Interstitial collagenase
Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast derived cathepsin B
... including interstitial collagenase, 92-kD gelatinase, and ...this collagenase-generated fragment can be readily degraded to completion by cathepsin B at 37 degrees C and pH ...32-kD ...
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Interstitial collagenase (matrix metalloproteinase 1) expresses serpinase activity
... human interstitial collagenase (matrix metalloproteinase-1), an enzyme whose only known physiologic substrate has heretofore been believed to be the extracellular matrix molecule, ...
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Role of the angiotensin converting enzyme 1/angiotensin II/angiotensin receptor 1 axis in interstitial collagenase expression in human carotid atheroma
... The underlying regulatory mechanism behind the benefits of blockade of the pressor axis in atherosclerosis has not been fully investigated. In this study we aimed to clarify the roles of ACE1, AII and ATR1 in modifying ...
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Immune modulation of metalloproteinase production in human macrophages Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon gamma
... Interferon-gamma (IFN-gamma) is a lymphokine that activates mononuclear phagocytes. To test the hypothesis that IFN-gamma might have important effects upon the ability of human mononuclear phagocytes to degrade ...
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Cell matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing
... wounds, collagenase mRNA, localized by in situ hybridization, was prominently expressed by basal keratinocytes bordering the sites of active re-epithelialization indicating that collagenolytic activity is a ...
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Human osteoblasts in vitro secrete tissue inhibitor of metalloproteinases and gelatinase but not interstitial collagenase as major cellular products
... collagenase, tissue inhibitor of metalloproteinases (TIMP), and gelatinolytic enzymes. Cells were isolated by bacterial collagenase digestion of trabecular bone (vertebra, rib, tibia, and femur) from 11 ...
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Neutral metalloproteinases produced by human mononuclear phagocytes Enzyme profile, regulation, and expression during cellular development
... IV collagenase was released by peripheral blood monocytes and uninduced U937 monocyte-like cells, whereas stromelysin was secreted only by lipopolysaccharide-stimulated alveolar ...of interstitial ...
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Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
... (interstitial collagenase, MMP-1; gelatinases, MMP-2 and MMP-9; and stromelysin, MMP-3) and their endogenous inhibitors (TIMPs 1 and 2) by immunocytochemistry, zymography, and ...
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Ochratoxin A-Induced Renal Cortex Fibrosis and Epithelial-to-Mesenchymal Transition: Molecular Mechanisms of Ochratoxin A-Injury and Potential Effects of Red Wine
... similar interstitial collagenase expression, suggests that MMP-1 inhibition may be one of the molecular mechanisms underlying COL accumulation in OTA and OTA-wine treated rats, leading to the histological ...
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Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss
... of interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), gelatinase B (MMP-9), TIMP-1 and TIMP-2 in aliquots of serum stored from women with a history of RPL and age- matched pregnant controls without a ...
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Idiopathic Interstitial Pneumonias (IIPs): Review of Clinical, Radiographic and High Resolution Computed Tomography (HRCT)
... desquamative interstitial pneumonia. DIP is considered as a form of interstitial pneumonia in which the alveolar spaces shows the presence of diffuse exudation of pigmented macrophages ...of ...
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Interstitial lung disease
... Familial interstitial pneumonia remains classified as an IIP despite the genetic ...usual interstitial pneumonia (UIP) or different patterns of smoking-related IIPs), MDD may determine the clinical ...
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Localization of collagenase in the growth plate of rachitic rats
... rickets. Collagenase was quantitated by a pellet assay based on the release of solubilized collagen from the endogenous insoluble collagen in the tissue ...rickets, collagenase activity and hypertrophic ...
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Expression of HSP47 in Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia
... usual interstitial pneumonia (UIP) associ- ated with a collagen vascular disease (CVD) have an improved prognosis compared with patients with idio- pathic UIP ...of interstitial pneumonia [17-19], there are ...
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Usual interstitial pneumonia coexisted with nonspecific interstitial pneumonia, What’s the diagnosis?
... nonspecific interstitial pneumonia(INSIP) and idiopathic pulmonary fibrosis (IPF) / usual interstitial pneumonia (UIP), accurate diagnosis for this two dis- eases become critical for clinicians and ...
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Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development
... Single-cell dissociation of human fetal kidney. One human embryo of w16 (male) was isolated and the kidney dissected in cold saline solution (0.9% NaCl, Versylene Fresenius, Almere, Netherlands). For sex genotyping, ...
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Clinical and morphological effects of hyperbaric oxygen therapy in patients with interstitial cystitis associated with fibromyalgia
... Background: Interstitial Cystitis (IC) is a debilitating disorder of the bladder, with a multifactorial and poorly understood origin dealing with microcirculation repeated ...
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Retrospective analysis of renal histology in asymptomatic patients with probable chronic kidney disease of unknown aetiology in Sri Lanka
... of interstitial fibrosis involving less than 10% mild fibrosis, multifocal fibrosis involving 10-50% moderate fibrosis and diffuse or coarse scarring involving more than 50% of the cortex severe ...
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Basal interstitial water pressure in laboratory debris flows over a rigid bed in an open channel
... the interstitial fluid can be regarded as pure ...the interstitial water pressure under the minimum condition is ...The interstitial water pressure in debris flows with that condition will be the ...
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Spectrum of HRCT findings in interstitial lung diseases and their correlation with mediastinal lymphadenopathy
... of interstitial thickening as well as airspace filling and is a non-specific finding and considered to be an important sign, which indicates the presence of active and potentially treatable ...
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