Interleukin (IL)-17
Increased interleukin-17 in the cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease: a case-control study of rapidly progressive dementia
... Cytokines are pivotal factors in CNS inflammation in autoimmune and neurodegenerative diseases [4]. The pathogenic activities of cytokines have been vigorously in- vestigated in prion-infected animal models [5-7]. ...
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Parasitemia Induces High Plasma Levels of Interleukin-17 (IL-17) and Low Levels of Interleukin-10 (IL-10) and Transforming Growth Factor- (TGF-) in Pregnant Mice Infected with Malaria
... 0.094. IL-17 production is associated with a very high occurrence of chronic inflammation and immunopathological conditions ...as IL-10 are secreted to reduce the inflammatory response during ...
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Interleukin-23 may contribute to the pathogenesis of lumbar disc herniation through the IL-23/IL-17 pathway
... that interleukin 23 (IL-23) plays an important role in many inflammatory- and autoimmune-related ...about IL-23 in lumbar disc herniation ...whether IL-23 is expressed in intervertebral discs ...
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New insight into the functions of the interleukin 17 receptor adaptor protein Act1 in psoriatic arthritis
... In 2010, a new association between the tumor necrosis factor receptor-associated factor 3-interacting protein 2 (TRAF3IP2) gene and the immune-mediated diseases psoriatic arthritis (PsA) and psoriatic vulgaris (PsV) was ...
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Increasing levels of circulating Th17 cells and interleukin 17 in rheumatoid arthritis patients with an inadequate response to anti TNF α therapy
... The present study is the first attempt to investigate the effects of TNF-a inhibitors on the levels of circulat- ing Th17 cells and Th17-related cytokines in RA patients with a different therapeutic response. In order to ...
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Update on interleukin 17: a role in the pathogenesis of inflammatory arthritis and implication for clinical practice
... that IL-17A and the other cytokines would then inhibit osteoblast differen- tiation and ...of IL-17A, alone and combined with ...and IL-17A are ...and IL-17A are ...
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Interleukin-1 associations in inflammatory bowel disease and the enteropathic seronegative spondylarthritis
... by IL-1b, due to its microbial burden. Libby et al. [17] reported a maximal increase in IL-1 beta mRNA after exposure of human vascular smooth muscle cells to bacterial ...cytokines IL-1b and ...
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The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia
... kits: interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-8, monocyte chemoattractant protein (MCP)-1, IL-17, IL-10 and transforming growth factor (TGF)-β1, and IL-1 ...
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Immunotherapy of brain metastases: breaking a “dogma”
... Indeed, interleukin (IL) -8, macrophage migration in- hibitory factor (MIF), and plasminogen activator inhibitor-1 (PAI-1) released by metastatic lung cancer cells were found to be able to activate ...
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Reduced Frequency of Memory T Cells and Increased Th17 Responses in Patients with Active Tuberculosis
... Successful host defense against M. tuberculosis requires an ef- fective coordination of the innate and adaptive immune re- sponses. The adaptive immune response is characterized by the expansion and differentiation of ...
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<p>HMGB1/CXCL12-Mediated Immunity and Th17 Cells Might Underlie Highly Suspected Autoimmune Epilepsy in Elderly Individuals</p>
... Moreover, interleukin (IL)-4, IL-5, IL-6, IL-17, chemoattractant cytokine ligand (CCL) 17, and CXCL8, which are Th2 and Th17 cell cytokines, are elevated in in fl ammatory ...
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Ethanolic extract of propolis inhibits atherosclerosis in ApoE-knockout mice
... Serum interleukin-6 (IL-6), interleukin-17 (IL-17), endothelin (ET), inducible nitric oxide synthase (iNOS) and vascular endothelial growth factor (VEGF) were determined with ...
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Gut microbiota associated with HIV infection is significantly enriched in bacteria tolerant to oxygen
... of interleukin (IL)-6 and increased tumour necrosis factor (TNF)/ IL-10 ratio have been associated with increased Enterobacteriaceae 15 17 and Eubacterium biforme, 18 respectively, and TCD8+ ...
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Original Article Auxiliary diagnostic value of γδΤ cell, IL-17, and IFN-γ levels in peripheral blood and bronchoalveolar lavage fluid for lung cancer complicated with chronic obstructive pulmonary disease
... cell, interleukin-17 (IL-17), and interferon-γ (IFN-γ) levels in peripheral blood (PB) and bronchoalveolar lavage fluid (BALF) for lung cancer complicated with chronic obstructive pulmonary ...
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Inflammatory and T Helper 17/ Regulatory T Cells Related Cytokines Balance in Cutaneous Lupus Erythematosus (CLE)
... 9,10 Interleukin (IL)-6 is a main pro-inflammatory cytokine, which is necessary for T helper (Th)-17-cell differentiation and prevention of transforming growth factor (TGF)-β-induced regulatory T ...
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Differential expression of pro inflammatory cytokines IL 15Ralpha, IL 15, IL 6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients
... cytokines interleukin 1 (IL1), tumour ne- crosis factor alpha (TNFalpha), and interleukin 6 (IL6), in particular, have been identified and intra-articular as well as systemic levels of these cytokines may ...
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Changes of cytokine levels in a mouse model of post-infectious irritable bowel syndrome
... and interleukin (IL)-1β to promote the inflam- matory response; T-regulatory cells release IL-10 to prevent autoimmunity; in contrast, IL-17, which is pro- duced by Th17 cells, can ...
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Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles
... Results: IPTD-MSCs were expanded in GMP-compatible CMRL-1066 medium supplemented with 5% human platelet lysate (hPL). IPTD-MSCs were found to be highly pure, with > 95% positive for CD90, CD105, and CD73, and negative ...
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Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... active IL-1 molecules: IL-1 ␣ and IL-1  with similar three-dimensional structures (2, 3) that induce similar biological responses via a common plasma membrane receptor, the type I IL-1 ...
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Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview
... Complex diseases, such as inflammatory bowel disease, type 2 diabetes and many other immune-mediated dis- eases, share a number of genetic risk variants. In this re- gard, if a candidate gene has an effect on multiple ...
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