intestinal stem cells
Wnt signaling suppresses MAPK driven proliferation of intestinal stem cells
... days. Intestinal stem cells (ISCs) in the base of intestinal crypts tightly control this process by producing intestinal progenitors known as transit amplifying (TA) cells, which ...
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Plasticity of Paneth cells and their ability to regulate intestinal stem cells
... Paneth cells affect intestinal stem cells in ageing Ageing is an inevitable biological event and is usually ac- companied by decreased function, including diminished self-renewal ability of ...
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EGF signaling regulates the proliferation of intestinal stem cells in Drosophila
... somatic stem cell proliferation is crucial to ensure maintenance of tissue homeostasis in high-turnover ..., intestinal stem cells (ISCs) are essential for homeostatic turnover of the ...
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Regulation and plasticity of intestinal stem cells during homeostasis and regeneration
... crypt cells, as well as crypt fission – the process by which one crypt produces two crypts – to repopulate the epithelium (Withers and Elkind, ...by stem cells, and multiple strategies can be ...
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Age-related dysfunction of the DNA damage response in intestinal stem cells
... tissue-resident stem/progenitor cells (TSCs, also known as somatic stem cells) are associated with perturbation of tissue homeostasis ...of stem cell functions has attracted much ...
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Heterogeneity of the Level of Activity of Lgr5+ Intestinal Stem Cells
... experimentation. Intestinal crypt homeostasis and intestinal tumorigenesis have been the topic of several mathematical ...of stem cells exist in the intestinal crypt with distinct ...
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Migration of Drosophila intestinal stem cells across organ boundaries
... 8-12 cells each scattered throughout the ...peripheral cells of the AMP clusters, was sandwiched in between the adult and larval midgut (Takashima et ...engulfing cells of the proximal segment of the ...
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Circulating hematopoietic stem cells and putative intestinal stem cells in coeliac disease
... Indeed, it has been demonstrated that in active CD the status of chronic inflammation worsens the epithelial layer damage, thus causing activation of NF- κ B, which leads to a vicious cycle of aberrant immune response, ...
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Epigenetic Regulation of Embryonic and Intestinal Stem Cells by DNA Hydroxymethylation
... DNA methylation is a widespread epigenetic modification that regulates gene expression in development and cellular differentiation (Reik et al., 2001; Sheaffer et al., 2014; Smith and Meissner, 2013). DNA methylation is ...
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2019_Iyengar.pdf
... primary intestinal epithelial cells was a challenge due to cells’ lack of proliferation when they were placed in ...these cells were able to effectively proliferate as confluent ...healthy ...
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The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis
... in intestinal stem cells and demonstrate that its downregulation in colorectal carcinoma cells impedes ...melanoma cells inhibits lung metastasis ...
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The balance of power: innate lymphoid cells in tissue inflammation and repair
... mal cells to facilitate muscle regeneration ...on intestinal stem cells to promote β-catenin pathway–dependent renewal ...in intestinal repair, linking mucosal ILCs with a central EGF ...
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Epithelial stem cell culture: modeling human disease and applications for regenerative medicine
... Although intestinal stem cells possess the remarkable capacity to proliferate at a high turnover rate to main- tain intestinal epithelia, and hepatocytes are highly regenerative in response to ...
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Derivation of adult canine intestinal organoids for translational research in gastroenterology
... of intestinal stem cells, epithelial differentiation, and maturation, and then the respective mRNA was serially amplified ...dot/10 cells is no staining; 1–3 dots/cell is +; 4–9 dots/cell is ...
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JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates
... of intestinal stem cells (ISCs) that give rise to all cell types within the midgut ...several intestinal cell ...gut cells, leading to the formation of tumors composed of progenitor ...
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Crosstalk between H9N2 avian influenza virus and crypt-derived intestinal organoids
... human intestinal epithelial cell line, HT-29 ...the intestinal tract can result in severe destruction of the mucosa, which was characterized by the loss of epithelial cells and crypt distortion by ...
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When stem cells grow old: phenotypes and mechanisms of stem cell aging
... resident stem cells. Adult stem cells are characterized by the ability to self-renew and differentiate into multiple cell types within a ...that stem cells are nonetheless ...
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Tissue engineering laboratory models of the small intestine
... with intestinal stem cells, organoid units or human colonic adenocarcinoma cell lines.. such as Caco-2 and HT29-MTX to generate a number of in vitro and in vivo models.[r] ...
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Inhibition of CDK4/6 protects against radiation induced intestinal injury in mice
... Small intestinal epithelium is the fastest-renewing adult tissue, with a turnover rate of 3 to 5 days in mice that is fueled by intestinal stem cells (ISCs) (1, ...columnar cells (CBCs) ...
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Gut instincts: thoughts on intestinal epithelial stem cells
... maturation. Intestinal stem cells reside at the origin of the migration, which is found just above the crypt base in the small intestine and at the crypt base in the colon ...the stem ...
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