centri- fuged at 15,000 × g for 30 minutes at ...
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Interleukin 35 modulates the balance between viral specific CD4+CD25+CD127dim/ regulatory T cells and T helper 17 cells in chronic hepatitis B virus infection
... elevated in both CHB and ASC [17]. It was also accepted that Tregs and other cell types (including activated mye- loid, endothelial cells, regulatory B cells) could secret IL-35 [19]. Thus, IL-12p35 and EBI3 mRNA ...
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Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms
... H1 receptor antago- nists are lipophilic and therefore may cross the blood– brain ...H1 receptor, due to activation of dopaminergic, serotoninergic, muscarinic and cholinergic receptors, the ...
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Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
... IFNAR1/IFNAR2 receptor. After it binds to the receptor, JAK1 and TYK2 cross-phosphorylate each other and phosphorylate the intracellular domains of the receptors to allow for STAT1 and STAT2 binding through ...
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The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
... p55 receptor and the Fas receptor contain a 60 amino acid domain, known as the ‘death domain’, that is essential for the transduction of apoptotic signals ...Fas receptor and the induction of ...
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Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock
... The current pathogenesis of severe sepsis and septic shock is described as a complex interaction of pro- and anti-inflammation, coagulation, and apoptosis triggered by the infecting microorganism. The bacteria outer ...
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