intrinsic pathway
Intrinsic Pathway−Mediated Apoptosis in Elastase Induced Aneurysms in Rabbits
... and/or intrinsic pathway, both leading to a final common pathway in which activated downstream caspases are involved in DNA ...extrinsic pathway, known as the death- receptor pathway, ...
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Simian Varicella Virus Induces Apoptosis in Monkey Kidney Cells by the Intrinsic Pathway and Involves Downregulation of Bcl-2 Expression
... proteins (20). Our findings show that SVV-induced apoptosis involves downregulation of Bcl-2 expression, which probably led to release of cytochrome c (Fig. 7) followed by activation of caspase-9 (Fig. 4). ...
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The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells
... activation and loss of mitochondrial membrane potential followed by ROS production, which are all events associated with the mitochondrial apoptotic pathway. Moreover, Jurkat cells deficient for caspase-9, the ...
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Original Article Human cytomegalovirus impairs megakaryopoiesis by reducing c-Mpl expression and inducing apoptosis via the intrinsic pathway
... Abstract: Background: Human cytomegalovirus (HCMV) is a frequent life-threatening infection of immunocompro- mised individuals. A commonly observed clinical manifestation of active HCMV infection in these patients is ...
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Synergistic Effects of Arsenic Trioxide and Radiation: Triggering the Intrinsic Pathway of Apoptosis
... signature of Bax/Bcl-2, ATO may activate intrinsic pathway of apoptosis, though caspase-3 is the milestone of both intrinsic and extrinsic pathways. Dizaji et al. [41] have reported that ATO and ...
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Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo
... Results: Cordycepin inhibited cell viability, proliferation and colony formation ability and induced cell cycle arrest and early apoptosis of human pancreatic cancer cells (MIAPaCa-2 and Capan-1) in a dose- and ...
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Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway
... In this study, the protein levels of caspase-3/7 were increased in breast cancer cell lines, after exposure to BTB extract. This is one mechanism by which BTB extract may contribute to the inhibition of breast car- ...
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<p>The total flavonoid of <em>Eucommia ulmoides</em> sensitizes human glioblastoma cells to radiotherapy via HIF-α/MMP-2 pathway and activates intrinsic apoptosis pathway</p>
... Radiotherapy was among the major strategies against can- cers. In order to explore the application value of the total fl avonoid of Eucommia ulmoides, we performed the clono- genic assays with irradiation to analyze the ...
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Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell line
... Background: 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16) is a unique, in silico-designed compound with possible anticancer properties, which were identified in our laboratory. This compound is capable of ...
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Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway
... receptor pathway [32,33]. In the intrinsic pathway, many factors such as environmental changes, stimuli and drugs could induce mitochondria ...via intrinsic mitochon- dria pathway ...
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PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway
... Abstract: Chemotherapy offers a systemic cancer treatment; however, it is limited in clinical administration due to its serious side effects. In cancer medicine, the use of nanoparticles (NPs) drug delivery system (DDS) ...
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Genomics and the intrinsic value of plants
... approaches thought to be specific for genomics. Genomics could, or is expected to, generate knowledge of plants that would allow obtaining desired improvements without the need for genetic engineering. In that case ...
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On Intrinsic Rotation of Bodies
... generate intrinsic torque, it motivates spontaneous rotation at all levels of the cosmic mass scale from the electron to the un- iverse; its atomic and natural units are ( ) ...
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Intrinsic and Extrinsic Motivation.pdf
... Extrinsic motivation is a construct that pertains whenever an activity is done in order to attain some separable outcome. Extrinsic motivation thus contrasts with intrinsic motivation, which refers to doing an ...
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Radioiodination of human intrinsic factor
... Human intrinsic factor (IF) saturated with 60 Co-labeled cyanocobalamin ( 60 CoB 12 ) was purified and then iodinated with 125 I to yield 125 I-labeled IF- 60 CoB 12 preparations of high specific ...
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A Note on Intrinsic Correlation
... We have characterized the set of strategies played under a s.e.i.c. and showed by an iterative procedure that it is always non-empty. Some interesting questions for the future include the relationship and inter- action ...
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Intrinsic Gradient Networks
... an intrinsic gradient network corresponds to a single neuron, which communicates via its firing ...an intrinsic gradient network could also correspond to small populations of neurons such as cortical ...
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Intrinsic Prices of Risk
... exist intrinsic risks inherent in every contingent ...all intrinsic risks; that is the set of all real valued functions on Ω ...an intrinsic risk π π = ( ) ω on the scenario ω ∈ Ω ...of ...
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Studies on Antibody to Intrinsic Factor
... Sera from a group of 79 patients with pernicious anemia were studied for the presence of antibody to intrinsic factor. Two general types of antibody activity were found, and it was possible to distinguish three ...
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The intrinsic quantum Hall effect
... Self-consistent calculations are made of the electrostatic Hall potential EHP, the local chemical potential LCP, and current density in a uniform ballistic quantum wire containing two-di[r] ...
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