Interleukin 28B
Meta-analysis of associations of interleukin-28B polymorphisms rs8099917 and rs12979860 with development of hepatitis virus-related hepatocellular carcinoma
... the interleukin-28B (IL28B) gene on chromo- some 19, which codes for IFN- λ 3, are powerful predictors not only of sustained virologic response to combination therapy with Pegylated interferon (PEG-IFN) and ...
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The rs8099917 Polymorphism, When Determined by a Suitable Genotyping Method, Is a Better Predictor for Response to Pegylated Alpha Interferon/Ribavirin Therapy in Japanese Patients than Other Single Nucleotide Polymorphisms Associated with Interleukin 28B
... We focused on determining the most accurate and convenient genotyping methods and most appropriate single nucleotide polymorphism (SNP) among four such polymorphisms associated with interleukin-28B ...
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Interleukin 28B Genotyping by Melt Mismatch Amplification Mutation Assay PCR Analysis Using Single Nucleotide Polymorphisms rs12979860 and rs8099917, a Useful Tool for Prediction of Therapy Response in Hepatitis C Patients
... Several studies have identified associations between single nucleotide polymorphisms (SNPs) occurring near the interleukin-28B (IL-28B) gene and response to antiviral treatment among hepatitis C ...
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Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C
... Recently, three independent groups discovered several strongly correlated single genetic polymorphisms (SNPs) that, together with standard therapy, seem to play a role in clearing the virus [3-5]. These polymorphisms are ...
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The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population
... The allele frequencies and genotype distributions for the two interleukin-28B gene polymorphisms (rs8099917 and rs12979860) among CP patients and control group were shown in Table 2. The genotype ...
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Potential role of interleukin 28B-gene polymorphism and natural immune enhancer treatment response in chronic HCV patients
... the interleukin-28B (IL28B) gene are associated with outcomes from infection with ...of interleukin 28B gene polymorphism (IL28B) and natural immune enhancer treatment response in chronic HCV ...
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Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of Chronic Hepatitis C
... IL28B: interleukin 28B; NR: non-responders; OASL: oligoadenylate synthetases-like; Peg-IFN: Pegylated interferon-alpha; ROC: receiving operating curve; RT-PCR: real time polymerase chain reaction; SNPs: ...
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INTERLEUKIN 28B GENE POLYMORPHISMS AS A PREDICTOR OF TREATMENT RESPONSE IN EGYPTIANS WITH CHRONIC HEPATITIS C.
... Suppiah et al, (2009) 27 reported an association to SVR within the gene region encoding interleukin 28B (rs8099917). IL28B contributes to viral resistance and is known to be upregulated by interferons and ...
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High-Throughput Profiling of Alpha Interferon- and Interleukin-28B-Regulated MicroRNAs and Identification of let-7s with Anti-Hepatitis C Virus Activity by Targeting IGF2BP1
... IFN- ␣ and IL-28B regulate distinct miRNA expression profiles in hepatocytes. To systematically elucidate the changes in host miRNA expression stimulated by type I or type III IFNs, we used high-throughput qRT-PCR ...
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Interleukin 28B gene non TT allele strongly predicts treatment failure for genotype 1 infected chronic hepatitis C patients with advanced fibrosis: a case control study
... IL: Interleukin; HCV: hepatitis C virus; SNP: Single nucleotide polymorphism; peg-IFN: Pegylated interferon; PR: Pegylated interferon plus ribavirin; AF: Advanced fibrosis; SVR: Sustained virologic response; RVR: ...
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ROLE OF SERUM INTERLEUKIN – 10 AND INTERLEUKIN -28B GENE POLYMORPHISMS IN PREDICTING TREATMENT RESPONSE OF HEPATITIS C PATIENTS
... . Interleukin – 10 (IL – 10) is an immunoregulatory cytokine – released by B lymphocytes, macrophages and dendritic cells, and due to its immunoregulatory action, the inadequate levels of IL-10 can determine ...
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Hepatitis C Virus Clearance after Discontinuation of Pegylated Interferon Alpha-2a Monotherapy in a Child
... Copyright © 2012 Takeshi Endo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan
... BRF: Boceprevir; CT: Cytosine and thymine; DAA: Direct-acting antiviral; GT: Guanine and thymine; HCV: Hepatitis C Virus; IFN: Interferon; IL28B: Interleukin 28B; PCR: Polymerase chain r[r] ...
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Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV 1 clinical outcomes and proviral load
... Abstract Background: The Interleukin 28B IL28B rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 HTLV-1 proviral load PvL and th[r] ...
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Distribution of polymorphisms rs12979860, rs8099917 and rs12980275 IL28B in patients with chronic hepatitis C
... is affected by a range of factors, depending on the patient and related to the viral genetic material. Numerous stud- ies indicate that particular genotype of the gene encoding interleukin 28B ...
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Association of MRC-1 and IL-28Bwith the treatment outcome of hepatitis C: a case control study
... infections has been shown to generate superior viro- logical responses than SOC treatment of HCV-1 [4]. Among HCV-2/3 patients, the rates of rapid virological response (RVR) and sustained virological response (SVR) have ...
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Anti inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti inflammatory cyclooxygenase 2 (COX 2) pathway
... Figure 4 MGDG (monogalactosyldiacylglycerol) inhibits NF-kB (Nuclear Factor-kappaB) involved in IL-6 (Interleukin-6) and IL- 8 (Interleukin-8) production. A) Inhibition of IL-6 and IL-8 synthesis by the ...
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Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview
... intracellular events, whereas IL-1β act as an extracellular protein. It has been reported that the levels of IL-1α, IL-1β and also IL-1/IL-receptor antagonist (RA, anti in- flammatory cytokine) have been increased in ...
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A Pilot study to look at the effect of IL-28B polymorphism on IL-28 expression and immunological recovery among HIV-1 infected individuals following Antiretroviral Therapy
... like Interleukin-28 are group of proteins which play an important role in the multiplication of virus and progression of ...controls Interleukin-28 can improve the condition in patients with Hepatitis C ...
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Simvastatin nanoparticles attenuated intestinal ischemia/reperfusion injury by downregulating BMP4/COX-2 pathway in rats
... of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α, and nitric oxide (NO) were checked, and the dry/wet intestine ratios, superoxide dismutase activity, ...
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