intestinal homeostasis
CD98 expression modulates intestinal homeostasis, inflammation, and colitis associated cancer in mice
... in intestinal inflam- matory conditions, such as inflammatory bowel disease (IBD), and in various carcinomas, yet its pathogenetic role remains ...in intestinal epithelial cells (IECs), we explored the role ...
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The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer
... reduced intestinal proliferation and impaired differentiation of secretory lineage ...fewer intestinal tumors, and importantly, in established tumors, Usp28 deletion reduced tumor size and dramatically ...
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Role of Ldb1 in Adult Intestinal Homeostasis
... of intestinal crypts is drastically ...in intestinal crypts and/or in neighboring mesenchymal cells also triggers activation of Wnt signaling in the stem cell niches of the small ...tissue ...
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RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis
... Deregulation of the Wnt/APC/β-catenin signaling pathway is an important consequence of tumor suppressor APC dysfunction. Genetic and molecular data have established that disruption of this pathway contributes to the ...
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Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila
... of intestinal stem ...control intestinal homeostasis in Drosophila, and provide physiological evidence for the idea that the function of Tnks and Iduna is tightly ...
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Dendritic cells in intestinal homeostasis and disease
... The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal ...to intestinal disease ...
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Monoassociation with Lactobacillus plantarum Disrupts Intestinal Homeostasis in Adult Drosophila melanogaster
... basal intestinal stem cells (ISCs) divide and differentiate at a rate that maintains an intact epithelial barrier (17, 20, ...by intestinal microbes that activate local immune responses and drive the ...
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p120 catenin is essential for maintenance of barrier function and intestinal homeostasis in mice
... The severity of the phenotype is exacerbated by a significant inflammatory response, reminiscent of the major intestinal bowel diseases in humans. Previously, Jeffrey Gordon and colleagues showed that transgenic ...
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Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis
... immunostaining, intestinal crypt cultures were fixed in 4% PFA for 10 minutes at room temperature, samples were transferred to a 30% sucrose solu- tion for 24 hours at 4°C, embedded, and flash frozen in ...
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Maintenance of intestinal homeostasis by mucosal barriers
... IEC: Intestinal epithelial cell; IFN: Interferon; IgA: Immunoglobulin A; IL: Interleukin; ILC: Innate lymphoid cell; Lypd8: Ly6/Plaur domain containing 8; MDR: Multi-drug resistance protein; MMP-7: Matrix ...
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The role of TGFß-Activated Kinase 1 Signaling in Reactive Oxygen Species and Intestinal Homeostasis.
... the intestinal epithelium, Paneth cells, was depleted in the Tak1-deficient small intestine (shown in the current ...specialized intestinal epithelial cells, which have a very long life span of around 6-8 ...
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Intestinal development and homeostasis require activation and apoptosis of diet reactive T cells
... The impact of food antigens on intestinal homeostasis and immune function is poorly understood. Here, we explored the impact of dietary antigens on the phenotype and fate of intestinal T cells. ...
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The ADP ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila
... studying intestinal homeostasis, regeneration and tumorigenesis (Jiang and Edgar, ...During homeostasis, Wingless signaling regulates ISC proliferation (Buchon et ...
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Fumonisins affect the intestinal microbial homeostasis in broiler chickens, predisposing to necrotic enteritis
... the intestinal microbiota of the ...small intestinal length, ileal villus height, and crypt depth were negatively af- fected by ...on intestinal microbiota shows remarkable simi- ...the ...
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Imaging Chloride Homeostasis in Neurons
... some difficulties due to the sample thickness: to compute the chloride concentration with the available sensors it is necessary to measure the fluorescence emitted and/or excited at different wavelengths and to compare ...
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homeostasis and endocrine signaling
... Figure 32.11c TSH circulation throughout body Anterior pituitary Thyroid gland Stimulus Response Thyroid hormone Thyroid hormone circulation throughout body TSH − TRH Neurosecretory cell[r] ...
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Intestinal amoebiasis, giardiasis and geohelminthiases: their association with other intestinal parasites and reported intestinal symptoms
... Complete questionnaire results, intestinal helminth infections derived from 4 Kato-Katz thick smears, and intestinal protozoa infections assessed on a single day by a [r] ...
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Th17/Treg homeostasis, but not Th1/Th2 homeostasis, is implicated in exacerbation of human bronchial asthma
... Treg homeostasis could be adopted to predict asthma pro- gression, such as asthma exacerbation, we compared the levels of cytokines and transcript factor mRNA specifically related to Th17 and Tregs, with the ...
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WSB1: from homeostasis to hypoxia
... Thyroid homeostasis: WSB1 participated in an E3 complex to ubiquitinylate the metabolic regulatory protein, thyroid hormone-activating type 2 iodothyr- onine deiodinase(D2) ...
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CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice
... The two most common forms of inflammatory bowel disease (IBD), Crohn’s disease and ulcerative colitis, affect approximately 1 million people in the United States. Uncontrolled APC reactivity toward commensal bacteria is ...
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