internal ribosomal entry site
The non-primate hepacivirus 5 ' untranslated region possesses internal ribosomal entry site activity
... the internal ribosomal entry site (IRES) of hepatitis C virus (HCV) and GB virus B ...demonstrated internal translation initiation by the NPHV 5 9 UTR in a bicistronic ...
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Heterogeneous Nuclear Ribonucleoprotein L Interacts with the 3′ Border of the Internal Ribosomal Entry Site of Hepatitis C Virus
... by internal entry of a ribosome into the 5 * nontranslated region in a cap-independent ...efficient internal initiation of translation, though the precise border of the HCV internal ...
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Dengue and Zika Virus 5′ Untranslated Regions Harbor Internal Ribosomal Entry Site Functions
... Regardless of whether IRESs are large ( ⬃ 450 nt; poliovirus, encephalomyocarditis virus) or small (e.g., 189 nt; intergenic region IRES in dicistroviruses), they are RNA segments that require the cooperation of cellular ...
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Enterovirus 71 Infection Cleaves a Negative Regulator for Viral Internal Ribosomal Entry Site-Driven Translation
... The translation of EV71 is driven by the internal ribosomal entry site (IRES) on the viral genome (20). Proteins that bind to the IRES and regulate translation by affecting ribosome recruit- ...
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Internal Ribosomal Entry Site-Mediated Translation Initiation in Equine Rhinitis A Virus: Similarities to and Differences from That of Foot-and-Mouth Disease Virus
... II internal ribosomal entry site (IRES) and utilizes two in-frame AUG codons to produce the leader proteinases Lab and ...first site is strongly favored over the ...initiation ...
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A Distinct Class of Internal Ribosomal Entry Site in Members of the Kobuvirus and Proposed Salivirus and Paraturdivirus Genera of the Picornaviridae
... The 5=-untranslated regions (5= UTRs) of picornavirus genomes contain an internal ribosomal entry site (IRES) that promotes the end-independent initiation of translation. Picornavirus IRESs ...
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Revertant analysis of J-K mutations in the encephalomyocarditis virus internal ribosomal entry site detects an altered leader protein.
... dent, internal binding of ribosomes to an RNA segment within the 5 9 untranslated region of the genome (1, 2, 11, ...Most internal ribosomal entry site (IRES) segments span about 400 ...
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Host range phenotype induced by mutations in the internal ribosomal entry site of poliovirus RNA.
... Most poliovirus strains infect only primates. The host range (HR) of poliovirus is thought to be primarily determined by a cell surface molecule that functions as poliovirus receptor (PVR), since it has been shown that ...
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Dual Stem Loops within the Poliovirus Internal Ribosomal Entry Site Control Neurovirulence
... cognate internal ribosomal entry site (IRES) within the 5 * nontranslated region of PV with its counterpart from human rhinovirus type 2 (HRV2) can eliminate the neuropathogenic phenotype in a ...
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An Enzymatic Footprinting Analysis of the Interaction of 40S Ribosomal Subunits with the Internal Ribosomal Entry Site of Hepatitis C Virus
... HCV translation initiation occurs on an internal ribosomal entry site (IRES) rather than by the 5⬘ cap-mediated mecha- nism that is used by most eukaryotic mRNAs (40, 42). IRESs also occur in ...
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A New Internal Ribosomal Entry Site 5′ Boundary Is Required for Poliovirus Translation Initiation in a Mouse System
... Four mutants of the virulent Mahoney strain of poliovirus were generated by introducing mutations in nucleotides (nt) 128 to 134 of the genome, a region that contains a part of the stem-loop II (SLII) structure located ...
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Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions.
... The proposed bent helix binding site for p57 is consistent with p57 cross-linking to other fragments of the EMCV IRES 4, 22, foot-and-mouth disease virus IRES 27, and stem-loop VI of the[r] ...
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The 3′-Untranslated Region of Hepatitis C Virus RNA Enhances Translation from an Internal Ribosomal Entry Site
... PTB-binding site (18), we included both the 59-UTR and the entire core protein-encoding region (1 to 914 nt from the 59 end of the viral RNA) as part of the 59-end sequence in all of these ...PTB-binding ...
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Genetic Analysis of a Poliovirus/Hepatitis C Virus Chimera: New Structure for Domain II of the Internal Ribosomal Entry Site of Hepatitis C Virus
... Internal ribosomal entry sites (IRESs) of certain plus-strand RNA viruses direct cap-independent initiation of protein synthesis both in vitro and in vivo, as can be shown with artificial dicistronic ...
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In vitro characterization of an internal ribosomal entry site (IRES) present within the 5' nontranslated region of hepatitis A virus RNA: comparison with the IRES of encephalomyocarditis virus.
... Although AUG-12 is the preferred initiation codon when the full-length 5'NTR is present, either Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest DISCUSSION Earlier work, [r] ...
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Use of a mammalian internal ribosomal entry site element for expression of a foreign protein by a transfectant influenza virus.
... and 5' NA N.C., 3' and 5' noncoding regions of the influenza A/WSN/33 virus NA gene 10; delNA, small ORF 110 aa derived from the influenza A/WSN/33 virus NA coding sequences; BIP, IRES s[r] ...
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Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation.
... Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.. Initiati[r] ...
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Genetically Stable Picornavirus Expression Vectors with Recombinant Internal Ribosomal Entry Sites
... ternal ribosomal entry (15, 16, 22, 23). The internal ribosomal entry site (IRES), a complex cis-acting genetic element with extensive secondary structure, mediates ...
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First Evidence for Internal Ribosomal Entry Sites in Diverse Fungal Virus Genomes
... well-established internal ribosomal entry site (IRES)-mediated translational initiation in animals and plants, no IRESs were established in fungal vi- ral or cellular ...an internal ...
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Mutational Analysis of the Bovine Hepacivirus Internal Ribosome Entry Site
... an internal ribosome entry site (IRES) enabling 5= cap-independent translation of viral proteins ...the ribosomal subunit 40S can directly bind the IRES through a high-affinity interaction ...
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